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Recent observations with beta-adrenoceptor blockade. Beneficial effects in hypertension and heart failure.
Am J Hypertens. 1998 Jan; 11(1 Pt 2):9S-14S.AJ

Abstract

Carvedilol is a third-generation vasodilating beta-blocker initially approved for the treatment of hypertension. It lowers systemic arterial blood pressure without causing reflex tachycardia and preserves renal function. More recently, carvedilol has been shown to reduce morbidity and mortality in patients with congestive heart failure. This reduction may occur in part via beta-blockade and alpha 1-adrenoceptor blockade, the latter resulting in vasodilation. Importantly, carvedilol and several of its metabolites are potent antioxidants that may inhibit the oxidation of norepinephrine and the subsequent formation of toxic intermediates, such as reactive free radicals in the myocardium. As a result, carvedilol inhibits the expression of certain genes involved in myocardial damage, such as intracellular adhesion molecule-1, free-radical-induced activation of transcription factors, and programmed cell death or apoptosis. In this respect, carvedilol represents a new therapy for the treatment of hypertension and congestive heart failure and combines, in one molecule, a number of potentially beneficial properties.

Authors+Show Affiliations

Division of Pharmacological Sciences, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406-0939, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

9503101

Citation

Ruffolo, R R., et al. "Recent Observations With Beta-adrenoceptor Blockade. Beneficial Effects in Hypertension and Heart Failure." American Journal of Hypertension, vol. 11, no. 1 Pt 2, 1998, 9S-14S.
Ruffolo RR, Feuerstein GZ, Ohlstein EH. Recent observations with beta-adrenoceptor blockade. Beneficial effects in hypertension and heart failure. Am J Hypertens. 1998;11(1 Pt 2):9S-14S.
Ruffolo, R. R., Feuerstein, G. Z., & Ohlstein, E. H. (1998). Recent observations with beta-adrenoceptor blockade. Beneficial effects in hypertension and heart failure. American Journal of Hypertension, 11(1 Pt 2), 9S-14S.
Ruffolo RR, Feuerstein GZ, Ohlstein EH. Recent Observations With Beta-adrenoceptor Blockade. Beneficial Effects in Hypertension and Heart Failure. Am J Hypertens. 1998;11(1 Pt 2):9S-14S. PubMed PMID: 9503101.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Recent observations with beta-adrenoceptor blockade. Beneficial effects in hypertension and heart failure. AU - Ruffolo,R R,Jr AU - Feuerstein,G Z, AU - Ohlstein,E H, PY - 1998/3/21/pubmed PY - 2001/3/28/medline PY - 1998/3/21/entrez SP - 9S EP - 14S JF - American journal of hypertension JO - Am J Hypertens VL - 11 IS - 1 Pt 2 N2 - Carvedilol is a third-generation vasodilating beta-blocker initially approved for the treatment of hypertension. It lowers systemic arterial blood pressure without causing reflex tachycardia and preserves renal function. More recently, carvedilol has been shown to reduce morbidity and mortality in patients with congestive heart failure. This reduction may occur in part via beta-blockade and alpha 1-adrenoceptor blockade, the latter resulting in vasodilation. Importantly, carvedilol and several of its metabolites are potent antioxidants that may inhibit the oxidation of norepinephrine and the subsequent formation of toxic intermediates, such as reactive free radicals in the myocardium. As a result, carvedilol inhibits the expression of certain genes involved in myocardial damage, such as intracellular adhesion molecule-1, free-radical-induced activation of transcription factors, and programmed cell death or apoptosis. In this respect, carvedilol represents a new therapy for the treatment of hypertension and congestive heart failure and combines, in one molecule, a number of potentially beneficial properties. SN - 0895-7061 UR - https://www.unboundmedicine.com/medline/citation/9503101/Recent_observations_with_beta_adrenoceptor_blockade__Beneficial_effects_in_hypertension_and_heart_failure_ L2 - https://academic.oup.com/ajh/article-lookup/doi/10.1016/s0895-7061(97)00423-8 DB - PRIME DP - Unbound Medicine ER -