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The role of CD4+ and CD8+ T-cells in host morbidity and innate resistance to angiostrongylus cantonensis in the mouse.
Parasitol Res. 1998; 84(2):91-9.PR

Abstract

Strain-dependent differences in host morbidity and mortality due to Angiostrongylus cantonensis infection have been established between C57BL/6 and BALB/c mice; C57BL/6 mice show rapid worm killing with low morbidity, whereas BALB/c mice indicate slow worm killing with high morbidity and mortality. To determine the possible roles of CD4+ and CD8+ T-cells in host morbidity and innate resistance to A. cantonensis infection we treated C57BL/6 and BALB/c mice with anti-CD4 or anti-CD8 monoclonal antibody and examined the changes in host morbidity and worm-killing activity. Our study indicates that anti-CD4 antibody treatment interferes with worm killing and improves the morbidity of A. cantonensis-infected BALB/c mice, whereas anti-CD8 antibody treatment fails to improve the morbidity. Tumor necrosis factor-alpha (TNF-alpha, or cachectin) production in infected mice was not correlated with host morbidity. Anti-IL-5 monoclonal antibody treatment also failed to affect the morbidity of infected BALB/c mice, although their worm-killing activity was restrained as shown in anti-CD4-treated mice. These findings clearly indicate that the morbidity of infected BALB/c mice is regulated by some unknown CD4+ T-cell-dependent mechanism but not by an IL-5-, eosinophil-, or TNF-alpha-dependent mechanism.

Authors+Show Affiliations

Department of Parasitology, Akita University, School of Medicine, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9493206

Citation

Aoki, M, et al. "The Role of CD4+ and CD8+ T-cells in Host Morbidity and Innate Resistance to Angiostrongylus Cantonensis in the Mouse." Parasitology Research, vol. 84, no. 2, 1998, pp. 91-9.
Aoki M, Sugaya H, Ishida K, et al. The role of CD4+ and CD8+ T-cells in host morbidity and innate resistance to angiostrongylus cantonensis in the mouse. Parasitol Res. 1998;84(2):91-9.
Aoki, M., Sugaya, H., Ishida, K., & Yoshimura, K. (1998). The role of CD4+ and CD8+ T-cells in host morbidity and innate resistance to angiostrongylus cantonensis in the mouse. Parasitology Research, 84(2), 91-9.
Aoki M, et al. The Role of CD4+ and CD8+ T-cells in Host Morbidity and Innate Resistance to Angiostrongylus Cantonensis in the Mouse. Parasitol Res. 1998;84(2):91-9. PubMed PMID: 9493206.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of CD4+ and CD8+ T-cells in host morbidity and innate resistance to angiostrongylus cantonensis in the mouse. AU - Aoki,M, AU - Sugaya,H, AU - Ishida,K, AU - Yoshimura,K, PY - 1998/3/11/pubmed PY - 1998/3/11/medline PY - 1998/3/11/entrez SP - 91 EP - 9 JF - Parasitology research JO - Parasitol Res VL - 84 IS - 2 N2 - Strain-dependent differences in host morbidity and mortality due to Angiostrongylus cantonensis infection have been established between C57BL/6 and BALB/c mice; C57BL/6 mice show rapid worm killing with low morbidity, whereas BALB/c mice indicate slow worm killing with high morbidity and mortality. To determine the possible roles of CD4+ and CD8+ T-cells in host morbidity and innate resistance to A. cantonensis infection we treated C57BL/6 and BALB/c mice with anti-CD4 or anti-CD8 monoclonal antibody and examined the changes in host morbidity and worm-killing activity. Our study indicates that anti-CD4 antibody treatment interferes with worm killing and improves the morbidity of A. cantonensis-infected BALB/c mice, whereas anti-CD8 antibody treatment fails to improve the morbidity. Tumor necrosis factor-alpha (TNF-alpha, or cachectin) production in infected mice was not correlated with host morbidity. Anti-IL-5 monoclonal antibody treatment also failed to affect the morbidity of infected BALB/c mice, although their worm-killing activity was restrained as shown in anti-CD4-treated mice. These findings clearly indicate that the morbidity of infected BALB/c mice is regulated by some unknown CD4+ T-cell-dependent mechanism but not by an IL-5-, eosinophil-, or TNF-alpha-dependent mechanism. SN - 0932-0113 UR - https://www.unboundmedicine.com/medline/citation/9493206/The_role_of_CD4+_and_CD8+_T_cells_in_host_morbidity_and_innate_resistance_to_angiostrongylus_cantonensis_in_the_mouse_ L2 - https://dx.doi.org/10.1007/s004360050363 DB - PRIME DP - Unbound Medicine ER -