Tags

Type your tag names separated by a space and hit enter

[Malignant hyperthermia and sevoflurane--a case report].

Abstract

The authors report on a course of malignant hyperthermia (MH) in an almost 5-years old boy. In the past, he had been anaesthetized two times with halothane without complications. The causative triggering agent was sevoflurane, a new user-friendly substance for paediatric anaesthesia. Forty five minutes after induction of anaesthesia he developed symptoms of a MH-crisis with increase in endexspiratory CO2 up 87 mmHg and followed by an increase in heart rate up to 160 beats/minute. The blood gas analysis showed a respiratory and metabolic acidosis. The timely administration of dantrolene rapidly reversed the life-threatening signs and prevent progression of the disease. It is apparent that monitoring of endtidal carbon dioxide by means of capnometry is of crucial importance in detecting MH at an early stage, and appropriate treatment is being instituted more promptly. By such early recognition, and treatment with dantrolene, we can reasonably except a further decrease in mortality and morbidity of this enigmatic disorder.

Authors+Show Affiliations

Krankenhaus am Rosarium GmbH Abteilung für Anästhesiologie und Intensivtherapie, Sangerhausen.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

ger

PubMed ID

9445566

Citation

Claussen, D, et al. "[Malignant Hyperthermia and Sevoflurane--a Case Report]." Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, vol. 32, no. 10, 1997, pp. 641-4.
Claussen D, Wuttig K, Freudenberg J, et al. [Malignant hyperthermia and sevoflurane--a case report]. Anasthesiol Intensivmed Notfallmed Schmerzther. 1997;32(10):641-4.
Claussen, D., Wuttig, K., Freudenberg, J., & Claussen, A. (1997). [Malignant hyperthermia and sevoflurane--a case report]. Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 32(10), 641-4.
Claussen D, et al. [Malignant Hyperthermia and Sevoflurane--a Case Report]. Anasthesiol Intensivmed Notfallmed Schmerzther. 1997;32(10):641-4. PubMed PMID: 9445566.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Malignant hyperthermia and sevoflurane--a case report]. AU - Claussen,D, AU - Wuttig,K, AU - Freudenberg,J, AU - Claussen,A, PY - 1998/1/31/pubmed PY - 1998/1/31/medline PY - 1998/1/31/entrez SP - 641 EP - 4 JF - Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS JO - Anasthesiol Intensivmed Notfallmed Schmerzther VL - 32 IS - 10 N2 - The authors report on a course of malignant hyperthermia (MH) in an almost 5-years old boy. In the past, he had been anaesthetized two times with halothane without complications. The causative triggering agent was sevoflurane, a new user-friendly substance for paediatric anaesthesia. Forty five minutes after induction of anaesthesia he developed symptoms of a MH-crisis with increase in endexspiratory CO2 up 87 mmHg and followed by an increase in heart rate up to 160 beats/minute. The blood gas analysis showed a respiratory and metabolic acidosis. The timely administration of dantrolene rapidly reversed the life-threatening signs and prevent progression of the disease. It is apparent that monitoring of endtidal carbon dioxide by means of capnometry is of crucial importance in detecting MH at an early stage, and appropriate treatment is being instituted more promptly. By such early recognition, and treatment with dantrolene, we can reasonably except a further decrease in mortality and morbidity of this enigmatic disorder. SN - 0939-2661 UR - https://www.unboundmedicine.com/medline/citation/9445566/[Malignant_hyperthermia_and_sevoflurane__a_case_report]_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2007-995126 DB - PRIME DP - Unbound Medicine ER -