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Macrophage colony-stimulating factor as a marker for malignant germ cell tumors of the ovary.
Gynecol Oncol. 1998 Jan; 68(1):35-7.GO

Abstract

We assessed the usefulness of macrophage colony-stimulating factor (M-CSF) as a serum marker for malignant germ cell tumors of the ovary. Serum levels of M-CSF were measured in 49 patients with malignant germ cell tumors and in 64 patients with mature benign cystic teratoma by an enzyme-linked immunosorbent assay. CA125 was measured by radioimmunoassay. The serum level of M-CSF was above normal (>1056 U/ml) in 44 (90%) of 49 patients with malignant germ cell tumors; the CA125 level was above the cutoff value (35 U/ml) in 34 patients (69%) (P < 0.05). The serum level of M-CSF was elevated in 20 (87%) of 23 patients with stage I disease and in all 16 patients with dysgerminoma. Only 7 (11%) of 64 patients with mature benign cystic teratoma had elevated levels of M-CSF. These results suggest that M-CSF is highly sensitive and specific for malignant germ cell tumors of the ovary, especially for dysgerminoma.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Jichi Medical School, 3311 Yakushiji, Minamikawachi, Kawachi, Tochigi 329-04.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9454657

Citation

Suzuki, M, et al. "Macrophage Colony-stimulating Factor as a Marker for Malignant Germ Cell Tumors of the Ovary." Gynecologic Oncology, vol. 68, no. 1, 1998, pp. 35-7.
Suzuki M, Kobayashi H, Ohwada M, et al. Macrophage colony-stimulating factor as a marker for malignant germ cell tumors of the ovary. Gynecol Oncol. 1998;68(1):35-7.
Suzuki, M., Kobayashi, H., Ohwada, M., Terao, T., & Sato, I. (1998). Macrophage colony-stimulating factor as a marker for malignant germ cell tumors of the ovary. Gynecologic Oncology, 68(1), 35-7.
Suzuki M, et al. Macrophage Colony-stimulating Factor as a Marker for Malignant Germ Cell Tumors of the Ovary. Gynecol Oncol. 1998;68(1):35-7. PubMed PMID: 9454657.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Macrophage colony-stimulating factor as a marker for malignant germ cell tumors of the ovary. AU - Suzuki,M, AU - Kobayashi,H, AU - Ohwada,M, AU - Terao,T, AU - Sato,I, PY - 1998/2/28/pubmed PY - 1998/2/28/medline PY - 1998/2/28/entrez SP - 35 EP - 7 JF - Gynecologic oncology JO - Gynecol Oncol VL - 68 IS - 1 N2 - We assessed the usefulness of macrophage colony-stimulating factor (M-CSF) as a serum marker for malignant germ cell tumors of the ovary. Serum levels of M-CSF were measured in 49 patients with malignant germ cell tumors and in 64 patients with mature benign cystic teratoma by an enzyme-linked immunosorbent assay. CA125 was measured by radioimmunoassay. The serum level of M-CSF was above normal (>1056 U/ml) in 44 (90%) of 49 patients with malignant germ cell tumors; the CA125 level was above the cutoff value (35 U/ml) in 34 patients (69%) (P < 0.05). The serum level of M-CSF was elevated in 20 (87%) of 23 patients with stage I disease and in all 16 patients with dysgerminoma. Only 7 (11%) of 64 patients with mature benign cystic teratoma had elevated levels of M-CSF. These results suggest that M-CSF is highly sensitive and specific for malignant germ cell tumors of the ovary, especially for dysgerminoma. SN - 0090-8258 UR - https://www.unboundmedicine.com/medline/citation/9454657/Macrophage_colony_stimulating_factor_as_a_marker_for_malignant_germ_cell_tumors_of_the_ovary_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-8258(97)94897-6 DB - PRIME DP - Unbound Medicine ER -