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A case of feline cryptococcosis treated with itraconazole.
Mycoses. 1997 Dec; 40(9-10):381-3.M

Abstract

We successfully treated a feline case of cryptococcosis with itraconazole (ITZ) at a lower dosage. The patient was a 2-year-old castrated male Abyssinian cat weighing 4.1 kg and with two masses on the head. Clinical signs were sneezing and nasal discharge. The plasma cryptococcal antigen titer measured by the latex agglutination test was proved to be high (512). The biopsy specimen from the masses disclosed yeast cells which were cultured and identified to be Cryptococcus neoformans. The cat was treated with ITZ 5 mg kg-1 given orally once a day with food. After 4 weeks, treatment of ITZ discontinued, because the cat was clinically normal and the antigen titer was low (128). However, about 7 months later, a subcutaneous nodule was detected on the same area. The nasal discharge appeared again, and the cryptococcal antigen titer was 256. ITZ treatment was continued again at the same dosage for 3 months until the antigen titer was negative (< 8). Four months after discontinuation of ITZ, the cat did not relapse and the antigen titer was in the negative range. No side-effects of ITZ were detected by physical and laboratory examination.

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Authors+Show Affiliations

Kano R
Department of Veterinary Internal Medicine, Faculty of Agriculture, University of Tokyo, Japan.
Nakamura Y
No affiliation info available
Watari T
No affiliation info available
Tsujimoto H
No affiliation info available
Hasegawa A
No affiliation info available

MeSH

AnimalsAntifungal AgentsCat DiseasesCatsCryptococcosisItraconazoleMale

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

9470427

Citation

Kano, R, et al. "A Case of Feline Cryptococcosis Treated With Itraconazole." Mycoses, vol. 40, no. 9-10, 1997, pp. 381-3.
Kano R, Nakamura Y, Watari T, et al. A case of feline cryptococcosis treated with itraconazole. Mycoses. 1997;40(9-10):381-3.
Kano, R., Nakamura, Y., Watari, T., Tsujimoto, H., & Hasegawa, A. (1997). A case of feline cryptococcosis treated with itraconazole. Mycoses, 40(9-10), 381-3.
Kano R, et al. A Case of Feline Cryptococcosis Treated With Itraconazole. Mycoses. 1997;40(9-10):381-3. PubMed PMID: 9470427.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A case of feline cryptococcosis treated with itraconazole. AU - Kano,R, AU - Nakamura,Y, AU - Watari,T, AU - Tsujimoto,H, AU - Hasegawa,A, PY - 1998/2/21/pubmed PY - 1998/2/21/medline PY - 1998/2/21/entrez SP - 381 EP - 3 JF - Mycoses JO - Mycoses VL - 40 IS - 9-10 N2 - We successfully treated a feline case of cryptococcosis with itraconazole (ITZ) at a lower dosage. The patient was a 2-year-old castrated male Abyssinian cat weighing 4.1 kg and with two masses on the head. Clinical signs were sneezing and nasal discharge. The plasma cryptococcal antigen titer measured by the latex agglutination test was proved to be high (512). The biopsy specimen from the masses disclosed yeast cells which were cultured and identified to be Cryptococcus neoformans. The cat was treated with ITZ 5 mg kg-1 given orally once a day with food. After 4 weeks, treatment of ITZ discontinued, because the cat was clinically normal and the antigen titer was low (128). However, about 7 months later, a subcutaneous nodule was detected on the same area. The nasal discharge appeared again, and the cryptococcal antigen titer was 256. ITZ treatment was continued again at the same dosage for 3 months until the antigen titer was negative (< 8). Four months after discontinuation of ITZ, the cat did not relapse and the antigen titer was in the negative range. No side-effects of ITZ were detected by physical and laboratory examination. SN - 0933-7407 UR - https://www.unboundmedicine.com/medline/citation/9470427/A_case_of_feline_cryptococcosis_treated_with_itraconazole_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0933-7407&amp;date=1997&amp;volume=40&amp;issue=9-10&amp;spage=381 DB - PRIME DP - Unbound Medicine ER -