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The relation of physical activity to risk for symptomatic gallstone disease in men.
Ann Intern Med 1998; 128(6):417-25AIM

Abstract

BACKGROUND

Gallstone disease is a major source of morbidity in the United States. Gallstones are twice as common in women as in men, but severe biliary events leading to surgery occur with equal frequency in the two sexes.

OBJECTIVE

To determine whether physical activity decreases risk for symptomatic gallstone disease in men.

DESIGN

Prospective cohort study.

SETTING

U.S. male health professionals.

PATIENTS

45,813 men 40 to 75 years of age were followed from 1986 to 1994.

MEASUREMENTS

Questionnaires mailed in 1986, 1988, 1990, 1992, and 1994 asked about physical activity, incidence of gallstone disease, age, body weight, dietary and alcohol intake, smoking habits, use of medications, and occurrence of diagnosed medical conditions other than gallstone disease.

RESULTS

828 men reported having newly symptomatic gallstones (diagnosed by ultrasonography or radiography) or undergoing cholecystectomy for recent symptoms. After adjustment for multiple confounders, increased physical activity was inversely related to risk for symptomatic gallstone disease. When extreme quintiles were compared, men younger than 65 years of age had a stronger inverse association (multivariate relative risk, 0.58 [95% CI, 0.44 to 0.78]) with risk than did men 65 years of age or older (relative risk, 0.75 [CI, 0.52 to 1.09]). In contrast, sedentary behavior was positively related to risk for symptomatic gallstone disease. Men who watched television more than 40 hours per week had a higher risk for symptomatic gallstones than men who watched less than 6 hours per week (relative risk for older men, 3.32 [CI, 1.51 to 7.27]; relative risk for younger men, 1.58 [CI, 0.38 to 6.48]).

CONCLUSIONS

Physical activity may play an important role in the prevention of symptomatic gallstone disease in men even beyond its benefit for control of body weight. The results of this study indicate that 34% of cases of symptomatic gallstone disease in men could be prevented by increasing exercise to 30 minutes of endurance-type training five times per week.

Authors+Show Affiliations

Harvard School of Public Health, and Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9499324

Citation

Leitzmann, M F., et al. "The Relation of Physical Activity to Risk for Symptomatic Gallstone Disease in Men." Annals of Internal Medicine, vol. 128, no. 6, 1998, pp. 417-25.
Leitzmann MF, Giovannucci EL, Rimm EB, et al. The relation of physical activity to risk for symptomatic gallstone disease in men. Ann Intern Med. 1998;128(6):417-25.
Leitzmann, M. F., Giovannucci, E. L., Rimm, E. B., Stampfer, M. J., Spiegelman, D., Wing, A. L., & Willett, W. C. (1998). The relation of physical activity to risk for symptomatic gallstone disease in men. Annals of Internal Medicine, 128(6), pp. 417-25.
Leitzmann MF, et al. The Relation of Physical Activity to Risk for Symptomatic Gallstone Disease in Men. Ann Intern Med. 1998 Mar 15;128(6):417-25. PubMed PMID: 9499324.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relation of physical activity to risk for symptomatic gallstone disease in men. AU - Leitzmann,M F, AU - Giovannucci,E L, AU - Rimm,E B, AU - Stampfer,M J, AU - Spiegelman,D, AU - Wing,A L, AU - Willett,W C, PY - 1998/3/14/pubmed PY - 1998/3/14/medline PY - 1998/3/14/entrez SP - 417 EP - 25 JF - Annals of internal medicine JO - Ann. Intern. Med. VL - 128 IS - 6 N2 - BACKGROUND: Gallstone disease is a major source of morbidity in the United States. Gallstones are twice as common in women as in men, but severe biliary events leading to surgery occur with equal frequency in the two sexes. OBJECTIVE: To determine whether physical activity decreases risk for symptomatic gallstone disease in men. DESIGN: Prospective cohort study. SETTING: U.S. male health professionals. PATIENTS: 45,813 men 40 to 75 years of age were followed from 1986 to 1994. MEASUREMENTS: Questionnaires mailed in 1986, 1988, 1990, 1992, and 1994 asked about physical activity, incidence of gallstone disease, age, body weight, dietary and alcohol intake, smoking habits, use of medications, and occurrence of diagnosed medical conditions other than gallstone disease. RESULTS: 828 men reported having newly symptomatic gallstones (diagnosed by ultrasonography or radiography) or undergoing cholecystectomy for recent symptoms. After adjustment for multiple confounders, increased physical activity was inversely related to risk for symptomatic gallstone disease. When extreme quintiles were compared, men younger than 65 years of age had a stronger inverse association (multivariate relative risk, 0.58 [95% CI, 0.44 to 0.78]) with risk than did men 65 years of age or older (relative risk, 0.75 [CI, 0.52 to 1.09]). In contrast, sedentary behavior was positively related to risk for symptomatic gallstone disease. Men who watched television more than 40 hours per week had a higher risk for symptomatic gallstones than men who watched less than 6 hours per week (relative risk for older men, 3.32 [CI, 1.51 to 7.27]; relative risk for younger men, 1.58 [CI, 0.38 to 6.48]). CONCLUSIONS: Physical activity may play an important role in the prevention of symptomatic gallstone disease in men even beyond its benefit for control of body weight. The results of this study indicate that 34% of cases of symptomatic gallstone disease in men could be prevented by increasing exercise to 30 minutes of endurance-type training five times per week. SN - 0003-4819 UR - https://www.unboundmedicine.com/medline/citation/9499324/The_relation_of_physical_activity_to_risk_for_symptomatic_gallstone_disease_in_men_ L2 - https://www.annals.org/article.aspx?volume=128&issue=6&page=417 DB - PRIME DP - Unbound Medicine ER -