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Effect of post-treatment with granulocyte colony-stimulating factor on endotoxin-induced lung injury in sheep.
Exp Lung Res. 1998 Jan-Feb; 24(1):15-25.EL

Abstract

We administered a bolus of G-CSF (250 micrograms/body) just after the infusion of endotoxin (1 microgram/kg) in awake sheep with chronic lung lymph fistula to examine the effect of post-treatment with G-CSF on endotoxin-induced lung injury. We measured pulmonary hemodynamics, lung lymph flow, and concentrations of thromboxane B2 and 6-keto-prostaglandin F1 alpha in plasma and lung lymph. In the G-CSF post-treated group, the pulmonary arterial pressure, pulmonary vascular resistance, and lung lymph flow did not significantly increase in the late period (3-5 h after endotoxin infusion). The arterial oxygen gas tension in the late period was higher in the G-CSF post-treated sheep than in those that received only endotoxin. Although the level of thromboxane B2 in plasma significantly increased at 1 h after endotoxin, the lung lymph flow did not increase much in the G-CSF post-treated group. We conclude that post-treatment with G-CSF instead attenuates the degree of pulmonary vascular leakage on endotoxin-induced lung injury and increased thromboxane B2, the principle metabolite of thromboxane A2, may not exacerbate the injury in awake sheep.

Authors+Show Affiliations

First Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9457466

Citation

Hanaoka, M, et al. "Effect of Post-treatment With Granulocyte Colony-stimulating Factor On Endotoxin-induced Lung Injury in Sheep." Experimental Lung Research, vol. 24, no. 1, 1998, pp. 15-25.
Hanaoka M, Kubo K, Miyahara T, et al. Effect of post-treatment with granulocyte colony-stimulating factor on endotoxin-induced lung injury in sheep. Exp Lung Res. 1998;24(1):15-25.
Hanaoka, M., Kubo, K., Miyahara, T., Hayano, T., Koizumi, T., Kobayashi, T., & Sekiguchi, M. (1998). Effect of post-treatment with granulocyte colony-stimulating factor on endotoxin-induced lung injury in sheep. Experimental Lung Research, 24(1), 15-25.
Hanaoka M, et al. Effect of Post-treatment With Granulocyte Colony-stimulating Factor On Endotoxin-induced Lung Injury in Sheep. Exp Lung Res. 1998 Jan-Feb;24(1):15-25. PubMed PMID: 9457466.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of post-treatment with granulocyte colony-stimulating factor on endotoxin-induced lung injury in sheep. AU - Hanaoka,M, AU - Kubo,K, AU - Miyahara,T, AU - Hayano,T, AU - Koizumi,T, AU - Kobayashi,T, AU - Sekiguchi,M, PY - 1998/2/11/pubmed PY - 1998/2/11/medline PY - 1998/2/11/entrez SP - 15 EP - 25 JF - Experimental lung research JO - Exp Lung Res VL - 24 IS - 1 N2 - We administered a bolus of G-CSF (250 micrograms/body) just after the infusion of endotoxin (1 microgram/kg) in awake sheep with chronic lung lymph fistula to examine the effect of post-treatment with G-CSF on endotoxin-induced lung injury. We measured pulmonary hemodynamics, lung lymph flow, and concentrations of thromboxane B2 and 6-keto-prostaglandin F1 alpha in plasma and lung lymph. In the G-CSF post-treated group, the pulmonary arterial pressure, pulmonary vascular resistance, and lung lymph flow did not significantly increase in the late period (3-5 h after endotoxin infusion). The arterial oxygen gas tension in the late period was higher in the G-CSF post-treated sheep than in those that received only endotoxin. Although the level of thromboxane B2 in plasma significantly increased at 1 h after endotoxin, the lung lymph flow did not increase much in the G-CSF post-treated group. We conclude that post-treatment with G-CSF instead attenuates the degree of pulmonary vascular leakage on endotoxin-induced lung injury and increased thromboxane B2, the principle metabolite of thromboxane A2, may not exacerbate the injury in awake sheep. SN - 0190-2148 UR - https://www.unboundmedicine.com/medline/citation/9457466/Effect_of_post_treatment_with_granulocyte_colony_stimulating_factor_on_endotoxin_induced_lung_injury_in_sheep_ L2 - https://www.tandfonline.com/doi/full/10.3109/01902149809046051 DB - PRIME DP - Unbound Medicine ER -