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The effect of diet on the Vervet monkey endocrine pancreas.
J Med Primatol. 1997 Dec; 26(6):307-11.JM

Abstract

Vervet monkeys (Cercopithecus aethiops) used for pancreatic endocrine cell distribution studies were found to have been maintained on different diets. Although the effect of dietary changes on the exocrine pancreas has been described in several animals, little, apart from the effect of malnutrition, has been reported for the endocrine pancreas. Reported here are pancreatic endocrine cell distributions in monkeys on a standard diet (n = 3) compared with monkeys on an atherogenic diet (n = 3). Quantitation of immunolabelled pancreatic endocrine cell types revealed a significant 80% increase in A (glucagon) cell volume in monkeys on an atherogenic diet concomitant with a significant reduction in B (insulin) cell volume to approximately 60% of normal. This reflects a pattern of events that occurs in non-insulin dependent diabetes. An accompanying reduction in PP (pancreatic polypeptide) cell volumes supports our hypothesis that altering A and PP cell volumes could reflect differential gene expression in those cells in the adult in which glucagon and PP are co-localized.

Authors+Show Affiliations

Experimental Biology Programme, MRC, Tygerberg, South Africa.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9438224

Citation

Louw, J, et al. "The Effect of Diet On the Vervet Monkey Endocrine Pancreas." Journal of Medical Primatology, vol. 26, no. 6, 1997, pp. 307-11.
Louw J, Woodroof C, Seier J, et al. The effect of diet on the Vervet monkey endocrine pancreas. J Med Primatol. 1997;26(6):307-11.
Louw, J., Woodroof, C., Seier, J., & Wolfe-Coote, S. A. (1997). The effect of diet on the Vervet monkey endocrine pancreas. Journal of Medical Primatology, 26(6), 307-11.
Louw J, et al. The Effect of Diet On the Vervet Monkey Endocrine Pancreas. J Med Primatol. 1997;26(6):307-11. PubMed PMID: 9438224.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of diet on the Vervet monkey endocrine pancreas. AU - Louw,J, AU - Woodroof,C, AU - Seier,J, AU - Wolfe-Coote,S A, PY - 1998/1/23/pubmed PY - 1998/1/23/medline PY - 1998/1/23/entrez SP - 307 EP - 11 JF - Journal of medical primatology JO - J Med Primatol VL - 26 IS - 6 N2 - Vervet monkeys (Cercopithecus aethiops) used for pancreatic endocrine cell distribution studies were found to have been maintained on different diets. Although the effect of dietary changes on the exocrine pancreas has been described in several animals, little, apart from the effect of malnutrition, has been reported for the endocrine pancreas. Reported here are pancreatic endocrine cell distributions in monkeys on a standard diet (n = 3) compared with monkeys on an atherogenic diet (n = 3). Quantitation of immunolabelled pancreatic endocrine cell types revealed a significant 80% increase in A (glucagon) cell volume in monkeys on an atherogenic diet concomitant with a significant reduction in B (insulin) cell volume to approximately 60% of normal. This reflects a pattern of events that occurs in non-insulin dependent diabetes. An accompanying reduction in PP (pancreatic polypeptide) cell volumes supports our hypothesis that altering A and PP cell volumes could reflect differential gene expression in those cells in the adult in which glucagon and PP are co-localized. SN - 0047-2565 UR - https://www.unboundmedicine.com/medline/citation/9438224/The_effect_of_diet_on_the_Vervet_monkey_endocrine_pancreas_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0047-2565&date=1997&volume=26&issue=6&spage=307 DB - PRIME DP - Unbound Medicine ER -