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Enteral nutrition is superior to parenteral nutrition in severe acute pancreatitis: results of a randomized prospective trial.
Br J Surg. 1997 Dec; 84(12):1665-9.BJ

Abstract

BACKGROUND

Parenteral nutrition is well established for providing nutritional support in acute pancreatitis while avoiding pancreatic stimulation. However, it is associated with complications and high cost. Benefits of enteral feeding in other disease states prompted a comparison of early enteral feeding with total parenteral nutrition in this clinical setting.

METHODS

Thirty-eight patients with acute severe pancreatitis were randomized into two groups. The first (n = 18) received enteral nutrition through a nasoenteric tube with a semi-elemental diet, while the second group (n = 20) received parenteral nutrition through a central venous catheter. Safety was assessed by clinical course of disease, laboratory findings and incidence of complications. Efficacy was determined by nitrogen balance. The cost of nutritional support was calculated.

RESULTS

Enteral feeding was well tolerated without adverse effects on the course of the disease. Patients who received enteral feeding experienced fewer total complications (P < 0.05) and were at lower risk of developing septic complications (P < 0.01) than those receiving parenteral nutrition. The cost of nutritional support was three times higher in patients who received parenteral nutrition.

CONCLUSION

This study suggests that early enteral nutrition should be used preferentially in patients with severe acute pancreatitis.

Authors+Show Affiliations

Department of Surgery, University of Patras, Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

9448611

Citation

Kalfarentzos, F, et al. "Enteral Nutrition Is Superior to Parenteral Nutrition in Severe Acute Pancreatitis: Results of a Randomized Prospective Trial." The British Journal of Surgery, vol. 84, no. 12, 1997, pp. 1665-9.
Kalfarentzos F, Kehagias J, Mead N, et al. Enteral nutrition is superior to parenteral nutrition in severe acute pancreatitis: results of a randomized prospective trial. Br J Surg. 1997;84(12):1665-9.
Kalfarentzos, F., Kehagias, J., Mead, N., Kokkinis, K., & Gogos, C. A. (1997). Enteral nutrition is superior to parenteral nutrition in severe acute pancreatitis: results of a randomized prospective trial. The British Journal of Surgery, 84(12), 1665-9.
Kalfarentzos F, et al. Enteral Nutrition Is Superior to Parenteral Nutrition in Severe Acute Pancreatitis: Results of a Randomized Prospective Trial. Br J Surg. 1997;84(12):1665-9. PubMed PMID: 9448611.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enteral nutrition is superior to parenteral nutrition in severe acute pancreatitis: results of a randomized prospective trial. AU - Kalfarentzos,F, AU - Kehagias,J, AU - Mead,N, AU - Kokkinis,K, AU - Gogos,C A, PY - 1998/2/4/pubmed PY - 1998/2/4/medline PY - 1998/2/4/entrez SP - 1665 EP - 9 JF - The British journal of surgery JO - Br J Surg VL - 84 IS - 12 N2 - BACKGROUND: Parenteral nutrition is well established for providing nutritional support in acute pancreatitis while avoiding pancreatic stimulation. However, it is associated with complications and high cost. Benefits of enteral feeding in other disease states prompted a comparison of early enteral feeding with total parenteral nutrition in this clinical setting. METHODS: Thirty-eight patients with acute severe pancreatitis were randomized into two groups. The first (n = 18) received enteral nutrition through a nasoenteric tube with a semi-elemental diet, while the second group (n = 20) received parenteral nutrition through a central venous catheter. Safety was assessed by clinical course of disease, laboratory findings and incidence of complications. Efficacy was determined by nitrogen balance. The cost of nutritional support was calculated. RESULTS: Enteral feeding was well tolerated without adverse effects on the course of the disease. Patients who received enteral feeding experienced fewer total complications (P < 0.05) and were at lower risk of developing septic complications (P < 0.01) than those receiving parenteral nutrition. The cost of nutritional support was three times higher in patients who received parenteral nutrition. CONCLUSION: This study suggests that early enteral nutrition should be used preferentially in patients with severe acute pancreatitis. SN - 0007-1323 UR - https://www.unboundmedicine.com/medline/citation/9448611/Enteral_nutrition_is_superior_to_parenteral_nutrition_in_severe_acute_pancreatitis:_results_of_a_randomized_prospective_trial_ DB - PRIME DP - Unbound Medicine ER -