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Adipose tissue secretion of plasminogen activator inhibitor-1 in non-obese and obese individuals.
Diabetologia 1998; 41(1):65-71D

Abstract

High plasma plasminogen activator inhibitor-1 (PAI-1) activity is a frequent finding in obesity, and both PAI-1 and obesity are risk factors for cardiovascular disease. To study the mechanisms underlying increased PAI-1 levels in obese individuals, gene expression and secretion of PAI-1 were measured in human abdominal subcutaneous adipose tissue. A total of 32 obese, otherwise healthy subjects and 10 never-obese healthy subjects with a body mass index (BMI) of 42.6 +/- 1.2 and 24.3 +/- 1.9 kg/m2 (mean +/- SEM), respectively, were investigated. Plasma PAI-1 activity, adipose tissue PAI-1 secretion and adipocyte PAI-1 mRNA levels were increased seven-fold (p < 0.0001), sixfold (p < 0.0001) and twofold (p < 0.05), respectively, in the obese group. There were clear associations between adipose tissue secretion of PAI-1 and PAI-1 mRNA levels on the one hand and fat cell volume on the other (r = 0.68, p < 0.0001 and r = 0.51, p < 0.01, respectively, in the obese group). PAI-1 mRNA levels were also related to the amount of PAI-1 secreted among obese individuals (r = 0.31, p = 0.09). It is concluded that adipose tissue secretes significant amounts of PAI-1, that PAI-1 secretion from adipose tissue is increased in obesity, and that PAI-1 secretion is related to the lipid content and cell volume of fat cells. Plasma PAI-1 activity is elevated in obesity, at least in part due to increased gene expression in adipocytes, which, in turn, enhances PAI-1 secretion from adipose tissue.

Authors+Show Affiliations

Atherosclerosis Research Unit, King Gustaf V Research Institute, Karolinska Institute, Stockholm, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9498632

Citation

Eriksson, P, et al. "Adipose Tissue Secretion of Plasminogen Activator Inhibitor-1 in Non-obese and Obese Individuals." Diabetologia, vol. 41, no. 1, 1998, pp. 65-71.
Eriksson P, Reynisdottir S, Lönnqvist F, et al. Adipose tissue secretion of plasminogen activator inhibitor-1 in non-obese and obese individuals. Diabetologia. 1998;41(1):65-71.
Eriksson, P., Reynisdottir, S., Lönnqvist, F., Stemme, V., Hamsten, A., & Arner, P. (1998). Adipose tissue secretion of plasminogen activator inhibitor-1 in non-obese and obese individuals. Diabetologia, 41(1), pp. 65-71.
Eriksson P, et al. Adipose Tissue Secretion of Plasminogen Activator Inhibitor-1 in Non-obese and Obese Individuals. Diabetologia. 1998;41(1):65-71. PubMed PMID: 9498632.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adipose tissue secretion of plasminogen activator inhibitor-1 in non-obese and obese individuals. AU - Eriksson,P, AU - Reynisdottir,S, AU - Lönnqvist,F, AU - Stemme,V, AU - Hamsten,A, AU - Arner,P, PY - 1998/3/14/pubmed PY - 1998/3/14/medline PY - 1998/3/14/entrez SP - 65 EP - 71 JF - Diabetologia JO - Diabetologia VL - 41 IS - 1 N2 - High plasma plasminogen activator inhibitor-1 (PAI-1) activity is a frequent finding in obesity, and both PAI-1 and obesity are risk factors for cardiovascular disease. To study the mechanisms underlying increased PAI-1 levels in obese individuals, gene expression and secretion of PAI-1 were measured in human abdominal subcutaneous adipose tissue. A total of 32 obese, otherwise healthy subjects and 10 never-obese healthy subjects with a body mass index (BMI) of 42.6 +/- 1.2 and 24.3 +/- 1.9 kg/m2 (mean +/- SEM), respectively, were investigated. Plasma PAI-1 activity, adipose tissue PAI-1 secretion and adipocyte PAI-1 mRNA levels were increased seven-fold (p < 0.0001), sixfold (p < 0.0001) and twofold (p < 0.05), respectively, in the obese group. There were clear associations between adipose tissue secretion of PAI-1 and PAI-1 mRNA levels on the one hand and fat cell volume on the other (r = 0.68, p < 0.0001 and r = 0.51, p < 0.01, respectively, in the obese group). PAI-1 mRNA levels were also related to the amount of PAI-1 secreted among obese individuals (r = 0.31, p = 0.09). It is concluded that adipose tissue secretes significant amounts of PAI-1, that PAI-1 secretion from adipose tissue is increased in obesity, and that PAI-1 secretion is related to the lipid content and cell volume of fat cells. Plasma PAI-1 activity is elevated in obesity, at least in part due to increased gene expression in adipocytes, which, in turn, enhances PAI-1 secretion from adipose tissue. SN - 0012-186X UR - https://www.unboundmedicine.com/medline/citation/9498632/Adipose_tissue_secretion_of_plasminogen_activator_inhibitor_1_in_non_obese_and_obese_individuals_ L2 - https://dx.doi.org/10.1007/s001250050868 DB - PRIME DP - Unbound Medicine ER -