Dissolution rate of furosemide from polyethylene glycol solid dispersions.Farmaco. 1997 Oct; 52(10):625-9.F
In this study, by preparing the solid dispersions of furosemide, a substance that is poor-soluble in water, with polyethylene glycol 6000, 10,000 and 20,000, the enhancement of the dissolution rate of furosemide has been aimed. Solid dispersions were prepared by the fusion method in proportions of 1:4, 1:6 and 1:10 (active material/polymer). The formation of solid dispersion was tested by the techniques of X-ray diffraction, differential calorimetry (DSC) and infrared spectroscopy (IR). The release rate of active material from the solid dispersions prepared was examined by using the flow through cell method. Also, the effect of particle size of the complexes obtained, on the dissolution rate and the stabilities of these complexes were studied. It was determined that the dissolution rate of furosemide was markedly increased along with the formation of the complex and that a better dissolution profile was obtained even in the physical mixtures prepared for the purposes of comparison. It was found that the molecular weights of different kinds of polyethylene glycols and the various proportions of active material/polymer complexes as well as the particle sizes of the solid dispersions were not efficient in the release rate of active material. It was concluded that the increase of the dissolution rate was being a result of both wettability and solubility enhancing effects of polyethylene glycols.