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[Bronchial reactivity in diabetic patients].
Rev Mal Respir. 1997 Nov; 14(5):379-85.RM

Abstract

The data of the literature concerning bronchial reactivity in diabetic patients are controversial. Therefore, we studied the influence of the presence of a diabetic cardiac autonomic neuropathy (CAN) on the ventilatory parameters measured during a methacholine-induced bronchoconstriction test. Ten insulin-dependent diabetic patients without CAN, ten insulin-dependent diabetic patients with CAN and ten healthy volunteers, all non-smokers and free of respiratory symptoms, have undergone a functional respiratory check-up before the methacholine test. The presence of CAN was classically studied by the decrease in heart rate changes during three standardized tests (deep breathing at 6 cycles/min, Valsalva manoeuver, orthostatism) which all mainly explore the parasympathetic function. The bronchial response to methacholine was similar in the healthy subjects and in the diabetic patients without CAN. However, the fall in forced expiratory volume in 1 second induced by the highest dose of methacholine was significantly less marked in the diabetic subjects with CAN than in the two other groups. These results suggest that the diabetic autonomic neuropathy also involves the vagal innervation of the respiratory tract.

Authors+Show Affiliations

Service de Diabétologie, Nutrition et Maladies métaboliques, CHU Sart Tilman, Liège, Belgique.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

fre

PubMed ID

9480482

Citation

Pieron, M, et al. "[Bronchial Reactivity in Diabetic Patients]." Revue Des Maladies Respiratoires, vol. 14, no. 5, 1997, pp. 379-85.
Pieron M, Scheen AJ, Corhay JL, et al. [Bronchial reactivity in diabetic patients]. Rev Mal Respir. 1997;14(5):379-85.
Pieron, M., Scheen, A. J., Corhay, J. L., Radermecker, M. F., & Lefebvre, P. J. (1997). [Bronchial reactivity in diabetic patients]. Revue Des Maladies Respiratoires, 14(5), 379-85.
Pieron M, et al. [Bronchial Reactivity in Diabetic Patients]. Rev Mal Respir. 1997;14(5):379-85. PubMed PMID: 9480482.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Bronchial reactivity in diabetic patients]. AU - Pieron,M, AU - Scheen,A J, AU - Corhay,J L, AU - Radermecker,M F, AU - Lefebvre,P J, PY - 1998/2/28/pubmed PY - 1998/2/28/medline PY - 1998/2/28/entrez SP - 379 EP - 85 JF - Revue des maladies respiratoires JO - Rev Mal Respir VL - 14 IS - 5 N2 - The data of the literature concerning bronchial reactivity in diabetic patients are controversial. Therefore, we studied the influence of the presence of a diabetic cardiac autonomic neuropathy (CAN) on the ventilatory parameters measured during a methacholine-induced bronchoconstriction test. Ten insulin-dependent diabetic patients without CAN, ten insulin-dependent diabetic patients with CAN and ten healthy volunteers, all non-smokers and free of respiratory symptoms, have undergone a functional respiratory check-up before the methacholine test. The presence of CAN was classically studied by the decrease in heart rate changes during three standardized tests (deep breathing at 6 cycles/min, Valsalva manoeuver, orthostatism) which all mainly explore the parasympathetic function. The bronchial response to methacholine was similar in the healthy subjects and in the diabetic patients without CAN. However, the fall in forced expiratory volume in 1 second induced by the highest dose of methacholine was significantly less marked in the diabetic subjects with CAN than in the two other groups. These results suggest that the diabetic autonomic neuropathy also involves the vagal innervation of the respiratory tract. SN - 0761-8425 UR - https://www.unboundmedicine.com/medline/citation/9480482/[Bronchial_reactivity_in_diabetic_patients]_ L2 - https://medlineplus.gov/diabeticnerveproblems.html DB - PRIME DP - Unbound Medicine ER -