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Hepatic lipase activity is lower in African American men than in white American men: effects of 5' flanking polymorphism in the hepatic lipase gene (LIPC).
J Lipid Res. 1998 Jan; 39(1):228-32.JL

Abstract

Plasma high density lipoprotein cholesterol (HDL-C) concentrations are higher in African American men than in white men, but the mechanism(s) responsible for this ethnic difference has not been elucidated. This study examined the relationship between hepatic lipase activity, plasma HDL-C concentrations, and a hepatic lipase polymorphism (-514T) in African American and white American men. Consistent with previous reports, plasma HDL-C concentrations were significantly higher in African American men than in white American men. Mean post-heparin plasma hepatic lipase activity was significantly lower in African American than in white American men (27 +/- 12 vs. 44 +/- 17 mmol x h(-1) x l(-1), P < 0.001). The -514T hepatic lipase allele was associated with low hepatic lipase activity in both populations, and was 3-fold more common among African Americans than white Americans. Taken together, these data suggest that genetic differences in hepatic lipase activity contribute to the differences in plasma HDL-C concentrations between African American men and white American men.

Authors+Show Affiliations

The Center for Human Nutrition, Department of Clinical Nutrition, University of Texas Southwestern Medical Center, Dallas 75235-9052, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9469601

Citation

Vega, G L., et al. "Hepatic Lipase Activity Is Lower in African American Men Than in White American Men: Effects of 5' Flanking Polymorphism in the Hepatic Lipase Gene (LIPC)." Journal of Lipid Research, vol. 39, no. 1, 1998, pp. 228-32.
Vega GL, Clark LT, Tang A, et al. Hepatic lipase activity is lower in African American men than in white American men: effects of 5' flanking polymorphism in the hepatic lipase gene (LIPC). J Lipid Res. 1998;39(1):228-32.
Vega, G. L., Clark, L. T., Tang, A., Marcovina, S., Grundy, S. M., & Cohen, J. C. (1998). Hepatic lipase activity is lower in African American men than in white American men: effects of 5' flanking polymorphism in the hepatic lipase gene (LIPC). Journal of Lipid Research, 39(1), 228-32.
Vega GL, et al. Hepatic Lipase Activity Is Lower in African American Men Than in White American Men: Effects of 5' Flanking Polymorphism in the Hepatic Lipase Gene (LIPC). J Lipid Res. 1998;39(1):228-32. PubMed PMID: 9469601.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatic lipase activity is lower in African American men than in white American men: effects of 5' flanking polymorphism in the hepatic lipase gene (LIPC). AU - Vega,G L, AU - Clark,L T, AU - Tang,A, AU - Marcovina,S, AU - Grundy,S M, AU - Cohen,J C, PY - 1998/2/20/pubmed PY - 1998/2/20/medline PY - 1998/2/20/entrez SP - 228 EP - 32 JF - Journal of lipid research JO - J Lipid Res VL - 39 IS - 1 N2 - Plasma high density lipoprotein cholesterol (HDL-C) concentrations are higher in African American men than in white men, but the mechanism(s) responsible for this ethnic difference has not been elucidated. This study examined the relationship between hepatic lipase activity, plasma HDL-C concentrations, and a hepatic lipase polymorphism (-514T) in African American and white American men. Consistent with previous reports, plasma HDL-C concentrations were significantly higher in African American men than in white American men. Mean post-heparin plasma hepatic lipase activity was significantly lower in African American than in white American men (27 +/- 12 vs. 44 +/- 17 mmol x h(-1) x l(-1), P < 0.001). The -514T hepatic lipase allele was associated with low hepatic lipase activity in both populations, and was 3-fold more common among African Americans than white Americans. Taken together, these data suggest that genetic differences in hepatic lipase activity contribute to the differences in plasma HDL-C concentrations between African American men and white American men. SN - 0022-2275 UR - https://www.unboundmedicine.com/medline/citation/9469601/Hepatic_lipase_activity_is_lower_in_African_American_men_than_in_white_American_men:_effects_of_5'_flanking_polymorphism_in_the_hepatic_lipase_gene__LIPC__ L2 - http://www.jlr.org/cgi/pmidlookup?view=long&amp;pmid=9469601 DB - PRIME DP - Unbound Medicine ER -