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Hypomagnesemia: renal magnesium handling.
Semin Nephrol 1998; 18(1):58-73SN

Abstract

Magnesium is an important constituent of the intracellular space that affects a number of intracellular and whole body functions. Magnesium balance depends on intake and renal excretion, which is regulated mainly in the thick ascending limb of the loop of Henle. The complex hormonal modulation that responds to changes in plasma concentration of other ions such as calcium and potassium is lacking for magnesium. As a result, negative magnesium balance results in a prompt decrease in plasma magnesium concentration, and hypermagnesemia accompanies renal failure with magnesium accumulation. Hypomagnesemia may result from gastrointestinal losses or renal losses, the latter due to primary renal magnesium wasting or in association with sodium loss. Hypomagnesemia may arise together with and contribute to the persistence of hypokalemia and hypocalcemia. The major direct toxicity of hypomagnesemia is cardiovascular. When urgent correction of hypomagnesemia is required, as with myocardial ischemia, post cardiopulmonary bypass, and torsades de pointes, intravenous or intramuscular magnesium sulfate should be used. Oral magnesium preparations are available for chronic use.

Authors+Show Affiliations

Renal Electrolyte Division, Hospital of the University of Pennsylvania, University of Pennsylvania School of Medicine, Philadelphia, USA.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

9459289

Citation

Kelepouris, E, and Z S. Agus. "Hypomagnesemia: Renal Magnesium Handling." Seminars in Nephrology, vol. 18, no. 1, 1998, pp. 58-73.
Kelepouris E, Agus ZS. Hypomagnesemia: renal magnesium handling. Semin Nephrol. 1998;18(1):58-73.
Kelepouris, E., & Agus, Z. S. (1998). Hypomagnesemia: renal magnesium handling. Seminars in Nephrology, 18(1), pp. 58-73.
Kelepouris E, Agus ZS. Hypomagnesemia: Renal Magnesium Handling. Semin Nephrol. 1998;18(1):58-73. PubMed PMID: 9459289.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypomagnesemia: renal magnesium handling. AU - Kelepouris,E, AU - Agus,Z S, PY - 1998/2/12/pubmed PY - 1998/2/12/medline PY - 1998/2/12/entrez SP - 58 EP - 73 JF - Seminars in nephrology JO - Semin. Nephrol. VL - 18 IS - 1 N2 - Magnesium is an important constituent of the intracellular space that affects a number of intracellular and whole body functions. Magnesium balance depends on intake and renal excretion, which is regulated mainly in the thick ascending limb of the loop of Henle. The complex hormonal modulation that responds to changes in plasma concentration of other ions such as calcium and potassium is lacking for magnesium. As a result, negative magnesium balance results in a prompt decrease in plasma magnesium concentration, and hypermagnesemia accompanies renal failure with magnesium accumulation. Hypomagnesemia may result from gastrointestinal losses or renal losses, the latter due to primary renal magnesium wasting or in association with sodium loss. Hypomagnesemia may arise together with and contribute to the persistence of hypokalemia and hypocalcemia. The major direct toxicity of hypomagnesemia is cardiovascular. When urgent correction of hypomagnesemia is required, as with myocardial ischemia, post cardiopulmonary bypass, and torsades de pointes, intravenous or intramuscular magnesium sulfate should be used. Oral magnesium preparations are available for chronic use. SN - 0270-9295 UR - https://www.unboundmedicine.com/medline/citation/9459289/Hypomagnesemia:_renal_magnesium_handling_ DB - PRIME DP - Unbound Medicine ER -