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Analysis of the EEG bispectrum, auditory evoked potentials and the EEG power spectrum during repeated transitions from consciousness to unconsciousness.
Br J Anaesth. 1998 Jan; 80(1):46-52.BJ

Abstract

We have compared the auditory evoked potential (AEP) index (a numerical index derived from the AEP), 95% spectral edge frequency (SEF), median frequency (MF) and the bispectral index (BIS) during alternating periods of consciousness and unconsciousness produced by target-controlled infusions of propofol. We studied 12 patients undergoing hip or knee replacement under spinal anaesthesia. During periods of consciousness and unconsciousness, respective mean values for the four measurements were: AEP index, 60.8 (SD 13.7) and 37.6 (6.5); BIS, 85.1 (8.2) and 66.8 (10.5); SEF, 24.2 (2.2) and 18.7 (2.1); and MF, 10.9 (3.3) and 8.8 (2.0). Threshold values with a specificity of 100% for a state of unconsciousness were: AEP index, 37 (sensitivity 52%); BIS, 55 (sensitivity 15%); and SEF, 16.0 (sensitivity 9%). There was no recorded value for MF that was 100% specific for unconsciousness. Of the four measurements, only AEP index demonstrated a significant difference (P < 0.05) between all mean values 1 min before recovery of consciousness and all mean values 1 min after recovery of consciousness. Our findings suggest that of the four electrophysiological variables, AEP index was best at distinguishing the transition from unconsciousness to consciousness.

Authors+Show Affiliations

University Department of Anaesthesia, HCI International Medical Centre, Clydebank, Scotland.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

9505777

Citation

Gajraj, R J., et al. "Analysis of the EEG Bispectrum, Auditory Evoked Potentials and the EEG Power Spectrum During Repeated Transitions From Consciousness to Unconsciousness." British Journal of Anaesthesia, vol. 80, no. 1, 1998, pp. 46-52.
Gajraj RJ, Doi M, Mantzaridis H, et al. Analysis of the EEG bispectrum, auditory evoked potentials and the EEG power spectrum during repeated transitions from consciousness to unconsciousness. Br J Anaesth. 1998;80(1):46-52.
Gajraj, R. J., Doi, M., Mantzaridis, H., & Kenny, G. N. (1998). Analysis of the EEG bispectrum, auditory evoked potentials and the EEG power spectrum during repeated transitions from consciousness to unconsciousness. British Journal of Anaesthesia, 80(1), 46-52.
Gajraj RJ, et al. Analysis of the EEG Bispectrum, Auditory Evoked Potentials and the EEG Power Spectrum During Repeated Transitions From Consciousness to Unconsciousness. Br J Anaesth. 1998;80(1):46-52. PubMed PMID: 9505777.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analysis of the EEG bispectrum, auditory evoked potentials and the EEG power spectrum during repeated transitions from consciousness to unconsciousness. AU - Gajraj,R J, AU - Doi,M, AU - Mantzaridis,H, AU - Kenny,G N, PY - 1998/3/20/pubmed PY - 1998/3/20/medline PY - 1998/3/20/entrez SP - 46 EP - 52 JF - British journal of anaesthesia JO - Br J Anaesth VL - 80 IS - 1 N2 - We have compared the auditory evoked potential (AEP) index (a numerical index derived from the AEP), 95% spectral edge frequency (SEF), median frequency (MF) and the bispectral index (BIS) during alternating periods of consciousness and unconsciousness produced by target-controlled infusions of propofol. We studied 12 patients undergoing hip or knee replacement under spinal anaesthesia. During periods of consciousness and unconsciousness, respective mean values for the four measurements were: AEP index, 60.8 (SD 13.7) and 37.6 (6.5); BIS, 85.1 (8.2) and 66.8 (10.5); SEF, 24.2 (2.2) and 18.7 (2.1); and MF, 10.9 (3.3) and 8.8 (2.0). Threshold values with a specificity of 100% for a state of unconsciousness were: AEP index, 37 (sensitivity 52%); BIS, 55 (sensitivity 15%); and SEF, 16.0 (sensitivity 9%). There was no recorded value for MF that was 100% specific for unconsciousness. Of the four measurements, only AEP index demonstrated a significant difference (P < 0.05) between all mean values 1 min before recovery of consciousness and all mean values 1 min after recovery of consciousness. Our findings suggest that of the four electrophysiological variables, AEP index was best at distinguishing the transition from unconsciousness to consciousness. SN - 0007-0912 UR - https://www.unboundmedicine.com/medline/citation/9505777/Analysis_of_the_EEG_bispectrum_auditory_evoked_potentials_and_the_EEG_power_spectrum_during_repeated_transitions_from_consciousness_to_unconsciousness_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0007-0912(17)40579-4 DB - PRIME DP - Unbound Medicine ER -