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Function of the proximal stomach after Nissen fundoplication.
Br J Surg 1998; 85(2):267-71BJ

Abstract

BACKGROUND

After Nissen fundoplication patients frequently report upper abdominal (dyspeptic) symptoms. Theoretically, these symptoms may be the result of changes in function of the proximal stomach as induced by fundoplication.

METHODS

In this case-control study the response of the proximal stomach to both distension by an air-filled bag and a liquid meal were evaluated with the use of a barostat. In 12 patients after fundoplication and 12 healthy volunteers (age- and sex-matched) perception of symptoms was evaluated during both bag distension and liquid meal stimulus.

RESULTS

The minimal distending pressure required to overcome the intra-abdominal pressure was significantly different between patients and controls (mean(s.e.m.) 9.34(0.26) versus 6.73(0.43) mmHg; P < 0.001). There was no difference between groups in either the fasted state, volume-pressure curve (compliance) or total symptom score. After ingestion of the liquid meal the adaptive relaxation in the fundoplication group was significantly less than that in controls (mean(s.e.m.) 150(29.2) versus 244(34.8) ml; P = 0.04).

CONCLUSION

This study showed that after Nissen fundoplication compliance of the proximal stomach is no different from that in healthy volunteers. Postprandial relaxation of the proximal stomach is decreased and this abnormality may be involved in the pathogenesis of reported dyspeptic symptoms.

Authors+Show Affiliations

Department of Surgery, University Hospital Utrecht, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9501833

Citation

Wijnhoven, B P., et al. "Function of the Proximal Stomach After Nissen Fundoplication." The British Journal of Surgery, vol. 85, no. 2, 1998, pp. 267-71.
Wijnhoven BP, Salet GA, Roelofs JM, et al. Function of the proximal stomach after Nissen fundoplication. Br J Surg. 1998;85(2):267-71.
Wijnhoven, B. P., Salet, G. A., Roelofs, J. M., Smout, A. J., Akkermans, L. M., & Gooszen, H. G. (1998). Function of the proximal stomach after Nissen fundoplication. The British Journal of Surgery, 85(2), pp. 267-71.
Wijnhoven BP, et al. Function of the Proximal Stomach After Nissen Fundoplication. Br J Surg. 1998;85(2):267-71. PubMed PMID: 9501833.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Function of the proximal stomach after Nissen fundoplication. AU - Wijnhoven,B P, AU - Salet,G A, AU - Roelofs,J M, AU - Smout,A J, AU - Akkermans,L M, AU - Gooszen,H G, PY - 1998/3/21/pubmed PY - 1998/3/21/medline PY - 1998/3/21/entrez SP - 267 EP - 71 JF - The British journal of surgery JO - Br J Surg VL - 85 IS - 2 N2 - BACKGROUND: After Nissen fundoplication patients frequently report upper abdominal (dyspeptic) symptoms. Theoretically, these symptoms may be the result of changes in function of the proximal stomach as induced by fundoplication. METHODS: In this case-control study the response of the proximal stomach to both distension by an air-filled bag and a liquid meal were evaluated with the use of a barostat. In 12 patients after fundoplication and 12 healthy volunteers (age- and sex-matched) perception of symptoms was evaluated during both bag distension and liquid meal stimulus. RESULTS: The minimal distending pressure required to overcome the intra-abdominal pressure was significantly different between patients and controls (mean(s.e.m.) 9.34(0.26) versus 6.73(0.43) mmHg; P < 0.001). There was no difference between groups in either the fasted state, volume-pressure curve (compliance) or total symptom score. After ingestion of the liquid meal the adaptive relaxation in the fundoplication group was significantly less than that in controls (mean(s.e.m.) 150(29.2) versus 244(34.8) ml; P = 0.04). CONCLUSION: This study showed that after Nissen fundoplication compliance of the proximal stomach is no different from that in healthy volunteers. Postprandial relaxation of the proximal stomach is decreased and this abnormality may be involved in the pathogenesis of reported dyspeptic symptoms. SN - 0007-1323 UR - https://www.unboundmedicine.com/medline/citation/9501833/Function_of_the_proximal_stomach_after_Nissen_fundoplication_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0007-1323&amp;date=1998&amp;volume=85&amp;issue=2&amp;spage=267 DB - PRIME DP - Unbound Medicine ER -