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A diet rich in walnuts favourably influences plasma fatty acid profile in moderately hyperlipidaemic subjects.
Eur J Clin Nutr. 1998 Jan; 52(1):12-6.EJ

Abstract

OBJECTIVE

To compare two low fat diets one rich in walnuts on parameters of lipid metabolism in a group of hyperlipidaemic subjects.

DESIGN

A randomised cross over study.

SETTING

Department of Human Nutrition, University of Otago, Dunedin, New Zealand

SUBJECTS

Twenty one men with mean (s.d.) levels of total and LDL cholesterol of 6.58 (0.60) and 4.63 (0.58) respectively.

INTERVENTIONS

For two periods of four weeks subjects were asked to consume two low fat diets (fat 30% total energy), one containing, on average, 78 g/d walnuts. Walnuts obtained through Lincoln University and the Walnut Growers Group (South Canterbury).

RESULTS

Participants reported a higher total fat intake on the walnut diet (38% compared with 30% on the low fat diet P < 0.01) The most consistent change in fatty acid profile of triacylglycerol, phospholipid and cholesterol ester on the walnut diet was a significant (P < 0.01) increase in linoleic acid. Triacylglycerol linolenate also increased significantly (P < 0.01). Total and LDL cholesterol were lower on both experimental diets than at baseline, 0.25 mmol/l and 0.36 mmol/l respectively on the walnut diet and 0.13 mmol/l and 0.20 mmol/l respectively on the low fat diet. High density lipoprotein cholesterol was higher on both the walnut and low fat diets when compared to baseline (0.15 mmol/l and 0.12 mmol/l, respectively). When comparing the walnut and low fat diets only apo B was significantly lower (P < 0.05) on the walnut diet.

CONCLUSIONS

Despite an unintended increase in the total fat intake on the walnut diet, fatty acid profile of the major lipid fractions showed changes which might be expected to reduce risk of cardiovascular disease. The reduction of apolipoprotein B suggests a reduction in lipoprotein mediated risk, the relatively low myristic acid content of both diets perhaps explaining the absence of more extensive differences in lipoprotein levels on the two diets.

Authors+Show Affiliations

Department of Human Nutrition, University of Otago, Dunedin, New Zealand.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9481526

Citation

Chisholm, A, et al. "A Diet Rich in Walnuts Favourably Influences Plasma Fatty Acid Profile in Moderately Hyperlipidaemic Subjects." European Journal of Clinical Nutrition, vol. 52, no. 1, 1998, pp. 12-6.
Chisholm A, Mann J, Skeaff M, et al. A diet rich in walnuts favourably influences plasma fatty acid profile in moderately hyperlipidaemic subjects. Eur J Clin Nutr. 1998;52(1):12-6.
Chisholm, A., Mann, J., Skeaff, M., Frampton, C., Sutherland, W., Duncan, A., & Tiszavari, S. (1998). A diet rich in walnuts favourably influences plasma fatty acid profile in moderately hyperlipidaemic subjects. European Journal of Clinical Nutrition, 52(1), 12-6.
Chisholm A, et al. A Diet Rich in Walnuts Favourably Influences Plasma Fatty Acid Profile in Moderately Hyperlipidaemic Subjects. Eur J Clin Nutr. 1998;52(1):12-6. PubMed PMID: 9481526.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A diet rich in walnuts favourably influences plasma fatty acid profile in moderately hyperlipidaemic subjects. AU - Chisholm,A, AU - Mann,J, AU - Skeaff,M, AU - Frampton,C, AU - Sutherland,W, AU - Duncan,A, AU - Tiszavari,S, PY - 1998/3/3/pubmed PY - 1998/3/3/medline PY - 1998/3/3/entrez SP - 12 EP - 6 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 52 IS - 1 N2 - OBJECTIVE: To compare two low fat diets one rich in walnuts on parameters of lipid metabolism in a group of hyperlipidaemic subjects. DESIGN: A randomised cross over study. SETTING: Department of Human Nutrition, University of Otago, Dunedin, New Zealand SUBJECTS: Twenty one men with mean (s.d.) levels of total and LDL cholesterol of 6.58 (0.60) and 4.63 (0.58) respectively. INTERVENTIONS: For two periods of four weeks subjects were asked to consume two low fat diets (fat 30% total energy), one containing, on average, 78 g/d walnuts. Walnuts obtained through Lincoln University and the Walnut Growers Group (South Canterbury). RESULTS: Participants reported a higher total fat intake on the walnut diet (38% compared with 30% on the low fat diet P < 0.01) The most consistent change in fatty acid profile of triacylglycerol, phospholipid and cholesterol ester on the walnut diet was a significant (P < 0.01) increase in linoleic acid. Triacylglycerol linolenate also increased significantly (P < 0.01). Total and LDL cholesterol were lower on both experimental diets than at baseline, 0.25 mmol/l and 0.36 mmol/l respectively on the walnut diet and 0.13 mmol/l and 0.20 mmol/l respectively on the low fat diet. High density lipoprotein cholesterol was higher on both the walnut and low fat diets when compared to baseline (0.15 mmol/l and 0.12 mmol/l, respectively). When comparing the walnut and low fat diets only apo B was significantly lower (P < 0.05) on the walnut diet. CONCLUSIONS: Despite an unintended increase in the total fat intake on the walnut diet, fatty acid profile of the major lipid fractions showed changes which might be expected to reduce risk of cardiovascular disease. The reduction of apolipoprotein B suggests a reduction in lipoprotein mediated risk, the relatively low myristic acid content of both diets perhaps explaining the absence of more extensive differences in lipoprotein levels on the two diets. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/9481526/A_diet_rich_in_walnuts_favourably_influences_plasma_fatty_acid_profile_in_moderately_hyperlipidaemic_subjects_ L2 - https://doi.org/10.1038/sj.ejcn.1600507 DB - PRIME DP - Unbound Medicine ER -