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Fecal hydrogen sulfide production in ulcerative colitis.
Am J Gastroenterol 1998; 93(1):83-7AJ

Abstract

OBJECTIVE

Sulfide, a product of sulfate-reducing bacteria, has been proposed to play an etiologic role in ulcerative colitis. Ulcerative colitis feces have increased numbers and activity of sulfate-reducing bacteria, but only modestly increased sulfide. However, fecal sulfide exists largely in the volatile, highly toxic H2S form that moves rapidly from feces to surrounding gas. Our aim was to quantify the fecal release of H2S and other volatiles (CO2, H2, CH4, methanethiol, and dimethylsulfide).

METHODS

Fecal samples from 25 subjects with ulcerative colitis and 17 controls were incubated in 4-L containers, and gas release was assessed at intervals over 24 h.

RESULTS

H2S release by ulcerative colitis feces was elevated 3-4-fold at every measurement point compared with normal feces (p < 0.003 at 24 h). The only other significant difference was increased CO2 release by ulcerative colitis feces at 1 h. Supplementation of fecal homogenates with sulfur-containing substrates showed that organic compounds (mucin, cysteine, taurocholate) provided more readily utilizable substrate for H2S production than did sulfate.

CONCLUSIONS

Increased H2S release is a relatively localized metabolic aberration of ulcerative colitis feces. This increased H2S may reflect abnormalities of the fecal bacteria and/or substrate availability.

Authors+Show Affiliations

Department of Medicine, Minneapolis VA Medical Center and University of Minnesota Medical School, 55417, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

9448181

Citation

Levine, J, et al. "Fecal Hydrogen Sulfide Production in Ulcerative Colitis." The American Journal of Gastroenterology, vol. 93, no. 1, 1998, pp. 83-7.
Levine J, Ellis CJ, Furne JK, et al. Fecal hydrogen sulfide production in ulcerative colitis. Am J Gastroenterol. 1998;93(1):83-7.
Levine, J., Ellis, C. J., Furne, J. K., Springfield, J., & Levitt, M. D. (1998). Fecal hydrogen sulfide production in ulcerative colitis. The American Journal of Gastroenterology, 93(1), pp. 83-7.
Levine J, et al. Fecal Hydrogen Sulfide Production in Ulcerative Colitis. Am J Gastroenterol. 1998;93(1):83-7. PubMed PMID: 9448181.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fecal hydrogen sulfide production in ulcerative colitis. AU - Levine,J, AU - Ellis,C J, AU - Furne,J K, AU - Springfield,J, AU - Levitt,M D, PY - 1998/2/3/pubmed PY - 1998/2/3/medline PY - 1998/2/3/entrez SP - 83 EP - 7 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 93 IS - 1 N2 - OBJECTIVE: Sulfide, a product of sulfate-reducing bacteria, has been proposed to play an etiologic role in ulcerative colitis. Ulcerative colitis feces have increased numbers and activity of sulfate-reducing bacteria, but only modestly increased sulfide. However, fecal sulfide exists largely in the volatile, highly toxic H2S form that moves rapidly from feces to surrounding gas. Our aim was to quantify the fecal release of H2S and other volatiles (CO2, H2, CH4, methanethiol, and dimethylsulfide). METHODS: Fecal samples from 25 subjects with ulcerative colitis and 17 controls were incubated in 4-L containers, and gas release was assessed at intervals over 24 h. RESULTS: H2S release by ulcerative colitis feces was elevated 3-4-fold at every measurement point compared with normal feces (p < 0.003 at 24 h). The only other significant difference was increased CO2 release by ulcerative colitis feces at 1 h. Supplementation of fecal homogenates with sulfur-containing substrates showed that organic compounds (mucin, cysteine, taurocholate) provided more readily utilizable substrate for H2S production than did sulfate. CONCLUSIONS: Increased H2S release is a relatively localized metabolic aberration of ulcerative colitis feces. This increased H2S may reflect abnormalities of the fecal bacteria and/or substrate availability. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/9448181/Fecal_hydrogen_sulfide_production_in_ulcerative_colitis_ L2 - http://Insights.ovid.com/pubmed?pmid=9448181 DB - PRIME DP - Unbound Medicine ER -