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Pharmacokinetic and pharmacodynamic interaction study between midazolam and the macrolide antibiotics, erythromycin, clarithromycin, and the azalide azithromycin.
Int J Clin Pharmacol Ther. 1997 Dec; 35(12):577-9.IJ

Abstract

This report includes a recalculation of the pooled data of 2 pharmacokinetic and pharmacodynamic studies of the interaction between the hypnotic midazolam and the antibiotics erythromycin, clarithromycin (macrolides), and azithromycin (an azalide). Erythromycin and clarithromycin similarly and strikingly impaired the metabolism of midazolam and enhanced its pharmacodynamic activity; little or no effect was found with azithromycin. It was concluded that coadministration of midazolam and azithromycin involves less clinical risk than with the 2 macrolides.

Authors+Show Affiliations

Department of Pharmacology, Pfizer-Mack Development Center, Illertissen, Germany.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

9455717

Citation

Yeates, R A., et al. "Pharmacokinetic and Pharmacodynamic Interaction Study Between Midazolam and the Macrolide Antibiotics, Erythromycin, Clarithromycin, and the Azalide Azithromycin." International Journal of Clinical Pharmacology and Therapeutics, vol. 35, no. 12, 1997, pp. 577-9.
Yeates RA, Laufen H, Zimmermann T, et al. Pharmacokinetic and pharmacodynamic interaction study between midazolam and the macrolide antibiotics, erythromycin, clarithromycin, and the azalide azithromycin. Int J Clin Pharmacol Ther. 1997;35(12):577-9.
Yeates, R. A., Laufen, H., Zimmermann, T., & Schumacher, T. (1997). Pharmacokinetic and pharmacodynamic interaction study between midazolam and the macrolide antibiotics, erythromycin, clarithromycin, and the azalide azithromycin. International Journal of Clinical Pharmacology and Therapeutics, 35(12), 577-9.
Yeates RA, et al. Pharmacokinetic and Pharmacodynamic Interaction Study Between Midazolam and the Macrolide Antibiotics, Erythromycin, Clarithromycin, and the Azalide Azithromycin. Int J Clin Pharmacol Ther. 1997;35(12):577-9. PubMed PMID: 9455717.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacokinetic and pharmacodynamic interaction study between midazolam and the macrolide antibiotics, erythromycin, clarithromycin, and the azalide azithromycin. AU - Yeates,R A, AU - Laufen,H, AU - Zimmermann,T, AU - Schumacher,T, PY - 1998/2/10/pubmed PY - 1998/2/10/medline PY - 1998/2/10/entrez SP - 577 EP - 9 JF - International journal of clinical pharmacology and therapeutics JO - Int J Clin Pharmacol Ther VL - 35 IS - 12 N2 - This report includes a recalculation of the pooled data of 2 pharmacokinetic and pharmacodynamic studies of the interaction between the hypnotic midazolam and the antibiotics erythromycin, clarithromycin (macrolides), and azithromycin (an azalide). Erythromycin and clarithromycin similarly and strikingly impaired the metabolism of midazolam and enhanced its pharmacodynamic activity; little or no effect was found with azithromycin. It was concluded that coadministration of midazolam and azithromycin involves less clinical risk than with the 2 macrolides. SN - 0946-1965 UR - https://www.unboundmedicine.com/medline/citation/9455717/Pharmacokinetic_and_pharmacodynamic_interaction_study_between_midazolam_and_the_macrolide_antibiotics_erythromycin_clarithromycin_and_the_azalide_azithromycin_ L2 - https://medlineplus.gov/antibiotics.html DB - PRIME DP - Unbound Medicine ER -