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The association of serum anticholinergic activity with delirium in elderly medical patients.
Am J Geriatr Psychiatry. 1998 Winter; 6(1):31-41.AJ

Abstract

To investigate the hypothesis that elevated serum anticholinergic activity is independently associated with delirium in ill elderly persons, the authors performed a cross-sectional study of 67 acutely ill older medical inpatients. The presence of delirium was evaluated with the Confusion Assessment Method, and the presence of many delirium symptoms was measured by the Delirium Symptom Interview. Demographic data and clinical characteristics that may be important for the development of delirium were also collected. Logistic regression techniques demonstrated that elevated serum anticholinergic activity was independently associated with delirium. Among the subjects with delirium, a greater number of delirium symptoms was associated with higher serum anticholinergic activity.

Authors+Show Affiliations

Harvard Medical School Division on Aging, Boston, Massachusetts, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9469212

Citation

Flacker, J M., et al. "The Association of Serum Anticholinergic Activity With Delirium in Elderly Medical Patients." The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry, vol. 6, no. 1, 1998, pp. 31-41.
Flacker JM, Cummings V, Mach JR, et al. The association of serum anticholinergic activity with delirium in elderly medical patients. Am J Geriatr Psychiatry. 1998;6(1):31-41.
Flacker, J. M., Cummings, V., Mach, J. R., Bettin, K., Kiely, D. K., & Wei, J. (1998). The association of serum anticholinergic activity with delirium in elderly medical patients. The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry, 6(1), 31-41.
Flacker JM, et al. The Association of Serum Anticholinergic Activity With Delirium in Elderly Medical Patients. Am J Geriatr Psychiatry. 1998;6(1):31-41. PubMed PMID: 9469212.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The association of serum anticholinergic activity with delirium in elderly medical patients. AU - Flacker,J M, AU - Cummings,V, AU - Mach,J R,Jr AU - Bettin,K, AU - Kiely,D K, AU - Wei,J, PY - 1998/2/20/pubmed PY - 2001/3/28/medline PY - 1998/2/20/entrez SP - 31 EP - 41 JF - The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry JO - Am J Geriatr Psychiatry VL - 6 IS - 1 N2 - To investigate the hypothesis that elevated serum anticholinergic activity is independently associated with delirium in ill elderly persons, the authors performed a cross-sectional study of 67 acutely ill older medical inpatients. The presence of delirium was evaluated with the Confusion Assessment Method, and the presence of many delirium symptoms was measured by the Delirium Symptom Interview. Demographic data and clinical characteristics that may be important for the development of delirium were also collected. Logistic regression techniques demonstrated that elevated serum anticholinergic activity was independently associated with delirium. Among the subjects with delirium, a greater number of delirium symptoms was associated with higher serum anticholinergic activity. SN - 1064-7481 UR - https://www.unboundmedicine.com/medline/citation/9469212/The_association_of_serum_anticholinergic_activity_with_delirium_in_elderly_medical_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1064-7481(12)61007-0 DB - PRIME DP - Unbound Medicine ER -