Tags

Type your tag names separated by a space and hit enter

The effect of fenfluramine dosage regimen and reduced food intake on levels of 5-HT in rat brain.
J Neural Transm (Vienna). 1997; 104(11-12):1339-51.JN

Abstract

Male Wistar rats received fenfluramine in subacute (5 mg/kg b.i.d. i.p. for 4 days) or escalating (0.5, 1, 1.5, 2, 3, 4 and 5 mg/kg b.i.d. i.p., each dose given for 4 days) doses. Saline-treated controls received food ad libitum, or were pair-fed with the fenfluramine-treated animals. Rats were killed 1, 15 and 30 days after drug withdrawal. On day 1, plasma and brain fenfluramine levels were higher, and hypothalamus norfenfluramine levels were lower following escalating compared to subacute dosing, although total active drug levels were unaltered. Both treatment regimes, and pair-feeding reduced food intake and body weight. Subacute fenfluramine reduced brain 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) levels for up to 30 days. Brain 5-HT and 5-HIAA levels were unaltered following escalating-doses of fenfluramine. Additionally, pair-feeding transiently decreased hippocampal 5-HT levels. These data suggest that escalating-doses of fenfluramine prevent the 5-HT-depleting effect of a sub-cute challenge without altering the anorexic action of the drug.

Authors+Show Affiliations

Neurodegenerative Diseases Research Centre, King's College, London, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9503280

Citation

Rose, S, et al. "The Effect of Fenfluramine Dosage Regimen and Reduced Food Intake On Levels of 5-HT in Rat Brain." Journal of Neural Transmission (Vienna, Austria : 1996), vol. 104, no. 11-12, 1997, pp. 1339-51.
Rose S, Hindmarsh JG, Collins P, et al. The effect of fenfluramine dosage regimen and reduced food intake on levels of 5-HT in rat brain. J Neural Transm (Vienna). 1997;104(11-12):1339-51.
Rose, S., Hindmarsh, J. G., Collins, P., & Jenner, P. (1997). The effect of fenfluramine dosage regimen and reduced food intake on levels of 5-HT in rat brain. Journal of Neural Transmission (Vienna, Austria : 1996), 104(11-12), 1339-51.
Rose S, et al. The Effect of Fenfluramine Dosage Regimen and Reduced Food Intake On Levels of 5-HT in Rat Brain. J Neural Transm (Vienna). 1997;104(11-12):1339-51. PubMed PMID: 9503280.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of fenfluramine dosage regimen and reduced food intake on levels of 5-HT in rat brain. AU - Rose,S, AU - Hindmarsh,J G, AU - Collins,P, AU - Jenner,P, PY - 1997/1/1/pubmed PY - 1998/3/21/medline PY - 1997/1/1/entrez SP - 1339 EP - 51 JF - Journal of neural transmission (Vienna, Austria : 1996) JO - J Neural Transm (Vienna) VL - 104 IS - 11-12 N2 - Male Wistar rats received fenfluramine in subacute (5 mg/kg b.i.d. i.p. for 4 days) or escalating (0.5, 1, 1.5, 2, 3, 4 and 5 mg/kg b.i.d. i.p., each dose given for 4 days) doses. Saline-treated controls received food ad libitum, or were pair-fed with the fenfluramine-treated animals. Rats were killed 1, 15 and 30 days after drug withdrawal. On day 1, plasma and brain fenfluramine levels were higher, and hypothalamus norfenfluramine levels were lower following escalating compared to subacute dosing, although total active drug levels were unaltered. Both treatment regimes, and pair-feeding reduced food intake and body weight. Subacute fenfluramine reduced brain 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) levels for up to 30 days. Brain 5-HT and 5-HIAA levels were unaltered following escalating-doses of fenfluramine. Additionally, pair-feeding transiently decreased hippocampal 5-HT levels. These data suggest that escalating-doses of fenfluramine prevent the 5-HT-depleting effect of a sub-cute challenge without altering the anorexic action of the drug. SN - 0300-9564 UR - https://www.unboundmedicine.com/medline/citation/9503280/The_effect_of_fenfluramine_dosage_regimen_and_reduced_food_intake_on_levels_of_5_HT_in_rat_brain_ L2 - https://doi.org/10.1007/BF01294735 DB - PRIME DP - Unbound Medicine ER -