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Gastrins in tissue. Concentration and component pattern in gastric, duodenal, and jejunal mucosa of normal human subjects and patients with duodenal ulcer.
Gastroenterology. 1976 May; 70(5 PT.1):697-703.G

Abstract

The total concentration of gastrin and distribution of gastrin components were examined in mucosal biopsies from corpus, antrum, duodenum, and jejunum from normal subjects and patients with duodenal ulcer. The concentration was highest in the antrum, being 12.1+/-1.9 nmol per g of mucosa (mean +/-SEM) for normal subjects, and 9.0 +/-1.6 nmol per g of mucosa for duodenal ulcer patients (P eaual to 0.03). A steep gradient was found distally: in the proximal duodenum the concentration was 0.1; in the distal duodenum, 0.02 to 0.01; and in the proximal jejunum, less than 0.01 of the antral concentration. In corpus of the stomach, the concentrations were similar to those found in the jejunum. Gel filtrations showed that most gastrin immunoreactivity was eluted in positions corresponding to serum component II (gastrin-34-like) and III (gastrin-17-like), but immunoreactivity corresponding to all the components present in serum was found. No interference from cholecystokinin was observed in duodenal biopsies. In corpus, antrum, and jejunum component III was the predominant form, whereas component II made up half of immunoreactive gastrin in the duodenum. No major differences were observed between normal subjects and duodenal ulcer patients. There was no simple relationship between acid secretion and mucosal gastrin concentration, but ulcer patients with the highest acid secretion had the lowest antral content and the highest duodenal content.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

944152

Citation

Malstrom, J, et al. "Gastrins in Tissue. Concentration and Component Pattern in Gastric, Duodenal, and Jejunal Mucosa of Normal Human Subjects and Patients With Duodenal Ulcer." Gastroenterology, vol. 70, no. 5 PT.1, 1976, pp. 697-703.
Malstrom J, Stadil F, Rehfeld JF. Gastrins in tissue. Concentration and component pattern in gastric, duodenal, and jejunal mucosa of normal human subjects and patients with duodenal ulcer. Gastroenterology. 1976;70(5 PT.1):697-703.
Malstrom, J., Stadil, F., & Rehfeld, J. F. (1976). Gastrins in tissue. Concentration and component pattern in gastric, duodenal, and jejunal mucosa of normal human subjects and patients with duodenal ulcer. Gastroenterology, 70(5 PT.1), 697-703.
Malstrom J, Stadil F, Rehfeld JF. Gastrins in Tissue. Concentration and Component Pattern in Gastric, Duodenal, and Jejunal Mucosa of Normal Human Subjects and Patients With Duodenal Ulcer. Gastroenterology. 1976;70(5 PT.1):697-703. PubMed PMID: 944152.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastrins in tissue. Concentration and component pattern in gastric, duodenal, and jejunal mucosa of normal human subjects and patients with duodenal ulcer. AU - Malstrom,J, AU - Stadil,F, AU - Rehfeld,J F, PY - 1976/5/1/pubmed PY - 1976/5/1/medline PY - 1976/5/1/entrez SP - 697 EP - 703 JF - Gastroenterology JO - Gastroenterology VL - 70 IS - 5 PT.1 N2 - The total concentration of gastrin and distribution of gastrin components were examined in mucosal biopsies from corpus, antrum, duodenum, and jejunum from normal subjects and patients with duodenal ulcer. The concentration was highest in the antrum, being 12.1+/-1.9 nmol per g of mucosa (mean +/-SEM) for normal subjects, and 9.0 +/-1.6 nmol per g of mucosa for duodenal ulcer patients (P eaual to 0.03). A steep gradient was found distally: in the proximal duodenum the concentration was 0.1; in the distal duodenum, 0.02 to 0.01; and in the proximal jejunum, less than 0.01 of the antral concentration. In corpus of the stomach, the concentrations were similar to those found in the jejunum. Gel filtrations showed that most gastrin immunoreactivity was eluted in positions corresponding to serum component II (gastrin-34-like) and III (gastrin-17-like), but immunoreactivity corresponding to all the components present in serum was found. No interference from cholecystokinin was observed in duodenal biopsies. In corpus, antrum, and jejunum component III was the predominant form, whereas component II made up half of immunoreactive gastrin in the duodenum. No major differences were observed between normal subjects and duodenal ulcer patients. There was no simple relationship between acid secretion and mucosal gastrin concentration, but ulcer patients with the highest acid secretion had the lowest antral content and the highest duodenal content. SN - 0016-5085 UR - https://www.unboundmedicine.com/medline/citation/944152/Gastrins_in_tissue__Concentration_and_component_pattern_in_gastric_duodenal_and_jejunal_mucosa_of_normal_human_subjects_and_patients_with_duodenal_ulcer_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S001650857600125X DB - PRIME DP - Unbound Medicine ER -