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Effect of endotoxin on hormonal responses to thyrotropin and thyrotropin-releasing hormone in dogs.
Am J Vet Res. 1998 Feb; 59(2):186-91.AJ

Abstract

OBJECTIVE

To determine whether administration of endotoxin affects thyroid gland function in dogs.

ANIMALS

24 Beagles.

PROCEDURE

Dogs were given thyrotropin (TSH) or thyrotropin-releasing hormone (TRH) on 2 occasions. Twenty-four hours before the second challenge with TSH or TRH, all dogs were given 5 micrograms of endotoxin/kg of body weight. Serum concentrations of thyroxine (T4), free T4 (fT4), 3,3',5-triiodothyronine (T3), reverse T3, autoantibodies to T3, and plasma concentrations of ACTH and cortisol were determined.

RESULTS

Treatment with endotoxin was associated with reduced baseline concentration of serum T3 and increased baseline concentration of reverse T3 and free T4. Endotoxin treatment resulted in reduced peak serum concentration of T4 after TSH and TRH. However, peak serum concentration of fT4 after TSH and TRH were not affected by endotoxin.

CONCLUSIONS

A single dose of endotoxin affects several aspects of thyroid gland function in dogs, including T4 binding, deiodinase activity, and the thyroidal response to TSH and TRH.

CLINICAL RELEVANCE

Acute or chronic nonthyroidal illness may affect thyroid gland function in dogs. Determination of fT4 concentration may provide a means of differentiating the effects of nonthyroidal illness from those of thyroid dysfunction, because endotoxin treatment was associated with increased baseline serum free T4 concentration and unchanged peak serum fT4 concentration after administration of TSH or TRH.

Authors+Show Affiliations

Yu AA
Department of Small Animal Surgery and Medicine, Auburn University College of Veterinary Medicine, AL 36849, USA.
Kemppainen RJ
No affiliation info available
MacDonald JM
No affiliation info available

MeSH

Adrenocorticotropic HormoneAnimalsDogsEndotoxinsFemaleHydrocortisoneMaleRegression AnalysisThyroid GlandThyrotropinThyrotropin-Releasing HormoneThyroxineTime FactorsTriiodothyronineTriiodothyronine, Reverse

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9492934

Citation

Yu, A A., et al. "Effect of Endotoxin On Hormonal Responses to Thyrotropin and Thyrotropin-releasing Hormone in Dogs." American Journal of Veterinary Research, vol. 59, no. 2, 1998, pp. 186-91.
Yu AA, Kemppainen RJ, MacDonald JM. Effect of endotoxin on hormonal responses to thyrotropin and thyrotropin-releasing hormone in dogs. Am J Vet Res. 1998;59(2):186-91.
Yu, A. A., Kemppainen, R. J., & MacDonald, J. M. (1998). Effect of endotoxin on hormonal responses to thyrotropin and thyrotropin-releasing hormone in dogs. American Journal of Veterinary Research, 59(2), 186-91.
Yu AA, Kemppainen RJ, MacDonald JM. Effect of Endotoxin On Hormonal Responses to Thyrotropin and Thyrotropin-releasing Hormone in Dogs. Am J Vet Res. 1998;59(2):186-91. PubMed PMID: 9492934.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of endotoxin on hormonal responses to thyrotropin and thyrotropin-releasing hormone in dogs. AU - Yu,A A, AU - Kemppainen,R J, AU - MacDonald,J M, PY - 1998/3/11/pubmed PY - 1998/3/11/medline PY - 1998/3/11/entrez SP - 186 EP - 91 JF - American journal of veterinary research JO - Am J Vet Res VL - 59 IS - 2 N2 - OBJECTIVE: To determine whether administration of endotoxin affects thyroid gland function in dogs. ANIMALS: 24 Beagles. PROCEDURE: Dogs were given thyrotropin (TSH) or thyrotropin-releasing hormone (TRH) on 2 occasions. Twenty-four hours before the second challenge with TSH or TRH, all dogs were given 5 micrograms of endotoxin/kg of body weight. Serum concentrations of thyroxine (T4), free T4 (fT4), 3,3',5-triiodothyronine (T3), reverse T3, autoantibodies to T3, and plasma concentrations of ACTH and cortisol were determined. RESULTS: Treatment with endotoxin was associated with reduced baseline concentration of serum T3 and increased baseline concentration of reverse T3 and free T4. Endotoxin treatment resulted in reduced peak serum concentration of T4 after TSH and TRH. However, peak serum concentration of fT4 after TSH and TRH were not affected by endotoxin. CONCLUSIONS: A single dose of endotoxin affects several aspects of thyroid gland function in dogs, including T4 binding, deiodinase activity, and the thyroidal response to TSH and TRH. CLINICAL RELEVANCE: Acute or chronic nonthyroidal illness may affect thyroid gland function in dogs. Determination of fT4 concentration may provide a means of differentiating the effects of nonthyroidal illness from those of thyroid dysfunction, because endotoxin treatment was associated with increased baseline serum free T4 concentration and unchanged peak serum fT4 concentration after administration of TSH or TRH. SN - 0002-9645 UR - https://www.unboundmedicine.com/medline/citation/9492934/Effect_of_endotoxin_on_hormonal_responses_to_thyrotropin_and_thyrotropin_releasing_hormone_in_dogs_ DB - PRIME DP - Unbound Medicine ER -