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The risk of gastric carcinoma and carcinoid tumours in patients with pernicious anaemia. A prospective follow-up study.
Scand J Gastroenterol 1998; 33(1):88-92SJ

Abstract

BACKGROUND

This endoscopic follow-up study was undertaken to evaluate the risk of gastric cancer (GC) and carcinoids in patients with pernicious anaemia (PA) and to analyse whether early detection of GC could be provided by regular endoscopic follow-up.

METHODS

Screening gastroscopy was performed in 71 patients with pernicious anaemia, and thereafter they were followed up with gastroscopies at 3-year intervals for a mean time of 5.8 years. Standardized incidence ratios (SIR) were calculated, the expected number being based on incidence rates in the whole Finnish population.

RESULTS

Two GCs were found during the follow-up period; one of these patients was asymptomatic and the other had abdominal symptoms. The SIR was 5.0 (95% confidence interval, 0.6-18). Eight carcinoids were detected, and all but one were removed endoscopically, and no metastases were found. The patients who had carcinoid tumours were younger at the diagnosis of PA than those who did not develop carcinoids (mean, 40 versus 55 years). Additionally, the patients with carcinoids had longer duration of PA (mean, 11 versus 5 years).

CONCLUSIONS

During the follow-up period the risk of GC was increased. The risk of gastric carcinoids seems to be very high in patients with pernicious anaemia when compared with a normal population, but they are mostly relatively benign tumours. Regular routine gastroscopic follow-up is not indicated in patients with pernicious anaemia.

Authors+Show Affiliations

Second Dept. of Surgery, Helsinki University Central Hospital, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9489914

Citation

Kokkola, A, et al. "The Risk of Gastric Carcinoma and Carcinoid Tumours in Patients With Pernicious Anaemia. a Prospective Follow-up Study." Scandinavian Journal of Gastroenterology, vol. 33, no. 1, 1998, pp. 88-92.
Kokkola A, Sjöblom SM, Haapiainen R, et al. The risk of gastric carcinoma and carcinoid tumours in patients with pernicious anaemia. A prospective follow-up study. Scand J Gastroenterol. 1998;33(1):88-92.
Kokkola, A., Sjöblom, S. M., Haapiainen, R., Sipponen, P., Puolakkainen, P., & Järvinen, H. (1998). The risk of gastric carcinoma and carcinoid tumours in patients with pernicious anaemia. A prospective follow-up study. Scandinavian Journal of Gastroenterology, 33(1), pp. 88-92.
Kokkola A, et al. The Risk of Gastric Carcinoma and Carcinoid Tumours in Patients With Pernicious Anaemia. a Prospective Follow-up Study. Scand J Gastroenterol. 1998;33(1):88-92. PubMed PMID: 9489914.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The risk of gastric carcinoma and carcinoid tumours in patients with pernicious anaemia. A prospective follow-up study. AU - Kokkola,A, AU - Sjöblom,S M, AU - Haapiainen,R, AU - Sipponen,P, AU - Puolakkainen,P, AU - Järvinen,H, PY - 1998/3/7/pubmed PY - 1998/3/7/medline PY - 1998/3/7/entrez SP - 88 EP - 92 JF - Scandinavian journal of gastroenterology JO - Scand. J. Gastroenterol. VL - 33 IS - 1 N2 - BACKGROUND: This endoscopic follow-up study was undertaken to evaluate the risk of gastric cancer (GC) and carcinoids in patients with pernicious anaemia (PA) and to analyse whether early detection of GC could be provided by regular endoscopic follow-up. METHODS: Screening gastroscopy was performed in 71 patients with pernicious anaemia, and thereafter they were followed up with gastroscopies at 3-year intervals for a mean time of 5.8 years. Standardized incidence ratios (SIR) were calculated, the expected number being based on incidence rates in the whole Finnish population. RESULTS: Two GCs were found during the follow-up period; one of these patients was asymptomatic and the other had abdominal symptoms. The SIR was 5.0 (95% confidence interval, 0.6-18). Eight carcinoids were detected, and all but one were removed endoscopically, and no metastases were found. The patients who had carcinoid tumours were younger at the diagnosis of PA than those who did not develop carcinoids (mean, 40 versus 55 years). Additionally, the patients with carcinoids had longer duration of PA (mean, 11 versus 5 years). CONCLUSIONS: During the follow-up period the risk of GC was increased. The risk of gastric carcinoids seems to be very high in patients with pernicious anaemia when compared with a normal population, but they are mostly relatively benign tumours. Regular routine gastroscopic follow-up is not indicated in patients with pernicious anaemia. SN - 0036-5521 UR - https://www.unboundmedicine.com/medline/citation/9489914/The_risk_of_gastric_carcinoma_and_carcinoid_tumours_in_patients_with_pernicious_anaemia__A_prospective_follow_up_study_ L2 - http://www.tandfonline.com/doi/full/10.1080/00365529850166266 DB - PRIME DP - Unbound Medicine ER -