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Prospective evaluation of vitamin E for hot flashes in breast cancer survivors.
J Clin Oncol. 1998 Feb; 16(2):495-500.JC

Abstract

PURPOSE

Hot flashes represent a substantial clinical problem for some breast cancer survivors. Although estrogen or progesterone preparations can alleviate these symptoms in many patients, concern remains regarding the use of hormonal preparations in such women. Thus, there is a perceived need for nonhormonal treatments for hot flashes for breast cancer survivors. Based on anecdotal evidence that vitamin E was helpful, we designed a trial to investigate this matter.

METHODS

We developed and conducted a placebo-controlled, randomized, crossover trial where, after a 1 week baseline period, patients received 4 weeks of vitamin E 800 IU daily, then 4 weeks of an identical-appearing placebo, or vice versa. Diaries were used to measure potential toxicities and hot flashes during the baseline week and the two subsequent 4-week treatment periods.

RESULTS

The 120 patients evaluated for toxicity failed to show any. The 105 patients who finished the first treatment period showed a similar reduction in hot flash frequencies (25% v 22%; P = .90) for the two study arms. A crossover analysis, however, showed that vitamin E was associated with a minimal decrease in hot flashes (one less hot flash per day than was seen with a placebo) (P < or = .05). At the study end, patients did not prefer vitamin E over the placebo (32% v 29%, respectively).

CONCLUSION

Although this trial was able to show a statistically significant hot flash reduction with vitamin E compared to a placebo, the clinical magnitude of this reduction was marginal.

Authors+Show Affiliations

Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9469333

Citation

Barton, D L., et al. "Prospective Evaluation of Vitamin E for Hot Flashes in Breast Cancer Survivors." Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, vol. 16, no. 2, 1998, pp. 495-500.
Barton DL, Loprinzi CL, Quella SK, et al. Prospective evaluation of vitamin E for hot flashes in breast cancer survivors. J Clin Oncol. 1998;16(2):495-500.
Barton, D. L., Loprinzi, C. L., Quella, S. K., Sloan, J. A., Veeder, M. H., Egner, J. R., Fidler, P., Stella, P. J., Swan, D. K., Vaught, N. L., & Novotny, P. (1998). Prospective evaluation of vitamin E for hot flashes in breast cancer survivors. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, 16(2), 495-500.
Barton DL, et al. Prospective Evaluation of Vitamin E for Hot Flashes in Breast Cancer Survivors. J Clin Oncol. 1998;16(2):495-500. PubMed PMID: 9469333.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prospective evaluation of vitamin E for hot flashes in breast cancer survivors. AU - Barton,D L, AU - Loprinzi,C L, AU - Quella,S K, AU - Sloan,J A, AU - Veeder,M H, AU - Egner,J R, AU - Fidler,P, AU - Stella,P J, AU - Swan,D K, AU - Vaught,N L, AU - Novotny,P, PY - 1998/2/20/pubmed PY - 1998/2/20/medline PY - 1998/2/20/entrez SP - 495 EP - 500 JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology JO - J Clin Oncol VL - 16 IS - 2 N2 - PURPOSE: Hot flashes represent a substantial clinical problem for some breast cancer survivors. Although estrogen or progesterone preparations can alleviate these symptoms in many patients, concern remains regarding the use of hormonal preparations in such women. Thus, there is a perceived need for nonhormonal treatments for hot flashes for breast cancer survivors. Based on anecdotal evidence that vitamin E was helpful, we designed a trial to investigate this matter. METHODS: We developed and conducted a placebo-controlled, randomized, crossover trial where, after a 1 week baseline period, patients received 4 weeks of vitamin E 800 IU daily, then 4 weeks of an identical-appearing placebo, or vice versa. Diaries were used to measure potential toxicities and hot flashes during the baseline week and the two subsequent 4-week treatment periods. RESULTS: The 120 patients evaluated for toxicity failed to show any. The 105 patients who finished the first treatment period showed a similar reduction in hot flash frequencies (25% v 22%; P = .90) for the two study arms. A crossover analysis, however, showed that vitamin E was associated with a minimal decrease in hot flashes (one less hot flash per day than was seen with a placebo) (P < or = .05). At the study end, patients did not prefer vitamin E over the placebo (32% v 29%, respectively). CONCLUSION: Although this trial was able to show a statistically significant hot flash reduction with vitamin E compared to a placebo, the clinical magnitude of this reduction was marginal. SN - 0732-183X UR - https://www.unboundmedicine.com/medline/citation/9469333/Prospective_evaluation_of_vitamin_E_for_hot_flashes_in_breast_cancer_survivors_ L2 - https://ascopubs.org/doi/10.1200/JCO.1998.16.2.495?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -