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Clinical studies in alcoholic sideroblastosis.
Arch Intern Med. 1976 Mar; 136(3):283-9.AI

Abstract

The incidence and characteristics of ring sideroblastic and megaloblastic changes in bone marrow were studied in chronically ill, malnourished alcoholics and well-nourished alcoholics without complicating medical illness. A clear correlation of blood alcohol level with changes in serum pyridoxal-5-phosphate (PLP) values or with the incidence of ring sideroblasts could not be demonstrated. The appearance of ring sideroblasts was associated with dietary restrictions of pyridoxine and noticeable folic-acid-deficient megaloblastosis. The majority of subjects with ring sideroblasts were from the chronic, malnourished alcoholic group; the number of sideroblasts correlated with severity of marrow magaloblastic change. While low serum PLP levels were characteristic of the chronically ill alcoholic with ring sideroblasts, equally low levels were detected in the absence of the marrow abnormality. Thus, a low serum PLP value alone is not a certain indication of the presence of marrow ring sideroblasts.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

944024

Citation

Pierce, H I., et al. "Clinical Studies in Alcoholic Sideroblastosis." Archives of Internal Medicine, vol. 136, no. 3, 1976, pp. 283-9.
Pierce HI, McGuffin RG, Hillman RS. Clinical studies in alcoholic sideroblastosis. Arch Intern Med. 1976;136(3):283-9.
Pierce, H. I., McGuffin, R. G., & Hillman, R. S. (1976). Clinical studies in alcoholic sideroblastosis. Archives of Internal Medicine, 136(3), 283-9.
Pierce HI, McGuffin RG, Hillman RS. Clinical Studies in Alcoholic Sideroblastosis. Arch Intern Med. 1976;136(3):283-9. PubMed PMID: 944024.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical studies in alcoholic sideroblastosis. AU - Pierce,H I, AU - McGuffin,R G, AU - Hillman,R S, PY - 1976/3/1/pubmed PY - 1976/3/1/medline PY - 1976/3/1/entrez SP - 283 EP - 9 JF - Archives of internal medicine JO - Arch Intern Med VL - 136 IS - 3 N2 - The incidence and characteristics of ring sideroblastic and megaloblastic changes in bone marrow were studied in chronically ill, malnourished alcoholics and well-nourished alcoholics without complicating medical illness. A clear correlation of blood alcohol level with changes in serum pyridoxal-5-phosphate (PLP) values or with the incidence of ring sideroblasts could not be demonstrated. The appearance of ring sideroblasts was associated with dietary restrictions of pyridoxine and noticeable folic-acid-deficient megaloblastosis. The majority of subjects with ring sideroblasts were from the chronic, malnourished alcoholic group; the number of sideroblasts correlated with severity of marrow magaloblastic change. While low serum PLP levels were characteristic of the chronically ill alcoholic with ring sideroblasts, equally low levels were detected in the absence of the marrow abnormality. Thus, a low serum PLP value alone is not a certain indication of the presence of marrow ring sideroblasts. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/944024/Clinical_studies_in_alcoholic_sideroblastosis_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/vol/136/pg/283 DB - PRIME DP - Unbound Medicine ER -