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Analysis of flavonoids in tablets and urine by gas chromatography/mass spectrometry and liquid chromatography/mass spectrometry.
Rapid Commun Mass Spectrom. 1998; 12(4):153-6.RC

Abstract

A method was developed for the analysis and characterization of quercetin and kaempferol in urine following ingestion of Ginkgo biloba tablets. The method utilized gas chromatography/negative ion chemical ionization mass spectrometry of the trimethysilyl derivatives of the flavonoids. Limits of detection for these compounds using this method were ca. 20 pg on column. Liquid chromatography with electrospray mass spectrometry in the negative ion mode was utilized to characterize the complex mixture of glycosides present in the G. biloba tablets, the limit of detection with this technique was ca. 10 ng on column.

Authors+Show Affiliations

Watson DG
Department of Pharmaceutical Sciences, University of Strathclyde, Glasgow, UK.
Pitt AR
No affiliation info available

MeSH

Chromatography, High Pressure LiquidFlavonoidsGas Chromatography-Mass SpectrometryHumansHydrolysisKaempferolsPlants, MedicinalQuercetinTablets

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

9493410

Citation

Watson, D G., and A R. Pitt. "Analysis of Flavonoids in Tablets and Urine By Gas Chromatography/mass Spectrometry and Liquid Chromatography/mass Spectrometry." Rapid Communications in Mass Spectrometry : RCM, vol. 12, no. 4, 1998, pp. 153-6.
Watson DG, Pitt AR. Analysis of flavonoids in tablets and urine by gas chromatography/mass spectrometry and liquid chromatography/mass spectrometry. Rapid Commun Mass Spectrom. 1998;12(4):153-6.
Watson, D. G., & Pitt, A. R. (1998). Analysis of flavonoids in tablets and urine by gas chromatography/mass spectrometry and liquid chromatography/mass spectrometry. Rapid Communications in Mass Spectrometry : RCM, 12(4), 153-6.
Watson DG, Pitt AR. Analysis of Flavonoids in Tablets and Urine By Gas Chromatography/mass Spectrometry and Liquid Chromatography/mass Spectrometry. Rapid Commun Mass Spectrom. 1998;12(4):153-6. PubMed PMID: 9493410.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analysis of flavonoids in tablets and urine by gas chromatography/mass spectrometry and liquid chromatography/mass spectrometry. AU - Watson,D G, AU - Pitt,A R, PY - 1998/3/11/pubmed PY - 1998/3/11/medline PY - 1998/3/11/entrez SP - 153 EP - 6 JF - Rapid communications in mass spectrometry : RCM JO - Rapid Commun Mass Spectrom VL - 12 IS - 4 N2 - A method was developed for the analysis and characterization of quercetin and kaempferol in urine following ingestion of Ginkgo biloba tablets. The method utilized gas chromatography/negative ion chemical ionization mass spectrometry of the trimethysilyl derivatives of the flavonoids. Limits of detection for these compounds using this method were ca. 20 pg on column. Liquid chromatography with electrospray mass spectrometry in the negative ion mode was utilized to characterize the complex mixture of glycosides present in the G. biloba tablets, the limit of detection with this technique was ca. 10 ng on column. SN - 0951-4198 UR - https://www.unboundmedicine.com/medline/citation/9493410/Analysis_of_flavonoids_in_tablets_and_urine_by_gas_chromatography/mass_spectrometry_and_liquid_chromatography/mass_spectrometry_ L2 - https://doi.org/10.1002/(SICI)1097-0231(19980227)12:4<153::AID-RCM122>3.0.CO;2-4 DB - PRIME DP - Unbound Medicine ER -