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Human Herpesviridae in acute necrotizing ulcerative gingivitis in children in Nigeria.
Oral Microbiol Immunol. 1997 Oct; 12(5):259-65.OM

Abstract

Herpesviruses have been implicated in the pathogenesis of human periodontitis. The present study investigated whether herpesviruses are present in the lesions of acute necrotizing ulcerative gingivitis. Sixty-two Nigerian children, aged 3-14 years, were studied. Twenty-two children had acute necrotizing ulcerative gingivitis and were also malnourished, 20 exhibited no acute necrotizing ulcerative gingivitis but were malnourished and 20 were free of acute necrotizing ulcerative gingivitis and in a good nutritional state. Polymerase chain reaction methods were used to determine the presence of human cytomegalovirus (HCMV), Epstein-Barr virus type 1 and type 2 (EBV-1, EBV-2), herpes simplex virus (HSV), human herpes virus 6 (HHV-6), human papilloma virus and human immunodeficiency virus type 1 in crevicular fluid specimens collected by paper points. Of the 22 acute necrotizing ulcerative gingivitis patients, 15 (68%) revealed viral infection and 8 (36%) viral coinfection. Thirteen (59%) acute necrotizing ulcerative gingivitis patients demonstrated HCMV, 6 (27%) EBV-1, 5 (23%) HSV and 1 (5%) HHV-6. Only 2 (10%) subjects from each group not affected by acute necrotizing ulcerative gingivitis showed viral presence, and no control subject revealed viral coinfection. These findings suggest that HCMV and possibly other herpesviruses contribute to the onset and/or progression of acute necrotizing ulcerative gingivitis in malnourished Nigerian children.

Authors+Show Affiliations

Department of Periodontology, School of Dentistry, University of Southern California, Los Angeles, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9467378

Citation

Contreras, A, et al. "Human Herpesviridae in Acute Necrotizing Ulcerative Gingivitis in Children in Nigeria." Oral Microbiology and Immunology, vol. 12, no. 5, 1997, pp. 259-65.
Contreras A, Falkler WA, Enwonwu CO, et al. Human Herpesviridae in acute necrotizing ulcerative gingivitis in children in Nigeria. Oral Microbiol Immunol. 1997;12(5):259-65.
Contreras, A., Falkler, W. A., Enwonwu, C. O., Idigbe, E. O., Savage, K. O., Afolabi, M. B., Onwujekwe, D., Rams, T. E., & Slots, J. (1997). Human Herpesviridae in acute necrotizing ulcerative gingivitis in children in Nigeria. Oral Microbiology and Immunology, 12(5), 259-65.
Contreras A, et al. Human Herpesviridae in Acute Necrotizing Ulcerative Gingivitis in Children in Nigeria. Oral Microbiol Immunol. 1997;12(5):259-65. PubMed PMID: 9467378.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human Herpesviridae in acute necrotizing ulcerative gingivitis in children in Nigeria. AU - Contreras,A, AU - Falkler,W A,Jr AU - Enwonwu,C O, AU - Idigbe,E O, AU - Savage,K O, AU - Afolabi,M B, AU - Onwujekwe,D, AU - Rams,T E, AU - Slots,J, PY - 1998/2/19/pubmed PY - 2001/3/28/medline PY - 1998/2/19/entrez KW - Adolescents KW - Africa KW - Africa South Of The Sahara KW - Age Factors KW - Biology KW - Child KW - Clinical Research KW - Demographic Factors KW - Developing Countries KW - Diseases KW - English Speaking Africa KW - Gingivitis--etiology KW - Nigeria KW - Oral Effects--etiology KW - Physiology KW - Population KW - Population Characteristics KW - Research Methodology KW - Research Report KW - Viral Diseases KW - Western Africa KW - Youth SP - 259 EP - 65 JF - Oral microbiology and immunology JO - Oral Microbiol Immunol VL - 12 IS - 5 N2 - Herpesviruses have been implicated in the pathogenesis of human periodontitis. The present study investigated whether herpesviruses are present in the lesions of acute necrotizing ulcerative gingivitis. Sixty-two Nigerian children, aged 3-14 years, were studied. Twenty-two children had acute necrotizing ulcerative gingivitis and were also malnourished, 20 exhibited no acute necrotizing ulcerative gingivitis but were malnourished and 20 were free of acute necrotizing ulcerative gingivitis and in a good nutritional state. Polymerase chain reaction methods were used to determine the presence of human cytomegalovirus (HCMV), Epstein-Barr virus type 1 and type 2 (EBV-1, EBV-2), herpes simplex virus (HSV), human herpes virus 6 (HHV-6), human papilloma virus and human immunodeficiency virus type 1 in crevicular fluid specimens collected by paper points. Of the 22 acute necrotizing ulcerative gingivitis patients, 15 (68%) revealed viral infection and 8 (36%) viral coinfection. Thirteen (59%) acute necrotizing ulcerative gingivitis patients demonstrated HCMV, 6 (27%) EBV-1, 5 (23%) HSV and 1 (5%) HHV-6. Only 2 (10%) subjects from each group not affected by acute necrotizing ulcerative gingivitis showed viral presence, and no control subject revealed viral coinfection. These findings suggest that HCMV and possibly other herpesviruses contribute to the onset and/or progression of acute necrotizing ulcerative gingivitis in malnourished Nigerian children. SN - 0902-0055 UR - https://www.unboundmedicine.com/medline/citation/9467378/Human_Herpesviridae_in_acute_necrotizing_ulcerative_gingivitis_in_children_in_Nigeria_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0902-0055&date=1997&volume=12&issue=5&spage=259 DB - PRIME DP - Unbound Medicine ER -