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Dissolution rate of furosemide from polyethylene glycol solid dispersions.
Farmaco. 1997 Oct; 52(10):625-9.F

Abstract

In this study, by preparing the solid dispersions of furosemide, a substance that is poor-soluble in water, with polyethylene glycol 6000, 10,000 and 20,000, the enhancement of the dissolution rate of furosemide has been aimed. Solid dispersions were prepared by the fusion method in proportions of 1:4, 1:6 and 1:10 (active material/polymer). The formation of solid dispersion was tested by the techniques of X-ray diffraction, differential calorimetry (DSC) and infrared spectroscopy (IR). The release rate of active material from the solid dispersions prepared was examined by using the flow through cell method. Also, the effect of particle size of the complexes obtained, on the dissolution rate and the stabilities of these complexes were studied. It was determined that the dissolution rate of furosemide was markedly increased along with the formation of the complex and that a better dissolution profile was obtained even in the physical mixtures prepared for the purposes of comparison. It was found that the molecular weights of different kinds of polyethylene glycols and the various proportions of active material/polymer complexes as well as the particle sizes of the solid dispersions were not efficient in the release rate of active material. It was concluded that the increase of the dissolution rate was being a result of both wettability and solubility enhancing effects of polyethylene glycols.

Authors+Show Affiliations

Ozdemir N
Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Ankara, Tandoğan, Türkiye.
Ordu S
No affiliation info available

MeSH

Calorimetry, Differential ScanningDosage FormsDrug StabilityFurosemidePolyethylene GlycolsSolubilitySolventsSpectrophotometry, InfraredX-Ray Diffraction

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9507675

Citation

Ozdemir, N, and S Ordu. "Dissolution Rate of Furosemide From Polyethylene Glycol Solid Dispersions." Farmaco (Societa Chimica Italiana : 1989), vol. 52, no. 10, 1997, pp. 625-9.
Ozdemir N, Ordu S. Dissolution rate of furosemide from polyethylene glycol solid dispersions. Farmaco. 1997;52(10):625-9.
Ozdemir, N., & Ordu, S. (1997). Dissolution rate of furosemide from polyethylene glycol solid dispersions. Farmaco (Societa Chimica Italiana : 1989), 52(10), 625-9.
Ozdemir N, Ordu S. Dissolution Rate of Furosemide From Polyethylene Glycol Solid Dispersions. Farmaco. 1997;52(10):625-9. PubMed PMID: 9507675.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dissolution rate of furosemide from polyethylene glycol solid dispersions. AU - Ozdemir,N, AU - Ordu,S, PY - 1998/3/21/pubmed PY - 1998/3/21/medline PY - 1998/3/21/entrez SP - 625 EP - 9 JF - Farmaco (Societa chimica italiana : 1989) JO - Farmaco VL - 52 IS - 10 N2 - In this study, by preparing the solid dispersions of furosemide, a substance that is poor-soluble in water, with polyethylene glycol 6000, 10,000 and 20,000, the enhancement of the dissolution rate of furosemide has been aimed. Solid dispersions were prepared by the fusion method in proportions of 1:4, 1:6 and 1:10 (active material/polymer). The formation of solid dispersion was tested by the techniques of X-ray diffraction, differential calorimetry (DSC) and infrared spectroscopy (IR). The release rate of active material from the solid dispersions prepared was examined by using the flow through cell method. Also, the effect of particle size of the complexes obtained, on the dissolution rate and the stabilities of these complexes were studied. It was determined that the dissolution rate of furosemide was markedly increased along with the formation of the complex and that a better dissolution profile was obtained even in the physical mixtures prepared for the purposes of comparison. It was found that the molecular weights of different kinds of polyethylene glycols and the various proportions of active material/polymer complexes as well as the particle sizes of the solid dispersions were not efficient in the release rate of active material. It was concluded that the increase of the dissolution rate was being a result of both wettability and solubility enhancing effects of polyethylene glycols. SN - 0014-827X UR - https://www.unboundmedicine.com/medline/citation/9507675/Dissolution_rate_of_furosemide_from_polyethylene_glycol_solid_dispersions_ DB - PRIME DP - Unbound Medicine ER -