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Prevalence of IgA-antigliadin antibodies and IgA-antiendomysium antibodies related to celiac disease in children with Down syndrome.
Pediatrics 1998; 101(2):272-5Ped

Abstract

OBJECTIVE

This study was undertaken to investigate the prevalence of celiac disease in children and adolescents with Down syndrome.

MATERIAL AND METHODS

Forty-three children and adolescents with Down syndrome were screened for IgA-antigliadin antibodies (AGA) and IgA-antiendomysium antibodies (EMA). Patients found to be either AGA- or EMA-positive were investigated further with intestinal biopsy.

RESULTS

None of the 43 patients had known celiac disease at entry into the study; 37% (16/43) were found to have AGA levels above normal, and 16% (7/43) to be EMA-positive. Of the 15 patients who underwent biopsy, 8 manifested villous atrophy. Villous atrophy was present in all 7 of the EMA-positive patients, whereas the villi were normal in 7 of the 13 AGA-positive patients who underwent biopsy.

CONCLUSIONS

EMA is a good immunologic marker for use in screening for celiac disease, and screening is justified in patients with Down syndrome.

Authors+Show Affiliations

Department of Pediatrics, University of Lund, University Hospital, Malmö, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9445503

Citation

Carlsson, A, et al. "Prevalence of IgA-antigliadin Antibodies and IgA-antiendomysium Antibodies Related to Celiac Disease in Children With Down Syndrome." Pediatrics, vol. 101, no. 2, 1998, pp. 272-5.
Carlsson A, Axelsson I, Borulf S, et al. Prevalence of IgA-antigliadin antibodies and IgA-antiendomysium antibodies related to celiac disease in children with Down syndrome. Pediatrics. 1998;101(2):272-5.
Carlsson, A., Axelsson, I., Borulf, S., Bredberg, A., Forslund, M., Lindberg, B., ... Ivarsson, S. A. (1998). Prevalence of IgA-antigliadin antibodies and IgA-antiendomysium antibodies related to celiac disease in children with Down syndrome. Pediatrics, 101(2), pp. 272-5.
Carlsson A, et al. Prevalence of IgA-antigliadin Antibodies and IgA-antiendomysium Antibodies Related to Celiac Disease in Children With Down Syndrome. Pediatrics. 1998;101(2):272-5. PubMed PMID: 9445503.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of IgA-antigliadin antibodies and IgA-antiendomysium antibodies related to celiac disease in children with Down syndrome. AU - Carlsson,A, AU - Axelsson,I, AU - Borulf,S, AU - Bredberg,A, AU - Forslund,M, AU - Lindberg,B, AU - Sjöberg,K, AU - Ivarsson,S A, PY - 1998/1/31/pubmed PY - 1998/1/31/medline PY - 1998/1/31/entrez SP - 272 EP - 5 JF - Pediatrics JO - Pediatrics VL - 101 IS - 2 N2 - OBJECTIVE: This study was undertaken to investigate the prevalence of celiac disease in children and adolescents with Down syndrome. MATERIAL AND METHODS: Forty-three children and adolescents with Down syndrome were screened for IgA-antigliadin antibodies (AGA) and IgA-antiendomysium antibodies (EMA). Patients found to be either AGA- or EMA-positive were investigated further with intestinal biopsy. RESULTS: None of the 43 patients had known celiac disease at entry into the study; 37% (16/43) were found to have AGA levels above normal, and 16% (7/43) to be EMA-positive. Of the 15 patients who underwent biopsy, 8 manifested villous atrophy. Villous atrophy was present in all 7 of the EMA-positive patients, whereas the villi were normal in 7 of the 13 AGA-positive patients who underwent biopsy. CONCLUSIONS: EMA is a good immunologic marker for use in screening for celiac disease, and screening is justified in patients with Down syndrome. SN - 1098-4275 UR - https://www.unboundmedicine.com/medline/citation/9445503/Prevalence_of_IgA_antigliadin_antibodies_and_IgA_antiendomysium_antibodies_related_to_celiac_disease_in_children_with_Down_syndrome_ L2 - http://pediatrics.aappublications.org/cgi/pmidlookup?view=long&pmid=9445503 DB - PRIME DP - Unbound Medicine ER -