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A new flavonol glycoside gallate ester from Acer okamotoanum and its inhibitory activity against human immunodeficiency virus-1 (HIV-1) integrase.
J Nat Prod. 1998 Jan; 61(1):145-8.JN

Abstract

Bioassay-directed chromatographic fractionation of an ethyl acetate extract of the leaves of Acer okamotoanum using HIV-1 integrase afforded a new acylated flavonol glycoside, quercetin 3-O-(2",6"-O-digalloyl)-beta-D-galactopyranoside (1), together with six known flavonol glycosides and three known phenolic compounds. The structure of the new compound was determined by spectroscopic methods. The most active compounds were quercetin 3-O-(2"-galloyl)-alpha-L-arabinopyranoside (6) and 1, which exhibited IC50 values of 18.1 +/- 1.3 and 24.2 +/- 6.6 micrograms/mL, respectively, against HIV-1 integrase.

Authors+Show Affiliations

Division of Applied Science, Korea Institute of Science & Technology, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9461665

Citation

Kim, H J., et al. "A New Flavonol Glycoside Gallate Ester From Acer Okamotoanum and Its Inhibitory Activity Against Human Immunodeficiency Virus-1 (HIV-1) Integrase." Journal of Natural Products, vol. 61, no. 1, 1998, pp. 145-8.
Kim HJ, Woo ER, Shin CG, et al. A new flavonol glycoside gallate ester from Acer okamotoanum and its inhibitory activity against human immunodeficiency virus-1 (HIV-1) integrase. J Nat Prod. 1998;61(1):145-8.
Kim, H. J., Woo, E. R., Shin, C. G., & Park, H. (1998). A new flavonol glycoside gallate ester from Acer okamotoanum and its inhibitory activity against human immunodeficiency virus-1 (HIV-1) integrase. Journal of Natural Products, 61(1), 145-8.
Kim HJ, et al. A New Flavonol Glycoside Gallate Ester From Acer Okamotoanum and Its Inhibitory Activity Against Human Immunodeficiency Virus-1 (HIV-1) Integrase. J Nat Prod. 1998;61(1):145-8. PubMed PMID: 9461665.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A new flavonol glycoside gallate ester from Acer okamotoanum and its inhibitory activity against human immunodeficiency virus-1 (HIV-1) integrase. AU - Kim,H J, AU - Woo,E R, AU - Shin,C G, AU - Park,H, PY - 1998/2/14/pubmed PY - 1998/2/14/medline PY - 1998/2/14/entrez SP - 145 EP - 8 JF - Journal of natural products JO - J Nat Prod VL - 61 IS - 1 N2 - Bioassay-directed chromatographic fractionation of an ethyl acetate extract of the leaves of Acer okamotoanum using HIV-1 integrase afforded a new acylated flavonol glycoside, quercetin 3-O-(2",6"-O-digalloyl)-beta-D-galactopyranoside (1), together with six known flavonol glycosides and three known phenolic compounds. The structure of the new compound was determined by spectroscopic methods. The most active compounds were quercetin 3-O-(2"-galloyl)-alpha-L-arabinopyranoside (6) and 1, which exhibited IC50 values of 18.1 +/- 1.3 and 24.2 +/- 6.6 micrograms/mL, respectively, against HIV-1 integrase. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/9461665/A_new_flavonol_glycoside_gallate_ester_from_Acer_okamotoanum_and_its_inhibitory_activity_against_human_immunodeficiency_virus_1__HIV_1__integrase_ L2 - https://doi.org/10.1021/np970171q DB - PRIME DP - Unbound Medicine ER -