Tags

Type your tag names separated by a space and hit enter

CD137 (ILA/4-1BB), a member of the TNF receptor family, induces monocyte activation via bidirectional signaling.
J Immunol. 1998 Mar 01; 160(5):2488-94.JI

Abstract

CD137 (ILA/4-1BB), a member of the TNF receptor family, was shown previously to inhibit proliferation and to induce apoptosis in T lymphocytes. In this study, we identify CD137 as a novel and potent monocyte activation factor. CD137 protein induces expression of IL-6, IL-8, and TNF-alpha, and inhibits expression of IL-10. Furthermore, CD137 differentially regulates expression of cell surface receptors. It induces expression of ICAM and reduces expression of FcgammaRIII, while levels of HLA-DR remain unchanged. CD137 also promotes adherence of monocytes. These effects of CD137 require immobilization of CD137 protein, indicating that they are mediated by cross-linking of a corresponding ligand/coreceptor expressed on monocytes.

Authors+Show Affiliations

Department of Pathology, University of Regensburg, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9498794

Citation

Langstein, J, et al. "CD137 (ILA/4-1BB), a Member of the TNF Receptor Family, Induces Monocyte Activation Via Bidirectional Signaling." Journal of Immunology (Baltimore, Md. : 1950), vol. 160, no. 5, 1998, pp. 2488-94.
Langstein J, Michel J, Fritsche J, et al. CD137 (ILA/4-1BB), a member of the TNF receptor family, induces monocyte activation via bidirectional signaling. J Immunol. 1998;160(5):2488-94.
Langstein, J., Michel, J., Fritsche, J., Kreutz, M., Andreesen, R., & Schwarz, H. (1998). CD137 (ILA/4-1BB), a member of the TNF receptor family, induces monocyte activation via bidirectional signaling. Journal of Immunology (Baltimore, Md. : 1950), 160(5), 2488-94.
Langstein J, et al. CD137 (ILA/4-1BB), a Member of the TNF Receptor Family, Induces Monocyte Activation Via Bidirectional Signaling. J Immunol. 1998 Mar 1;160(5):2488-94. PubMed PMID: 9498794.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CD137 (ILA/4-1BB), a member of the TNF receptor family, induces monocyte activation via bidirectional signaling. AU - Langstein,J, AU - Michel,J, AU - Fritsche,J, AU - Kreutz,M, AU - Andreesen,R, AU - Schwarz,H, PY - 1998/3/14/pubmed PY - 1998/3/14/medline PY - 1998/3/14/entrez SP - 2488 EP - 94 JF - Journal of immunology (Baltimore, Md. : 1950) JO - J Immunol VL - 160 IS - 5 N2 - CD137 (ILA/4-1BB), a member of the TNF receptor family, was shown previously to inhibit proliferation and to induce apoptosis in T lymphocytes. In this study, we identify CD137 as a novel and potent monocyte activation factor. CD137 protein induces expression of IL-6, IL-8, and TNF-alpha, and inhibits expression of IL-10. Furthermore, CD137 differentially regulates expression of cell surface receptors. It induces expression of ICAM and reduces expression of FcgammaRIII, while levels of HLA-DR remain unchanged. CD137 also promotes adherence of monocytes. These effects of CD137 require immobilization of CD137 protein, indicating that they are mediated by cross-linking of a corresponding ligand/coreceptor expressed on monocytes. SN - 0022-1767 UR - https://www.unboundmedicine.com/medline/citation/9498794/CD137__ILA/4_1BB__a_member_of_the_TNF_receptor_family_induces_monocyte_activation_via_bidirectional_signaling_ L2 - http://www.jimmunol.org/cgi/pmidlookup?view=long&pmid=9498794 DB - PRIME DP - Unbound Medicine ER -