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[The evaluation of the tolerance and nephrotoxicity of pentavalent antimony administered in a dose of 40 mg Sb V/kg/day, 12/12 hr, for 30 days in the mucocutaneous form of leishmaniasis].
Rev Soc Bras Med Trop. 1997 Nov-Dec; 30(6):457-63.RS

Abstract

The renal function of eleven patients with mucocutaneous leishmaniasis was analyzed in a prospective study realized at the School Hospital of University of Brasília. The patients were treated with doses of 40 mg/kg/day of pentavalent antimony (Sb V), in a continuous scheme during thirty days. In this study three patients were excluded, one patient with reversible renal failure and two patients with hepatic and cardiac malfunctions. In the other eight patients, severe nephrotoxic effects were observed, like reduction of glomerular filtration rate, reduction of the urinary concentration capacity, evaluated by a sixteen hours hydric fasting and an increase of sodium fractional excretion. An increase in the number of leucocytes and cylinders were observed at the urinary sediment exam. Finally, the results shows that the treatment with pentavalent antimony in doses of 40 mg Sb/kg/day was less tolerated on account of its renal toxic effects. This scheme seems not be superior than the currently preconized scheme of 20 mg of Sb V/kg/day during 30 days.

Authors+Show Affiliations

Depto. de Clínica Médica, Faculdade de Ciências da Saúde/UnB. Campus Universitário, Brasília, DF.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

por

PubMed ID

9463192

Citation

Sampaio, R N., et al. "[The Evaluation of the Tolerance and Nephrotoxicity of Pentavalent Antimony Administered in a Dose of 40 Mg Sb V/kg/day, 12/12 Hr, for 30 Days in the Mucocutaneous Form of Leishmaniasis]." Revista Da Sociedade Brasileira De Medicina Tropical, vol. 30, no. 6, 1997, pp. 457-63.
Sampaio RN, de Paula CD, Sampaio JH, et al. [The evaluation of the tolerance and nephrotoxicity of pentavalent antimony administered in a dose of 40 mg Sb V/kg/day, 12/12 hr, for 30 days in the mucocutaneous form of leishmaniasis]. Rev Soc Bras Med Trop. 1997;30(6):457-63.
Sampaio, R. N., de Paula, C. D., Sampaio, J. H., Furtado, R. d. e. . S., Leal, P. P., Rosa, T. T., Rodrigues, M. E., & Veiga, J. P. (1997). [The evaluation of the tolerance and nephrotoxicity of pentavalent antimony administered in a dose of 40 mg Sb V/kg/day, 12/12 hr, for 30 days in the mucocutaneous form of leishmaniasis]. Revista Da Sociedade Brasileira De Medicina Tropical, 30(6), 457-63.
Sampaio RN, et al. [The Evaluation of the Tolerance and Nephrotoxicity of Pentavalent Antimony Administered in a Dose of 40 Mg Sb V/kg/day, 12/12 Hr, for 30 Days in the Mucocutaneous Form of Leishmaniasis]. Rev Soc Bras Med Trop. 1997 Nov-Dec;30(6):457-63. PubMed PMID: 9463192.
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TY - JOUR T1 - [The evaluation of the tolerance and nephrotoxicity of pentavalent antimony administered in a dose of 40 mg Sb V/kg/day, 12/12 hr, for 30 days in the mucocutaneous form of leishmaniasis]. AU - Sampaio,R N, AU - de Paula,C D, AU - Sampaio,J H, AU - Furtado,R de S, AU - Leal,P P, AU - Rosa,T T, AU - Rodrigues,M E, AU - Veiga,J P, PY - 1998/2/14/pubmed PY - 1998/2/14/medline PY - 1998/2/14/entrez SP - 457 EP - 63 JF - Revista da Sociedade Brasileira de Medicina Tropical JO - Rev Soc Bras Med Trop VL - 30 IS - 6 N2 - The renal function of eleven patients with mucocutaneous leishmaniasis was analyzed in a prospective study realized at the School Hospital of University of Brasília. The patients were treated with doses of 40 mg/kg/day of pentavalent antimony (Sb V), in a continuous scheme during thirty days. In this study three patients were excluded, one patient with reversible renal failure and two patients with hepatic and cardiac malfunctions. In the other eight patients, severe nephrotoxic effects were observed, like reduction of glomerular filtration rate, reduction of the urinary concentration capacity, evaluated by a sixteen hours hydric fasting and an increase of sodium fractional excretion. An increase in the number of leucocytes and cylinders were observed at the urinary sediment exam. Finally, the results shows that the treatment with pentavalent antimony in doses of 40 mg Sb/kg/day was less tolerated on account of its renal toxic effects. This scheme seems not be superior than the currently preconized scheme of 20 mg of Sb V/kg/day during 30 days. SN - 0037-8682 UR - https://www.unboundmedicine.com/medline/citation/9463192/[The_evaluation_of_the_tolerance_and_nephrotoxicity_of_pentavalent_antimony_administered_in_a_dose_of_40_mg_Sb_V/kg/day_12/12_hr_for_30_days_in_the_mucocutaneous_form_of_leishmaniasis]_ L2 - https://ClinicalTrials.gov/search/term=9463192 [PUBMED-IDS] DB - PRIME DP - Unbound Medicine ER -