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Mutation of the multiple endocrine neoplasia type 1 gene in nonfamilial, malignant tumors of the endocrine pancreas.
Cancer Res. 1998 Feb 01; 58(3):377-9.CR

Abstract

Endocrine pancreatic tumors are rare neoplasms that occur sporadically or as part of a multiple endocrine neoplasia type 1 (MEN1) syndrome. Germ-line mutations of the MEN1 gene, located at 11q13, have been demonstrated in MEN1 kindreds, and loss of heterozygosity (LOH) on 11q13 together with somatic MEN1 mutations have been detected in 20% of nonfamilial parathyroid tumors. Here, we examine 11 non-MEN1 malignant tumors of the endocrine pancreas, 9 nonfunctioning tumors, and 2 glucagonomas. LOH of at least one informative locus on 11q13 was found in 70% of the tumors. Three tumors displayed somatic mutations of the MEN1 gene together with LOH on 11q13, whereas the corresponding germ-line DNA was normal. These findings support the hypothesis that MEN1 gene mutations contribute to the tumorigenesis of nonfamilial, malignant endocrine pancreatic tumors.

Authors+Show Affiliations

Department of Surgery, University Hospital, Uppsala, Sweden. ola.hessman@kirurgi.uu.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9458074

Citation

Hessman, O, et al. "Mutation of the Multiple Endocrine Neoplasia Type 1 Gene in Nonfamilial, Malignant Tumors of the Endocrine Pancreas." Cancer Research, vol. 58, no. 3, 1998, pp. 377-9.
Hessman O, Lindberg D, Skogseid B, et al. Mutation of the multiple endocrine neoplasia type 1 gene in nonfamilial, malignant tumors of the endocrine pancreas. Cancer Res. 1998;58(3):377-9.
Hessman, O., Lindberg, D., Skogseid, B., Carling, T., Hellman, P., Rastad, J., Akerström, G., & Westin, G. (1998). Mutation of the multiple endocrine neoplasia type 1 gene in nonfamilial, malignant tumors of the endocrine pancreas. Cancer Research, 58(3), 377-9.
Hessman O, et al. Mutation of the Multiple Endocrine Neoplasia Type 1 Gene in Nonfamilial, Malignant Tumors of the Endocrine Pancreas. Cancer Res. 1998 Feb 1;58(3):377-9. PubMed PMID: 9458074.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mutation of the multiple endocrine neoplasia type 1 gene in nonfamilial, malignant tumors of the endocrine pancreas. AU - Hessman,O, AU - Lindberg,D, AU - Skogseid,B, AU - Carling,T, AU - Hellman,P, AU - Rastad,J, AU - Akerström,G, AU - Westin,G, PY - 1998/2/11/pubmed PY - 1998/2/11/medline PY - 1998/2/11/entrez SP - 377 EP - 9 JF - Cancer research JO - Cancer Res VL - 58 IS - 3 N2 - Endocrine pancreatic tumors are rare neoplasms that occur sporadically or as part of a multiple endocrine neoplasia type 1 (MEN1) syndrome. Germ-line mutations of the MEN1 gene, located at 11q13, have been demonstrated in MEN1 kindreds, and loss of heterozygosity (LOH) on 11q13 together with somatic MEN1 mutations have been detected in 20% of nonfamilial parathyroid tumors. Here, we examine 11 non-MEN1 malignant tumors of the endocrine pancreas, 9 nonfunctioning tumors, and 2 glucagonomas. LOH of at least one informative locus on 11q13 was found in 70% of the tumors. Three tumors displayed somatic mutations of the MEN1 gene together with LOH on 11q13, whereas the corresponding germ-line DNA was normal. These findings support the hypothesis that MEN1 gene mutations contribute to the tumorigenesis of nonfamilial, malignant endocrine pancreatic tumors. SN - 0008-5472 UR - https://www.unboundmedicine.com/medline/citation/9458074/Mutation_of_the_multiple_endocrine_neoplasia_type_1_gene_in_nonfamilial_malignant_tumors_of_the_endocrine_pancreas_ L2 - http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=9458074 DB - PRIME DP - Unbound Medicine ER -