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Divergent cytokine production profile in Behçet's disease. Altered Th1/Th2 cell cytokine pattern.
J Rheumatol. 1998 Feb; 25(2):329-33.JR

Abstract

OBJECTIVE

To determine Th1/Th2 cell response cytokine production profile in Behçet's disease (BD).

METHODS

Interleukin 2 (IL-2), interferon-gamma (IFN-gamma) and IL-12 (Th1 cell response), and IL-4, IL-10, and IL-13 (Th2 cell response) cytokine production from anti-CD3/anti-CD40 stimulated peripheral blood mononuclear cells (PBMC) were measured by ELISA.

RESULTS

PBMC from patients with BD produced higher levels of IL-4, IL-10, and IL-13 (Th2 cell response), almost normal levels of IL-2 (Th1 cell response), but highly deficient IFN-gamma and IL-12 (Th1 cell response). The additions of exogenous recombinant IFN-gamma to the anti-CD3 stimulated PBMC dramatically changed this pattern with enhanced IL-12 and concomitantly decreased IL-4 and IL-10 production.

CONCLUSION

The immune system in BD may be characterized by a divergent cytokine production profile of mixed Th1/Th2 (Th0) cell type; IFN-gamma is critical in modulating the IL-4, IL-10, and IL-12 cytokine network pathway in this disease.

Authors+Show Affiliations

Department of Immunology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9489829

Citation

Raziuddin, S, et al. "Divergent Cytokine Production Profile in Behçet's Disease. Altered Th1/Th2 Cell Cytokine Pattern." The Journal of Rheumatology, vol. 25, no. 2, 1998, pp. 329-33.
Raziuddin S, al-Dalaan A, Bahabri S, et al. Divergent cytokine production profile in Behçet's disease. Altered Th1/Th2 cell cytokine pattern. J Rheumatol. 1998;25(2):329-33.
Raziuddin, S., al-Dalaan, A., Bahabri, S., Siraj, A. K., & al-Sedairy, S. (1998). Divergent cytokine production profile in Behçet's disease. Altered Th1/Th2 cell cytokine pattern. The Journal of Rheumatology, 25(2), 329-33.
Raziuddin S, et al. Divergent Cytokine Production Profile in Behçet's Disease. Altered Th1/Th2 Cell Cytokine Pattern. J Rheumatol. 1998;25(2):329-33. PubMed PMID: 9489829.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Divergent cytokine production profile in Behçet's disease. Altered Th1/Th2 cell cytokine pattern. AU - Raziuddin,S, AU - al-Dalaan,A, AU - Bahabri,S, AU - Siraj,A K, AU - al-Sedairy,S, PY - 1998/3/7/pubmed PY - 1998/3/7/medline PY - 1998/3/7/entrez SP - 329 EP - 33 JF - The Journal of rheumatology JO - J Rheumatol VL - 25 IS - 2 N2 - OBJECTIVE: To determine Th1/Th2 cell response cytokine production profile in Behçet's disease (BD). METHODS: Interleukin 2 (IL-2), interferon-gamma (IFN-gamma) and IL-12 (Th1 cell response), and IL-4, IL-10, and IL-13 (Th2 cell response) cytokine production from anti-CD3/anti-CD40 stimulated peripheral blood mononuclear cells (PBMC) were measured by ELISA. RESULTS: PBMC from patients with BD produced higher levels of IL-4, IL-10, and IL-13 (Th2 cell response), almost normal levels of IL-2 (Th1 cell response), but highly deficient IFN-gamma and IL-12 (Th1 cell response). The additions of exogenous recombinant IFN-gamma to the anti-CD3 stimulated PBMC dramatically changed this pattern with enhanced IL-12 and concomitantly decreased IL-4 and IL-10 production. CONCLUSION: The immune system in BD may be characterized by a divergent cytokine production profile of mixed Th1/Th2 (Th0) cell type; IFN-gamma is critical in modulating the IL-4, IL-10, and IL-12 cytokine network pathway in this disease. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/9489829/Divergent_cytokine_production_profile_in_Behçet's_disease__Altered_Th1/Th2_cell_cytokine_pattern_ L2 - http://www.diseaseinfosearch.org/result/780 DB - PRIME DP - Unbound Medicine ER -