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Anti-CagA antibodies are associated with atrophic gastritis in a population at high gastric cancer risk: a morphometric study by computerized image analysis.
Ital J Gastroenterol Hepatol. 1997 Oct; 29(5):409-14.IJ

Abstract

BACKGROUND

CagA-positive Helicobacter pylori strains appear to increase the risk for atrophic gastritis.

AIM

To verify the association between CagA status and atrophic gastritis in the general population by means of computerized image analysis.

SUBJECTS

Forty-five subjects were chosen out of a representative sample of a population at high gastric cancer risk.

METHODS

Helicobacter pylori status was assessed by IgG ELISA, rapid urease test and histology. Serum anti-CagA antibodies were detected by western blotting. Subjects were subdivided into 3 groups: 15 subjects Helicobacter pylori positive CagA-positive, 15 Helicobacter pylori positive CagA-negative and 15 controls Helicobacter pylori negative. Biopsies were studied using the Sydney System score. A computerized image analysis was used to count inflammatory cells in the lamina propria and to measure the area of the gastric glands.

RESULTS

Anti-CagA antibodies were associated with reduction of gland area (126,671 +/- 81,032 mu 2/mm2 vs 231,384 +/- 54,159; p = 0.0001), with increasing both of polymorphonuclear cells (426 +/- 238 cell/mm2 vs 136 +/- 69; p = 0.0001) and mononuclear cells (8675 +/- 1304 cell/mm2 vs 7141 +/- 1230; p = 0.003).

CONCLUSIONS

The association of anti-CagA antibodies with a high grade of gastric atrophy further supports the hypothesis that Helicobacter pylori CagA-positive strains can promote the multifactorial process of gastric carcinogenesis.

Authors+Show Affiliations

Bonvicini F
Department of Internal Medicine, University of Bologna, Italy.
Baldini L
No affiliation info available
Pretolani S
No affiliation info available
Figura N
No affiliation info available
Epifanio G
No affiliation info available
Armuzzi A
No affiliation info available
Miglio F
No affiliation info available
Gasbarrini G
No affiliation info available

MeSH

AdultAgedAntibodies, BacterialAntigens, BacterialBacterial ProteinsFemaleGastric MucosaGastritis, AtrophicHelicobacter pyloriHumansImage Processing, Computer-AssistedMaleMiddle AgedRisk FactorsStomach Neoplasms

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9494848

Citation

Bonvicini, F, et al. "Anti-CagA Antibodies Are Associated With Atrophic Gastritis in a Population at High Gastric Cancer Risk: a Morphometric Study By Computerized Image Analysis." Italian Journal of Gastroenterology and Hepatology, vol. 29, no. 5, 1997, pp. 409-14.
Bonvicini F, Baldini L, Pretolani S, et al. Anti-CagA antibodies are associated with atrophic gastritis in a population at high gastric cancer risk: a morphometric study by computerized image analysis. Ital J Gastroenterol Hepatol. 1997;29(5):409-14.
Bonvicini, F., Baldini, L., Pretolani, S., Figura, N., Epifanio, G., Armuzzi, A., Miglio, F., & Gasbarrini, G. (1997). Anti-CagA antibodies are associated with atrophic gastritis in a population at high gastric cancer risk: a morphometric study by computerized image analysis. Italian Journal of Gastroenterology and Hepatology, 29(5), 409-14.
Bonvicini F, et al. Anti-CagA Antibodies Are Associated With Atrophic Gastritis in a Population at High Gastric Cancer Risk: a Morphometric Study By Computerized Image Analysis. Ital J Gastroenterol Hepatol. 1997;29(5):409-14. PubMed PMID: 9494848.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-CagA antibodies are associated with atrophic gastritis in a population at high gastric cancer risk: a morphometric study by computerized image analysis. AU - Bonvicini,F, AU - Baldini,L, AU - Pretolani,S, AU - Figura,N, AU - Epifanio,G, AU - Armuzzi,A, AU - Miglio,F, AU - Gasbarrini,G, PY - 1998/3/12/pubmed PY - 1998/3/12/medline PY - 1998/3/12/entrez SP - 409 EP - 14 JF - Italian journal of gastroenterology and hepatology JO - Ital J Gastroenterol Hepatol VL - 29 IS - 5 N2 - BACKGROUND: CagA-positive Helicobacter pylori strains appear to increase the risk for atrophic gastritis. AIM: To verify the association between CagA status and atrophic gastritis in the general population by means of computerized image analysis. SUBJECTS: Forty-five subjects were chosen out of a representative sample of a population at high gastric cancer risk. METHODS: Helicobacter pylori status was assessed by IgG ELISA, rapid urease test and histology. Serum anti-CagA antibodies were detected by western blotting. Subjects were subdivided into 3 groups: 15 subjects Helicobacter pylori positive CagA-positive, 15 Helicobacter pylori positive CagA-negative and 15 controls Helicobacter pylori negative. Biopsies were studied using the Sydney System score. A computerized image analysis was used to count inflammatory cells in the lamina propria and to measure the area of the gastric glands. RESULTS: Anti-CagA antibodies were associated with reduction of gland area (126,671 +/- 81,032 mu 2/mm2 vs 231,384 +/- 54,159; p = 0.0001), with increasing both of polymorphonuclear cells (426 +/- 238 cell/mm2 vs 136 +/- 69; p = 0.0001) and mononuclear cells (8675 +/- 1304 cell/mm2 vs 7141 +/- 1230; p = 0.003). CONCLUSIONS: The association of anti-CagA antibodies with a high grade of gastric atrophy further supports the hypothesis that Helicobacter pylori CagA-positive strains can promote the multifactorial process of gastric carcinogenesis. SN - 1125-8055 UR - https://www.unboundmedicine.com/medline/citation/9494848/Anti_CagA_antibodies_are_associated_with_atrophic_gastritis_in_a_population_at_high_gastric_cancer_risk:_a_morphometric_study_by_computerized_image_analysis_ L2 - https://medlineplus.gov/stomachcancer.html DB - PRIME DP - Unbound Medicine ER -