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Thrombosis in congenital deficiencies of AT III, protein C or protein S: a study of 44 children.
Hematol Cell Ther 1997; 39(6):295-9HC

Abstract

Congenital deficiency in coagulation inhibitors is a cause of hereditary thrombotic disease. The severity of symptoms is variable and depends on the type of deficit. In this paper, 44 children suffering from deep venous thrombosis, with a mean age of 5 years, were studied. A search for Lupus anticoagulant (LA) and coagulation inhibitor deficiency showed: 3/44 cases (6.8%) had protein S deficiency, 2/44 cases (4.5%) had protein C deficiency, 1/44 cases (2.3%) had deficiencies in both protein C and S; no cases of AT III deficiency and LA was positive in 2/44 cases (4.5%). Only 1 case of APC resistance out of 13 studied was found. Four family studies were performed and confirmed the congenital origin of the disorder.

Authors+Show Affiliations

Laboratoire d'Hématologie et Banque du Sang, Hôpital d'Enfants de Tunis, Bab Saadoun, Tunisie.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9497888

Citation

Toumi, N H., et al. "Thrombosis in Congenital Deficiencies of at III, Protein C or Protein S: a Study of 44 Children." Hematology and Cell Therapy, vol. 39, no. 6, 1997, pp. 295-9.
Toumi NH, Khaldi F, Ben Becheur S, et al. Thrombosis in congenital deficiencies of AT III, protein C or protein S: a study of 44 children. Hematol Cell Ther. 1997;39(6):295-9.
Toumi, N. H., Khaldi, F., Ben Becheur, S., Hammou, A., Bouttière, B., Sampol, J., & Boukef, K. (1997). Thrombosis in congenital deficiencies of AT III, protein C or protein S: a study of 44 children. Hematology and Cell Therapy, 39(6), pp. 295-9.
Toumi NH, et al. Thrombosis in Congenital Deficiencies of at III, Protein C or Protein S: a Study of 44 Children. Hematol Cell Ther. 1997;39(6):295-9. PubMed PMID: 9497888.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Thrombosis in congenital deficiencies of AT III, protein C or protein S: a study of 44 children. AU - Toumi,N H, AU - Khaldi,F, AU - Ben Becheur,S, AU - Hammou,A, AU - Bouttière,B, AU - Sampol,J, AU - Boukef,K, PY - 1998/3/14/pubmed PY - 1998/3/14/medline PY - 1998/3/14/entrez SP - 295 EP - 9 JF - Hematology and cell therapy JO - Hematol Cell Ther VL - 39 IS - 6 N2 - Congenital deficiency in coagulation inhibitors is a cause of hereditary thrombotic disease. The severity of symptoms is variable and depends on the type of deficit. In this paper, 44 children suffering from deep venous thrombosis, with a mean age of 5 years, were studied. A search for Lupus anticoagulant (LA) and coagulation inhibitor deficiency showed: 3/44 cases (6.8%) had protein S deficiency, 2/44 cases (4.5%) had protein C deficiency, 1/44 cases (2.3%) had deficiencies in both protein C and S; no cases of AT III deficiency and LA was positive in 2/44 cases (4.5%). Only 1 case of APC resistance out of 13 studied was found. Four family studies were performed and confirmed the congenital origin of the disorder. SN - 1269-3286 UR - https://www.unboundmedicine.com/medline/citation/9497888/Thrombosis_in_congenital_deficiencies_of_AT_III_protein_C_or_protein_S:_a_study_of_44_children_ L2 - http://www.diseaseinfosearch.org/result/7087 DB - PRIME DP - Unbound Medicine ER -