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Interaction of blood lead and delta-aminolevulinic acid dehydratase genotype on markers of heme synthesis and sperm production in lead smelter workers.
Environ Health Perspect. 1998 Apr; 106(4):213-6.EH

Abstract

The gene that encodes gamma-aminolevulinic acid dehydratase (ALAD) has a polymorphism that may modify lead toxicokinetics and ultimately influence individual susceptibility to lead poisoning. To evaluate the effect of the ALAD polymorphism on lead-mediated outcomes, a cross-sectional study of male employees from a lead-zinc smelter compared associations between blood lead concentration and markers of heme synthesis and semen quality with respect to ALAD genotype. Male employees were recruited via postal questionnaire to donate blood and urine for analysis of blood lead, zinc protoporphyrin (ZPP), urinary coproporphyrin (CPU), and ALAD genotype, and semen samples for semen analysis. Of the 134 workers who had ALAD genotypes completed, 114 (85%) were ALAD1-1 (ALAD1) and 20 (15%) were ALAD1-2 (ALAD2). The mean blood lead concentrations for ALAD1 and ALAD2 were 23.1 and 28.4 microg/dl (p = 0.08), respectively. ZPP/heme ratios were higher in ALAD1 workers (68.6 vs. 57.8 micromol/ml; p = 0.14), and the slope of the blood lead ZPP linear relationship was greater for ALAD1 (2.83 vs. 1.50, p = 0.06). No linear relationship between CPU and blood lead concentration was observed for either ALAD1 or ALAD2. The associations of blood lead concentration with ZPP, CPU, sperm count, and sperm concentration were more evident in workers with the ALAD1 genotype and blood lead concentrations >/= 40 microg/dl. The ALAD genetic polymorphism appears to modify the association between blood lead concentration and ZPP. However, consistent modification of effects were not found for CPU, sperm count, or sperm concentration.

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Authors+Show Affiliations

Alexander BH
Department of Environmental Health, University of Washington, Seattle, WA 98195, USA.
Checkoway H
No affiliation info available
Costa-Mallen P
No affiliation info available
Faustman EM
No affiliation info available
Woods JS
No affiliation info available
Kelsey KT
No affiliation info available
van Netten C
No affiliation info available
Costa LG
No affiliation info available

MeSH

AdultCoproporphyrinsCross-Sectional StudiesGenotypeHemeHumansLeadMaleMetallurgyOccupational ExposurePorphobilinogen SynthaseProtoporphyrinsSemenSperm CountSpermatogenesis

Pub Type(s)

Clinical Trial
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9495797

Citation

Alexander, B H., et al. "Interaction of Blood Lead and Delta-aminolevulinic Acid Dehydratase Genotype On Markers of Heme Synthesis and Sperm Production in Lead Smelter Workers." Environmental Health Perspectives, vol. 106, no. 4, 1998, pp. 213-6.
Alexander BH, Checkoway H, Costa-Mallen P, et al. Interaction of blood lead and delta-aminolevulinic acid dehydratase genotype on markers of heme synthesis and sperm production in lead smelter workers. Environ Health Perspect. 1998;106(4):213-6.
Alexander, B. H., Checkoway, H., Costa-Mallen, P., Faustman, E. M., Woods, J. S., Kelsey, K. T., van Netten, C., & Costa, L. G. (1998). Interaction of blood lead and delta-aminolevulinic acid dehydratase genotype on markers of heme synthesis and sperm production in lead smelter workers. Environmental Health Perspectives, 106(4), 213-6.
Alexander BH, et al. Interaction of Blood Lead and Delta-aminolevulinic Acid Dehydratase Genotype On Markers of Heme Synthesis and Sperm Production in Lead Smelter Workers. Environ Health Perspect. 1998;106(4):213-6. PubMed PMID: 9495797.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interaction of blood lead and delta-aminolevulinic acid dehydratase genotype on markers of heme synthesis and sperm production in lead smelter workers. AU - Alexander,B H, AU - Checkoway,H, AU - Costa-Mallen,P, AU - Faustman,E M, AU - Woods,J S, AU - Kelsey,K T, AU - van Netten,C, AU - Costa,L G, PY - 1998/3/12/pubmed PY - 1998/3/12/medline PY - 1998/3/12/entrez SP - 213 EP - 6 JF - Environmental health perspectives JO - Environ Health Perspect VL - 106 IS - 4 N2 - The gene that encodes gamma-aminolevulinic acid dehydratase (ALAD) has a polymorphism that may modify lead toxicokinetics and ultimately influence individual susceptibility to lead poisoning. To evaluate the effect of the ALAD polymorphism on lead-mediated outcomes, a cross-sectional study of male employees from a lead-zinc smelter compared associations between blood lead concentration and markers of heme synthesis and semen quality with respect to ALAD genotype. Male employees were recruited via postal questionnaire to donate blood and urine for analysis of blood lead, zinc protoporphyrin (ZPP), urinary coproporphyrin (CPU), and ALAD genotype, and semen samples for semen analysis. Of the 134 workers who had ALAD genotypes completed, 114 (85%) were ALAD1-1 (ALAD1) and 20 (15%) were ALAD1-2 (ALAD2). The mean blood lead concentrations for ALAD1 and ALAD2 were 23.1 and 28.4 microg/dl (p = 0.08), respectively. ZPP/heme ratios were higher in ALAD1 workers (68.6 vs. 57.8 micromol/ml; p = 0.14), and the slope of the blood lead ZPP linear relationship was greater for ALAD1 (2.83 vs. 1.50, p = 0.06). No linear relationship between CPU and blood lead concentration was observed for either ALAD1 or ALAD2. The associations of blood lead concentration with ZPP, CPU, sperm count, and sperm concentration were more evident in workers with the ALAD1 genotype and blood lead concentrations >/= 40 microg/dl. The ALAD genetic polymorphism appears to modify the association between blood lead concentration and ZPP. However, consistent modification of effects were not found for CPU, sperm count, or sperm concentration. SN - 0091-6765 UR - https://www.unboundmedicine.com/medline/citation/9495797/Interaction_of_blood_lead_and_delta_aminolevulinic_acid_dehydratase_genotype_on_markers_of_heme_synthesis_and_sperm_production_in_lead_smelter_workers_ L2 - https://ehp.niehs.nih.gov/doi/10.1289/ehp.98106213?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -