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Milk thistle (Silybum marianum) for the therapy of liver disease.
Am J Gastroenterol 1998; 93(2):139-43AJ

Abstract

Silymarin, derived from the milk thistle plant, Silybum marianum, has been used for centuries as a natural remedy for diseases of the liver and biliary tract. As interest in alternative therapy has emerged in the United States, gastroenterologists have encountered increasing numbers of patients taking silymarin with little understanding of its purported properties. Silymarin and its active constituent, silybin, have been reported to work as antioxidants scavenging free radicals and inhibiting lipid peroxidation. Studies also suggest that they protect against genomic injury, increase hepatocyte protein synthesis, decrease the activity of tumor promoters, stabilize mast cells, chelate iron, and slow calcium metabolism. In this article we review silymarin's history, pharmacology, and properties, and the clinical trials pertaining to patients with acute and chronic liver disease.

Authors+Show Affiliations

Division of Gastroenterology, Oregon Health Sciences University, Portland 97201-3098, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

9468229

Citation

Flora, K, et al. "Milk Thistle (Silybum Marianum) for the Therapy of Liver Disease." The American Journal of Gastroenterology, vol. 93, no. 2, 1998, pp. 139-43.
Flora K, Hahn M, Rosen H, et al. Milk thistle (Silybum marianum) for the therapy of liver disease. Am J Gastroenterol. 1998;93(2):139-43.
Flora, K., Hahn, M., Rosen, H., & Benner, K. (1998). Milk thistle (Silybum marianum) for the therapy of liver disease. The American Journal of Gastroenterology, 93(2), pp. 139-43.
Flora K, et al. Milk Thistle (Silybum Marianum) for the Therapy of Liver Disease. Am J Gastroenterol. 1998;93(2):139-43. PubMed PMID: 9468229.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Milk thistle (Silybum marianum) for the therapy of liver disease. AU - Flora,K, AU - Hahn,M, AU - Rosen,H, AU - Benner,K, PY - 1998/2/19/pubmed PY - 1998/2/19/medline PY - 1998/2/19/entrez SP - 139 EP - 43 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 93 IS - 2 N2 - Silymarin, derived from the milk thistle plant, Silybum marianum, has been used for centuries as a natural remedy for diseases of the liver and biliary tract. As interest in alternative therapy has emerged in the United States, gastroenterologists have encountered increasing numbers of patients taking silymarin with little understanding of its purported properties. Silymarin and its active constituent, silybin, have been reported to work as antioxidants scavenging free radicals and inhibiting lipid peroxidation. Studies also suggest that they protect against genomic injury, increase hepatocyte protein synthesis, decrease the activity of tumor promoters, stabilize mast cells, chelate iron, and slow calcium metabolism. In this article we review silymarin's history, pharmacology, and properties, and the clinical trials pertaining to patients with acute and chronic liver disease. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/9468229/Milk_thistle__Silybum_marianum__for_the_therapy_of_liver_disease_ L2 - http://Insights.ovid.com/pubmed?pmid=9468229 DB - PRIME DP - Unbound Medicine ER -