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Effects of nitric oxide synthase inhibition on phospholipid fatty acid composition of brown adipose tissue.
Jpn J Physiol 1997; 47(5):477-80JJ

Abstract

We investigated the effects of nitric oxide synthase inhibition on the phospholipid fatty acid composition of brown adipose tissue by administering chronic N omega-nitro-L-arginine methyl ester (L-NAME) (0.01%) to rats via drinking water. L-NAME caused a significant decrease in C14:0, C16:0, C16:1 and C18:1, with a concomitant increase in C18:0 and C18:2, L-NAME treatment elicited an increase in the unsaturation index. There were no significant changes in other fatty acids including the polyunsaturated fatty acids docosahexaenoate (DHA, C22:6) and arachidonate (C20:4). Polyunsaturated fatty acid linoleate (C18:2) was increased and the arachidonate index decreased in the L-NAME-treated group, suggesting a diminished conversion of C18:2 to C20:4.

Authors+Show Affiliations

Department of Physiology I, Asahikawa Medical College, Japan. saha@asahikawa-med.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9504135

Citation

Saha, S K., et al. "Effects of Nitric Oxide Synthase Inhibition On Phospholipid Fatty Acid Composition of Brown Adipose Tissue." The Japanese Journal of Physiology, vol. 47, no. 5, 1997, pp. 477-80.
Saha SK, Ohno T, Ohinata H, et al. Effects of nitric oxide synthase inhibition on phospholipid fatty acid composition of brown adipose tissue. Jpn J Physiol. 1997;47(5):477-80.
Saha, S. K., Ohno, T., Ohinata, H., & Kuroshima, A. (1997). Effects of nitric oxide synthase inhibition on phospholipid fatty acid composition of brown adipose tissue. The Japanese Journal of Physiology, 47(5), pp. 477-80.
Saha SK, et al. Effects of Nitric Oxide Synthase Inhibition On Phospholipid Fatty Acid Composition of Brown Adipose Tissue. Jpn J Physiol. 1997;47(5):477-80. PubMed PMID: 9504135.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of nitric oxide synthase inhibition on phospholipid fatty acid composition of brown adipose tissue. AU - Saha,S K, AU - Ohno,T, AU - Ohinata,H, AU - Kuroshima,A, PY - 1998/3/21/pubmed PY - 1998/3/21/medline PY - 1998/3/21/entrez SP - 477 EP - 80 JF - The Japanese journal of physiology JO - Jpn. J. Physiol. VL - 47 IS - 5 N2 - We investigated the effects of nitric oxide synthase inhibition on the phospholipid fatty acid composition of brown adipose tissue by administering chronic N omega-nitro-L-arginine methyl ester (L-NAME) (0.01%) to rats via drinking water. L-NAME caused a significant decrease in C14:0, C16:0, C16:1 and C18:1, with a concomitant increase in C18:0 and C18:2, L-NAME treatment elicited an increase in the unsaturation index. There were no significant changes in other fatty acids including the polyunsaturated fatty acids docosahexaenoate (DHA, C22:6) and arachidonate (C20:4). Polyunsaturated fatty acid linoleate (C18:2) was increased and the arachidonate index decreased in the L-NAME-treated group, suggesting a diminished conversion of C18:2 to C20:4. SN - 0021-521X UR - https://www.unboundmedicine.com/medline/citation/9504135/Effects_of_nitric_oxide_synthase_inhibition_on_phospholipid_fatty_acid_composition_of_brown_adipose_tissue_ L2 - http://joi.jlc.jst.go.jp/JST.JSTAGE/jjphysiol/47.477?from=PubMed DB - PRIME DP - Unbound Medicine ER -