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Inositol trisphosphate mediates a RAS-independent response to LET-23 receptor tyrosine kinase activation in C. elegans.
Cell. 1998 Feb 20; 92(4):523-33.Cell

Abstract

Activity of LET-23, the C. elegans homolog of the epidermal growth factor receptor, is required in multiple tissues. RAS activation is necessary and sufficient for certain LET-23 functions. We show that an inositol trisphosphate receptor can act as a RAS-independent, tissue-specific positive effector of LET-23. Moreover, an inositol trisphosphate kinase negatively regulates this transduction pathway. Signals transduced by LET-23 control ovulation through changes in spermathecal dilation, possibly dependent upon calcium release regulated by both IP3 and IP4. Our results demonstrate that one mechanism by which receptor tyrosine kinases can evoke tissue-specific responses is through activation of distinct signal transduction cascades in different tissues.

Authors+Show Affiliations

Howard Hughes Medical Institute and Division of Biology, California Institute of Technology, Pasadena 91125, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9491893

Citation

Clandinin, T R., et al. "Inositol Trisphosphate Mediates a RAS-independent Response to LET-23 Receptor Tyrosine Kinase Activation in C. Elegans." Cell, vol. 92, no. 4, 1998, pp. 523-33.
Clandinin TR, DeModena JA, Sternberg PW. Inositol trisphosphate mediates a RAS-independent response to LET-23 receptor tyrosine kinase activation in C. elegans. Cell. 1998;92(4):523-33.
Clandinin, T. R., DeModena, J. A., & Sternberg, P. W. (1998). Inositol trisphosphate mediates a RAS-independent response to LET-23 receptor tyrosine kinase activation in C. elegans. Cell, 92(4), 523-33.
Clandinin TR, DeModena JA, Sternberg PW. Inositol Trisphosphate Mediates a RAS-independent Response to LET-23 Receptor Tyrosine Kinase Activation in C. Elegans. Cell. 1998 Feb 20;92(4):523-33. PubMed PMID: 9491893.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inositol trisphosphate mediates a RAS-independent response to LET-23 receptor tyrosine kinase activation in C. elegans. AU - Clandinin,T R, AU - DeModena,J A, AU - Sternberg,P W, PY - 1998/3/10/pubmed PY - 1998/3/10/medline PY - 1998/3/10/entrez SP - 523 EP - 33 JF - Cell JO - Cell VL - 92 IS - 4 N2 - Activity of LET-23, the C. elegans homolog of the epidermal growth factor receptor, is required in multiple tissues. RAS activation is necessary and sufficient for certain LET-23 functions. We show that an inositol trisphosphate receptor can act as a RAS-independent, tissue-specific positive effector of LET-23. Moreover, an inositol trisphosphate kinase negatively regulates this transduction pathway. Signals transduced by LET-23 control ovulation through changes in spermathecal dilation, possibly dependent upon calcium release regulated by both IP3 and IP4. Our results demonstrate that one mechanism by which receptor tyrosine kinases can evoke tissue-specific responses is through activation of distinct signal transduction cascades in different tissues. SN - 0092-8674 UR - https://www.unboundmedicine.com/medline/citation/9491893/Inositol_trisphosphate_mediates_a_RAS_independent_response_to_LET_23_receptor_tyrosine_kinase_activation_in_C__elegans_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0092-8674(00)80945-9 DB - PRIME DP - Unbound Medicine ER -