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Gender effect on apolipoprotein E epsilon4 allele-associated risk for sporadic Alzheimer's disease.

Abstract

INTRODUCTION

The role of gender in Alzheimer's disease (AD), and its possible interaction with apolipoprotein E (apoE), has been controversial.

MATERIAL AND METHODS

ApoE allelic frequencies and the effect of apoE epsilon4 allele dosage on risk and age at onset of AD were evaluated, separately for men and women, in 100 patients with sporadic AD and 100 age-matched controls.

RESULTS

The distribution of apoE alleles and the odds ratio for AD, when associated with 1 or 2 epsilon4 alleles, were not statistically different between men and women. No effect of the dosage of the epsilon4 allele was found on the age at onset of dementia in the 2 sex groups.

CONCLUSION

Our data suggest that the relation of the apoE genotype to AD is not dependent on sex.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Service of Neurology, University Hospital Marqués de Valdecilla, Santander, Spain.

    , , , , , , ,

    Source

    Acta neurologica Scandinavica 97:1 1998 Jan pg 68-71

    MeSH

    Alleles
    Alzheimer Disease
    Apolipoprotein E4
    Apolipoproteins E
    Female
    Humans
    Male
    Prevalence
    Risk Factors
    Sex Distribution

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    9482681

    Citation

    Combarros, O, et al. "Gender Effect On Apolipoprotein E Epsilon4 Allele-associated Risk for Sporadic Alzheimer's Disease." Acta Neurologica Scandinavica, vol. 97, no. 1, 1998, pp. 68-71.
    Combarros O, Leno C, Oterino A, et al. Gender effect on apolipoprotein E epsilon4 allele-associated risk for sporadic Alzheimer's disease. Acta Neurol Scand. 1998;97(1):68-71.
    Combarros, O., Leno, C., Oterino, A., Berciano, J., Fernández-Luna, J. L., Fernández-Viadero, C., ... Delgado, M. (1998). Gender effect on apolipoprotein E epsilon4 allele-associated risk for sporadic Alzheimer's disease. Acta Neurologica Scandinavica, 97(1), pp. 68-71.
    Combarros O, et al. Gender Effect On Apolipoprotein E Epsilon4 Allele-associated Risk for Sporadic Alzheimer's Disease. Acta Neurol Scand. 1998;97(1):68-71. PubMed PMID: 9482681.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Gender effect on apolipoprotein E epsilon4 allele-associated risk for sporadic Alzheimer's disease. AU - Combarros,O, AU - Leno,C, AU - Oterino,A, AU - Berciano,J, AU - Fernández-Luna,J L, AU - Fernández-Viadero,C, AU - Peña,N, AU - Miró,J, AU - Delgado,M, PY - 1998/3/3/pubmed PY - 1998/3/3/medline PY - 1998/3/3/entrez SP - 68 EP - 71 JF - Acta neurologica Scandinavica JO - Acta Neurol. Scand. VL - 97 IS - 1 N2 - INTRODUCTION: The role of gender in Alzheimer's disease (AD), and its possible interaction with apolipoprotein E (apoE), has been controversial. MATERIAL AND METHODS: ApoE allelic frequencies and the effect of apoE epsilon4 allele dosage on risk and age at onset of AD were evaluated, separately for men and women, in 100 patients with sporadic AD and 100 age-matched controls. RESULTS: The distribution of apoE alleles and the odds ratio for AD, when associated with 1 or 2 epsilon4 alleles, were not statistically different between men and women. No effect of the dosage of the epsilon4 allele was found on the age at onset of dementia in the 2 sex groups. CONCLUSION: Our data suggest that the relation of the apoE genotype to AD is not dependent on sex. SN - 0001-6314 UR - https://www.unboundmedicine.com/medline/citation/9482681/Gender_effect_on_apolipoprotein_E_epsilon4_allele_associated_risk_for_sporadic_Alzheimer's_disease_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0001-6314&date=1998&volume=97&issue=1&spage=68 DB - PRIME DP - Unbound Medicine ER -