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[Use of metformin in the management of adolescents with polycystic ovary syndrome].
Ginecol Obstet Mex. 1997 Dec; 65:504-7.GO

Abstract

Present study was designed to test that insulin resistance due to hyperinsulinism contribute to the clinical features of polycystic ovarian syndrome (POS). We studied 15 women wit POS who received Metformin 400 mg b.i.d during six months; blood levels of estradiol, testosterone (T), sexual hormone binding globulin (SHBG), insulin like growth factor-I (IGF-I) were determined. In response to treatment women exhibited decrement in serum levels of T as well as an increment, no significative, in both SHBG and IGF-I. Most of the patients showed reduction in body mass index and presented restoration of menstrual cycles. It is concluded that Metformin treatment exerts some metabolic effect which in turn induces some clinical improvement.

Authors+Show Affiliations

Unidad de Investigación de Enfermedades Endocrinas, Hospital de Especialidades del Centro Médico Nacional, Instituto Mexicano del Seguro Social, México DF.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

spa

PubMed ID

9477644

Citation

Zárate, A, et al. "[Use of Metformin in the Management of Adolescents With Polycystic Ovary Syndrome]." Ginecologia Y Obstetricia De Mexico, vol. 65, 1997, pp. 504-7.
Zárate A, Hernández M, Fonseca ME, et al. [Use of metformin in the management of adolescents with polycystic ovary syndrome]. Ginecol Obstet Mex. 1997;65:504-7.
Zárate, A., Hernández, M., Fonseca, M. E., & Ochoa, R. (1997). [Use of metformin in the management of adolescents with polycystic ovary syndrome]. Ginecologia Y Obstetricia De Mexico, 65, 504-7.
Zárate A, et al. [Use of Metformin in the Management of Adolescents With Polycystic Ovary Syndrome]. Ginecol Obstet Mex. 1997;65:504-7. PubMed PMID: 9477644.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Use of metformin in the management of adolescents with polycystic ovary syndrome]. AU - Zárate,A, AU - Hernández,M, AU - Fonseca,M E, AU - Ochoa,R, PY - 1998/3/28/pubmed PY - 1998/3/28/medline PY - 1998/3/28/entrez SP - 504 EP - 7 JF - Ginecologia y obstetricia de Mexico JO - Ginecol Obstet Mex VL - 65 N2 - Present study was designed to test that insulin resistance due to hyperinsulinism contribute to the clinical features of polycystic ovarian syndrome (POS). We studied 15 women wit POS who received Metformin 400 mg b.i.d during six months; blood levels of estradiol, testosterone (T), sexual hormone binding globulin (SHBG), insulin like growth factor-I (IGF-I) were determined. In response to treatment women exhibited decrement in serum levels of T as well as an increment, no significative, in both SHBG and IGF-I. Most of the patients showed reduction in body mass index and presented restoration of menstrual cycles. It is concluded that Metformin treatment exerts some metabolic effect which in turn induces some clinical improvement. SN - 0300-9041 UR - https://www.unboundmedicine.com/medline/citation/9477644/[Use_of_metformin_in_the_management_of_adolescents_with_polycystic_ovary_syndrome]_ L2 - https://medlineplus.gov/diabetesmedicines.html DB - PRIME DP - Unbound Medicine ER -