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[Finasteride and flutamide in the treatment of hirsutism].
Minerva Ginecol. 1997 Oct; 49(10):463-8.MG

Abstract

BACKGROUND

The aim of this work was to evaluate the efficacy of two new antiandrogen drugs, finasteride and flutamide, in 80 hirsute patients: 44 with Polycystic Ovary Syndrome (PCOS) and 36 with Idiopathic Hirsutism (IH).

METHODS

The study was conducted in a randomized way and randomization was carried out according to hospitalization. Before and after the treatment, all of the patients underwent hematochemical tests, hormone assays and assessment of hirsutism with the Ferriman Gallway score (F.G. score) and with measurement of the hair diameter in four different body areas. Finasteride was administered per os to 40 women at the dose of 5 mg/die; flutamide per os to 40 women at the dose of 250 mg twice daily. Both drugs were employed for 6 consecutive months.

RESULTS

Both finasteride and flutamide significantly reduced the F.G. score and hair diameter.

CONCLUSIONS

Abdominal hairs were more sensitive to the therapy.

Authors+Show Affiliations

Falsetti L
Dipartimento di Ginecologia Endocrinologica, Università degli Studi, Brescia.
De Fusco D
No affiliation info available
Rosina B
No affiliation info available

MeSH

Administration, OralAdultAndrogen AntagonistsDose-Response Relationship, DrugFemaleFinasterideFlutamideHirsutismHumansHyperandrogenismPolycystic Ovary Syndrome

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
English Abstract
Journal Article
Randomized Controlled Trial

Language

ita

PubMed ID

9463180

Citation

Falsetti, L, et al. "[Finasteride and Flutamide in the Treatment of Hirsutism]." Minerva Ginecologica, vol. 49, no. 10, 1997, pp. 463-8.
Falsetti L, De Fusco D, Rosina B. [Finasteride and flutamide in the treatment of hirsutism]. Minerva Ginecol. 1997;49(10):463-8.
Falsetti, L., De Fusco, D., & Rosina, B. (1997). [Finasteride and flutamide in the treatment of hirsutism]. Minerva Ginecologica, 49(10), 463-8.
Falsetti L, De Fusco D, Rosina B. [Finasteride and Flutamide in the Treatment of Hirsutism]. Minerva Ginecol. 1997;49(10):463-8. PubMed PMID: 9463180.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Finasteride and flutamide in the treatment of hirsutism]. AU - Falsetti,L, AU - De Fusco,D, AU - Rosina,B, PY - 1998/2/14/pubmed PY - 1998/2/14/medline PY - 1998/2/14/entrez SP - 463 EP - 8 JF - Minerva ginecologica JO - Minerva Ginecol VL - 49 IS - 10 N2 - BACKGROUND: The aim of this work was to evaluate the efficacy of two new antiandrogen drugs, finasteride and flutamide, in 80 hirsute patients: 44 with Polycystic Ovary Syndrome (PCOS) and 36 with Idiopathic Hirsutism (IH). METHODS: The study was conducted in a randomized way and randomization was carried out according to hospitalization. Before and after the treatment, all of the patients underwent hematochemical tests, hormone assays and assessment of hirsutism with the Ferriman Gallway score (F.G. score) and with measurement of the hair diameter in four different body areas. Finasteride was administered per os to 40 women at the dose of 5 mg/die; flutamide per os to 40 women at the dose of 250 mg twice daily. Both drugs were employed for 6 consecutive months. RESULTS: Both finasteride and flutamide significantly reduced the F.G. score and hair diameter. CONCLUSIONS: Abdominal hairs were more sensitive to the therapy. SN - 0026-4784 UR - https://www.unboundmedicine.com/medline/citation/9463180/[Finasteride_and_flutamide_in_the_treatment_of_hirsutism]_ L2 - https://medlineplus.gov/polycysticovarysyndrome.html DB - PRIME DP - Unbound Medicine ER -