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Serum ionized magnesium: relation to blood pressure and racial factors.
Am J Hypertens 1997; 10(12 Pt 1):1420-4AJ

Abstract

To study potential ionic factors predisposing to vascular disease in hypertension, particularly among black subjects, we used a recently developed combined magnesium and calcium specific, ion selective electrode apparatus to measure extracellular ionized calcium (Ca-ion), ionized magnesium (Mg-ion), and Ca-ion/Mg-ion ratios in the serum of fasting, nonmedicated white and black normotensive (n = 61) and hypertensive (n = 23) subjects, studied consecutively in a tertiary referral center. Both race and blood pressure status had independent effects on the distribution of Mg-ion values. Although Mg-ion levels for the group as a whole were lower in hypertensive versus in normotensive subjects (0.571+/-0.012 v 0.601+/-0.005 mmol/L; P < .01), this was only true of white subjects (0.579+/-0.021 v 0.620+/-0.006 mmol/L; P = .0095). The lack of a significant difference in Mg-ion levels between black hypertensive versus normotensive subjects (0.553+/-0.012 v 0.577+/-0.007 mmol/L, P = NS) was attributable to the significantly lower Mg-ion levels present in normotensive blacks compared to those in normotensive white subjects (0.577+/-0.007 v 0.620+/-0.006 mmol/L, P = .0001). Resultant Ca-ion/Mg-ion ratios were elevated in all black subjects and in white hypertensive subjects. These data support the presence among hypertensives and among black subjects (independently of blood pressure) of a consistent depletion of circulating magnesium and of an imbalance of calcium and magnesium that may potentiate vascular disease among these subjects.

Authors+Show Affiliations

Cardiovascular Center, New York Hospital-Cornell Medical Center, New York, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9443780

Citation

Resnick, L M., et al. "Serum Ionized Magnesium: Relation to Blood Pressure and Racial Factors." American Journal of Hypertension, vol. 10, no. 12 Pt 1, 1997, pp. 1420-4.
Resnick LM, Bardicef O, Altura BT, et al. Serum ionized magnesium: relation to blood pressure and racial factors. Am J Hypertens. 1997;10(12 Pt 1):1420-4.
Resnick, L. M., Bardicef, O., Altura, B. T., Alderman, M. H., & Altura, B. M. (1997). Serum ionized magnesium: relation to blood pressure and racial factors. American Journal of Hypertension, 10(12 Pt 1), pp. 1420-4.
Resnick LM, et al. Serum Ionized Magnesium: Relation to Blood Pressure and Racial Factors. Am J Hypertens. 1997;10(12 Pt 1):1420-4. PubMed PMID: 9443780.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum ionized magnesium: relation to blood pressure and racial factors. AU - Resnick,L M, AU - Bardicef,O, AU - Altura,B T, AU - Alderman,M H, AU - Altura,B M, PY - 1998/1/27/pubmed PY - 1998/1/27/medline PY - 1998/1/27/entrez SP - 1420 EP - 4 JF - American journal of hypertension JO - Am. J. Hypertens. VL - 10 IS - 12 Pt 1 N2 - To study potential ionic factors predisposing to vascular disease in hypertension, particularly among black subjects, we used a recently developed combined magnesium and calcium specific, ion selective electrode apparatus to measure extracellular ionized calcium (Ca-ion), ionized magnesium (Mg-ion), and Ca-ion/Mg-ion ratios in the serum of fasting, nonmedicated white and black normotensive (n = 61) and hypertensive (n = 23) subjects, studied consecutively in a tertiary referral center. Both race and blood pressure status had independent effects on the distribution of Mg-ion values. Although Mg-ion levels for the group as a whole were lower in hypertensive versus in normotensive subjects (0.571+/-0.012 v 0.601+/-0.005 mmol/L; P < .01), this was only true of white subjects (0.579+/-0.021 v 0.620+/-0.006 mmol/L; P = .0095). The lack of a significant difference in Mg-ion levels between black hypertensive versus normotensive subjects (0.553+/-0.012 v 0.577+/-0.007 mmol/L, P = NS) was attributable to the significantly lower Mg-ion levels present in normotensive blacks compared to those in normotensive white subjects (0.577+/-0.007 v 0.620+/-0.006 mmol/L, P = .0001). Resultant Ca-ion/Mg-ion ratios were elevated in all black subjects and in white hypertensive subjects. These data support the presence among hypertensives and among black subjects (independently of blood pressure) of a consistent depletion of circulating magnesium and of an imbalance of calcium and magnesium that may potentiate vascular disease among these subjects. SN - 0895-7061 UR - http://www.unboundmedicine.com/medline/citation/9443780/Serum_ionized_magnesium:_relation_to_blood_pressure_and_racial_factors_ L2 - https://academic.oup.com/ajh/article-lookup/doi/10.1016/s0895-7061(97)00364-6 DB - PRIME DP - Unbound Medicine ER -