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Rapid and simple determination of methamphetamine and amphetamine in blood by simultaneous extraction-derivation.
J Pharm Biomed Anal. 1997 Sep; 16(1):139-45.JP

Abstract

A method capable of extracting and derivatizing methamphetamine (MA) and amphetamine (AM) in blood simultaneously was developed. In this method ethyl acetate, triethylamine and pentafluorobenzyl bromide were added to blood, the extraction and pentafluorobenzyl derivatization of MA and AM were performed simultaneously by heating and stirring on a hot place stirrer. Pentafluorobenzyl derivatives were determined by gas chromatography/chemical ionization-mass spectrometry (GC/CI-MS). Deuterium labeled MA and AM were used as internal standards. This method enabled an accurate and precise quantitative analysis from blood containing MA and AM. Excellent results were obtained for autopsy cases with possible MA.

Authors+Show Affiliations

Scientific Investigation Research Laboratory, Aichi Pref. Police H.Q., Nagoya, Japan.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9447561

Citation

Sato, M, and T Mitsui. "Rapid and Simple Determination of Methamphetamine and Amphetamine in Blood By Simultaneous Extraction-derivation." Journal of Pharmaceutical and Biomedical Analysis, vol. 16, no. 1, 1997, pp. 139-45.
Sato M, Mitsui T. Rapid and simple determination of methamphetamine and amphetamine in blood by simultaneous extraction-derivation. J Pharm Biomed Anal. 1997;16(1):139-45.
Sato, M., & Mitsui, T. (1997). Rapid and simple determination of methamphetamine and amphetamine in blood by simultaneous extraction-derivation. Journal of Pharmaceutical and Biomedical Analysis, 16(1), 139-45.
Sato M, Mitsui T. Rapid and Simple Determination of Methamphetamine and Amphetamine in Blood By Simultaneous Extraction-derivation. J Pharm Biomed Anal. 1997;16(1):139-45. PubMed PMID: 9447561.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rapid and simple determination of methamphetamine and amphetamine in blood by simultaneous extraction-derivation. AU - Sato,M, AU - Mitsui,T, PY - 1998/2/3/pubmed PY - 1998/2/3/medline PY - 1998/2/3/entrez SP - 139 EP - 45 JF - Journal of pharmaceutical and biomedical analysis JO - J Pharm Biomed Anal VL - 16 IS - 1 N2 - A method capable of extracting and derivatizing methamphetamine (MA) and amphetamine (AM) in blood simultaneously was developed. In this method ethyl acetate, triethylamine and pentafluorobenzyl bromide were added to blood, the extraction and pentafluorobenzyl derivatization of MA and AM were performed simultaneously by heating and stirring on a hot place stirrer. Pentafluorobenzyl derivatives were determined by gas chromatography/chemical ionization-mass spectrometry (GC/CI-MS). Deuterium labeled MA and AM were used as internal standards. This method enabled an accurate and precise quantitative analysis from blood containing MA and AM. Excellent results were obtained for autopsy cases with possible MA. SN - 0731-7085 UR - https://www.unboundmedicine.com/medline/citation/9447561/Rapid_and_simple_determination_of_methamphetamine_and_amphetamine_in_blood_by_simultaneous_extraction_derivation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0731708597000125 DB - PRIME DP - Unbound Medicine ER -