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Gender effect on apolipoprotein E epsilon4 allele-associated risk for sporadic Alzheimer's disease.
Acta Neurol Scand 1998; 97(1):68-71AN

Abstract

INTRODUCTION

The role of gender in Alzheimer's disease (AD), and its possible interaction with apolipoprotein E (apoE), has been controversial.

MATERIAL AND METHODS

ApoE allelic frequencies and the effect of apoE epsilon4 allele dosage on risk and age at onset of AD were evaluated, separately for men and women, in 100 patients with sporadic AD and 100 age-matched controls.

RESULTS

The distribution of apoE alleles and the odds ratio for AD, when associated with 1 or 2 epsilon4 alleles, were not statistically different between men and women. No effect of the dosage of the epsilon4 allele was found on the age at onset of dementia in the 2 sex groups.

CONCLUSION

Our data suggest that the relation of the apoE genotype to AD is not dependent on sex.

Authors+Show Affiliations

Service of Neurology, University Hospital Marqués de Valdecilla, Santander, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9482681

Citation

Combarros, O, et al. "Gender Effect On Apolipoprotein E Epsilon4 Allele-associated Risk for Sporadic Alzheimer's Disease." Acta Neurologica Scandinavica, vol. 97, no. 1, 1998, pp. 68-71.
Combarros O, Leno C, Oterino A, et al. Gender effect on apolipoprotein E epsilon4 allele-associated risk for sporadic Alzheimer's disease. Acta Neurol Scand. 1998;97(1):68-71.
Combarros, O., Leno, C., Oterino, A., Berciano, J., Fernández-Luna, J. L., Fernández-Viadero, C., ... Delgado, M. (1998). Gender effect on apolipoprotein E epsilon4 allele-associated risk for sporadic Alzheimer's disease. Acta Neurologica Scandinavica, 97(1), pp. 68-71.
Combarros O, et al. Gender Effect On Apolipoprotein E Epsilon4 Allele-associated Risk for Sporadic Alzheimer's Disease. Acta Neurol Scand. 1998;97(1):68-71. PubMed PMID: 9482681.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gender effect on apolipoprotein E epsilon4 allele-associated risk for sporadic Alzheimer's disease. AU - Combarros,O, AU - Leno,C, AU - Oterino,A, AU - Berciano,J, AU - Fernández-Luna,J L, AU - Fernández-Viadero,C, AU - Peña,N, AU - Miró,J, AU - Delgado,M, PY - 1998/3/3/pubmed PY - 1998/3/3/medline PY - 1998/3/3/entrez SP - 68 EP - 71 JF - Acta neurologica Scandinavica JO - Acta Neurol. Scand. VL - 97 IS - 1 N2 - INTRODUCTION: The role of gender in Alzheimer's disease (AD), and its possible interaction with apolipoprotein E (apoE), has been controversial. MATERIAL AND METHODS: ApoE allelic frequencies and the effect of apoE epsilon4 allele dosage on risk and age at onset of AD were evaluated, separately for men and women, in 100 patients with sporadic AD and 100 age-matched controls. RESULTS: The distribution of apoE alleles and the odds ratio for AD, when associated with 1 or 2 epsilon4 alleles, were not statistically different between men and women. No effect of the dosage of the epsilon4 allele was found on the age at onset of dementia in the 2 sex groups. CONCLUSION: Our data suggest that the relation of the apoE genotype to AD is not dependent on sex. SN - 0001-6314 UR - https://www.unboundmedicine.com/medline/citation/9482681/Gender_effect_on_apolipoprotein_E_epsilon4_allele_associated_risk_for_sporadic_Alzheimer's_disease_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0001-6314&date=1998&volume=97&issue=1&spage=68 DB - PRIME DP - Unbound Medicine ER -