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Comparison of allergic aspermatogenesis with that induced by vasectomy. I. In vivo studies in the guinea-pig.
Clin Exp Immunol. 1976 Apr; 24(1):72-80.CE

Abstract

Groups of male and female guinea-pigs were immunized with homologous epdidymal sperm in Freund's complete adjuvant (FCA) and skin tested at weekly intervals with a heat-treated extract of the sperm or with PPD. In females, the skin response to both antigens was similar to that to any standard protein antigen. In males, the response to sperm extract varied with the induced auto-immune orchitis, reaching a maximum immediately after testis lesion was most severe and as recovery was beginning (shown histologically): the response to PPD was decreased at 1 week after immunization, but subsequently was similar to that in females. Skin tests on guinea-pigs 8 months after bilateral vasectomy (when both ends of vasa were ligated), showed no evidence of delayed hypersensitivity to sperm, although there was marked histological evidence of reduced spermatognesis, due to back pressure atrophy.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

949875

Citation

Muir, V Y., et al. "Comparison of Allergic Aspermatogenesis With That Induced By Vasectomy. I. in Vivo Studies in the Guinea-pig." Clinical and Experimental Immunology, vol. 24, no. 1, 1976, pp. 72-80.
Muir VY, Turk JL, Hanley HG. Comparison of allergic aspermatogenesis with that induced by vasectomy. I. In vivo studies in the guinea-pig. Clin Exp Immunol. 1976;24(1):72-80.
Muir, V. Y., Turk, J. L., & Hanley, H. G. (1976). Comparison of allergic aspermatogenesis with that induced by vasectomy. I. In vivo studies in the guinea-pig. Clinical and Experimental Immunology, 24(1), 72-80.
Muir VY, Turk JL, Hanley HG. Comparison of Allergic Aspermatogenesis With That Induced By Vasectomy. I. in Vivo Studies in the Guinea-pig. Clin Exp Immunol. 1976;24(1):72-80. PubMed PMID: 949875.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of allergic aspermatogenesis with that induced by vasectomy. I. In vivo studies in the guinea-pig. AU - Muir,V Y, AU - Turk,J L, AU - Hanley,H G, PY - 1976/4/1/pubmed PY - 1976/4/1/medline PY - 1976/4/1/entrez KW - Animals, Laboratory KW - Antibodies KW - Autoimmune Response KW - Biology KW - Clinical Research KW - Comparative Studies KW - Cytologic Effects KW - Dermatological Effects KW - Family Planning KW - Genitalia KW - Genitalia, Male KW - Histology KW - Immunity KW - Immunologic Factors KW - Male Sterilization KW - Physiology KW - Research Methodology KW - Sterilization, Sexual KW - Studies KW - Testis KW - Urogenital System KW - Vasectomy--side effects SP - 72 EP - 80 JF - Clinical and experimental immunology JO - Clin Exp Immunol VL - 24 IS - 1 N2 - Groups of male and female guinea-pigs were immunized with homologous epdidymal sperm in Freund's complete adjuvant (FCA) and skin tested at weekly intervals with a heat-treated extract of the sperm or with PPD. In females, the skin response to both antigens was similar to that to any standard protein antigen. In males, the response to sperm extract varied with the induced auto-immune orchitis, reaching a maximum immediately after testis lesion was most severe and as recovery was beginning (shown histologically): the response to PPD was decreased at 1 week after immunization, but subsequently was similar to that in females. Skin tests on guinea-pigs 8 months after bilateral vasectomy (when both ends of vasa were ligated), showed no evidence of delayed hypersensitivity to sperm, although there was marked histological evidence of reduced spermatognesis, due to back pressure atrophy. SN - 0009-9104 UR - https://www.unboundmedicine.com/medline/citation/949875/Comparison_of_allergic_aspermatogenesis_with_that_induced_by_vasectomy__I__In_vivo_studies_in_the_guinea_pig_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/949875/ DB - PRIME DP - Unbound Medicine ER -