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Cromolyn sodium prevents bronchoconstriction and urinary LTE4 excretion in aspirin-induced asthma.
Ann Allergy Asthma Immunol. 1998 Feb; 80(2):171-6.AA

Abstract

BACKGROUND

Inhalation of cromolyn sodium protects against sulpyrine-induced bronchoconstriction and prevents urinary leukotriene E4 (u-LTE4) excretion in aspirin-induced asthma.

OBJECTIVE

This study was designed to investigate the protective effect of cromolyn sodium on airway responsiveness to the sulpyrine provocation test, and to investigate whether this protective activity is associated with a reduction in aspirin-induced urinary excretion of LTE4, a marker of the cysteinyl leukotriene overproduction that participates in the pathogenesis of aspirin-induced asthma.

METHODS

We evaluated the effects of pretreatment with cromolyn sodium on bronchoconstriction precipitated by inhalation of sulpyrine in ten adult patients with mild aspirin-induced asthma. Those who were in stable clinical condition and were hyperresponsive to sulpyrine provocation test were allocated to this study. Urinary leukotriene E4 was measured using combined reverse phase high performance liquid chromatography (rp-HPLC)/enzyme immunoassay.

RESULTS

Inhaled cromolyn sodium protects against aspirin-induced attacks of asthma through mechanisms not related to the bronchodilator property, but related to the improvement of the bronchial hypersensitivity, almost completely in all patients (P < .001). By contrast, after cromolyn sodium the maximum level of u-LTE4 was significantly lower than control (P < .05).

CONCLUSION

Our results suggest for the first time that inhaled cromolyn sodium is one of the most useful inhibitors of aspirin-induced bronchoconstriction, probably acting by inhibiting the release of cysteinyl leukotrienes, and possibly other chemical mediators, by bronchial inflammatory cells.

Authors+Show Affiliations

Department of Internal Medicine, AOKI International Medical Center, Yokohama, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9494450

Citation

Yoshida, S, et al. "Cromolyn Sodium Prevents Bronchoconstriction and Urinary LTE4 Excretion in Aspirin-induced Asthma." Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, vol. 80, no. 2, 1998, pp. 171-6.
Yoshida S, Amayasu H, Sakamoto H, et al. Cromolyn sodium prevents bronchoconstriction and urinary LTE4 excretion in aspirin-induced asthma. Ann Allergy Asthma Immunol. 1998;80(2):171-6.
Yoshida, S., Amayasu, H., Sakamoto, H., Onuma, K., Shoji, T., Nakagawa, H., & Tajima, T. (1998). Cromolyn sodium prevents bronchoconstriction and urinary LTE4 excretion in aspirin-induced asthma. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, 80(2), 171-6.
Yoshida S, et al. Cromolyn Sodium Prevents Bronchoconstriction and Urinary LTE4 Excretion in Aspirin-induced Asthma. Ann Allergy Asthma Immunol. 1998;80(2):171-6. PubMed PMID: 9494450.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cromolyn sodium prevents bronchoconstriction and urinary LTE4 excretion in aspirin-induced asthma. AU - Yoshida,S, AU - Amayasu,H, AU - Sakamoto,H, AU - Onuma,K, AU - Shoji,T, AU - Nakagawa,H, AU - Tajima,T, PY - 1998/3/12/pubmed PY - 1998/3/12/medline PY - 1998/3/12/entrez SP - 171 EP - 6 JF - Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology JO - Ann Allergy Asthma Immunol VL - 80 IS - 2 N2 - BACKGROUND: Inhalation of cromolyn sodium protects against sulpyrine-induced bronchoconstriction and prevents urinary leukotriene E4 (u-LTE4) excretion in aspirin-induced asthma. OBJECTIVE: This study was designed to investigate the protective effect of cromolyn sodium on airway responsiveness to the sulpyrine provocation test, and to investigate whether this protective activity is associated with a reduction in aspirin-induced urinary excretion of LTE4, a marker of the cysteinyl leukotriene overproduction that participates in the pathogenesis of aspirin-induced asthma. METHODS: We evaluated the effects of pretreatment with cromolyn sodium on bronchoconstriction precipitated by inhalation of sulpyrine in ten adult patients with mild aspirin-induced asthma. Those who were in stable clinical condition and were hyperresponsive to sulpyrine provocation test were allocated to this study. Urinary leukotriene E4 was measured using combined reverse phase high performance liquid chromatography (rp-HPLC)/enzyme immunoassay. RESULTS: Inhaled cromolyn sodium protects against aspirin-induced attacks of asthma through mechanisms not related to the bronchodilator property, but related to the improvement of the bronchial hypersensitivity, almost completely in all patients (P < .001). By contrast, after cromolyn sodium the maximum level of u-LTE4 was significantly lower than control (P < .05). CONCLUSION: Our results suggest for the first time that inhaled cromolyn sodium is one of the most useful inhibitors of aspirin-induced bronchoconstriction, probably acting by inhibiting the release of cysteinyl leukotrienes, and possibly other chemical mediators, by bronchial inflammatory cells. SN - 1081-1206 UR - https://www.unboundmedicine.com/medline/citation/9494450/Cromolyn_sodium_prevents_bronchoconstriction_and_urinary_LTE4_excretion_in_aspirin_induced_asthma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1081-1206(10)62951-1 DB - PRIME DP - Unbound Medicine ER -