Tags

Type your tag names separated by a space and hit enter

Glycaemic control and development of retinopathy in type 2 diabetes mellitus: a longitudinal study.
Diabet Med 1998; 15(2):151-5DM

Abstract

Relationships between glycaemic control, hypertension, and development of microangiopathy have been well documented in Type 1 (insulin-dependent) but not in Type 2 (non-insulin-dependent) diabetes mellitus. Therefore, we have investigated these relationships in a cohort of 64 Type 2 patients free of retinopathy (by angiofluorography), who were regularly followed until development of retinopathy or for at least 7 years as outpatients. Glycaemic control was assessed by 1 to 4 HbA1 determinations per year. Retinal status was monitored by annual angiofluorography. Nonproliferative retinopathy developed in 14 patients (cumulative incidence at 13 years: 29.8%) after a mean diabetes duration of 14.3+/-8.9 years (range 2-27). In multivariate analysis (Cox model), mean HbA1 during follow-up (p < 0.001), and hypertension at first examination (p = 0.09) were associated with the development of retinopathy, but age, sex, BMI, diabetes duration, smoking, and fasting blood glucose were not. The relative risk for developing retinopathy (RR) was 7.2 (IC 95%: 1.61-32.4) in patients with a mean HbA1 during follow-up above the median value of the cohort (8.3%) compared with patients with HbA1 during follow-up below this value. RR was 2.5 (IC 0.8-8) in patients with HbA1 at first examination above compared to below the median value (8.4%). RR was 3.0 (IC 0.9-10) in patients treated for hypertension at baseline compared to those without treatment. A sixfold increase in retinopathy prevalence was observed between patients with mean HbA1 in the highest or lowest quartile of mean HbA1 distribution during follow-up. This longitudinal study indicates a strong association between long-term glycaemic control and the development of diabetic retinopathy in Type 2 diabetes.

Authors+Show Affiliations

Service de Médecine B, Hôpital Lariboisière, Faculté de Médecine Lariboisière-Saint Louis Université Paris 7 Denis Diderot, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9507917

Citation

Guillausseau, P J., et al. "Glycaemic Control and Development of Retinopathy in Type 2 Diabetes Mellitus: a Longitudinal Study." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 15, no. 2, 1998, pp. 151-5.
Guillausseau PJ, Massin P, Charles MA, et al. Glycaemic control and development of retinopathy in type 2 diabetes mellitus: a longitudinal study. Diabet Med. 1998;15(2):151-5.
Guillausseau, P. J., Massin, P., Charles, M. A., Allaguy, H., Güvenli, Z., Virally, M., ... Lubetzki, J. (1998). Glycaemic control and development of retinopathy in type 2 diabetes mellitus: a longitudinal study. Diabetic Medicine : a Journal of the British Diabetic Association, 15(2), pp. 151-5.
Guillausseau PJ, et al. Glycaemic Control and Development of Retinopathy in Type 2 Diabetes Mellitus: a Longitudinal Study. Diabet Med. 1998;15(2):151-5. PubMed PMID: 9507917.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glycaemic control and development of retinopathy in type 2 diabetes mellitus: a longitudinal study. AU - Guillausseau,P J, AU - Massin,P, AU - Charles,M A, AU - Allaguy,H, AU - Güvenli,Z, AU - Virally,M, AU - Tielmans,D, AU - Assayag,M, AU - Warnet,A, AU - Lubetzki,J, PY - 1998/3/21/pubmed PY - 1998/3/21/medline PY - 1998/3/21/entrez SP - 151 EP - 5 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet. Med. VL - 15 IS - 2 N2 - Relationships between glycaemic control, hypertension, and development of microangiopathy have been well documented in Type 1 (insulin-dependent) but not in Type 2 (non-insulin-dependent) diabetes mellitus. Therefore, we have investigated these relationships in a cohort of 64 Type 2 patients free of retinopathy (by angiofluorography), who were regularly followed until development of retinopathy or for at least 7 years as outpatients. Glycaemic control was assessed by 1 to 4 HbA1 determinations per year. Retinal status was monitored by annual angiofluorography. Nonproliferative retinopathy developed in 14 patients (cumulative incidence at 13 years: 29.8%) after a mean diabetes duration of 14.3+/-8.9 years (range 2-27). In multivariate analysis (Cox model), mean HbA1 during follow-up (p < 0.001), and hypertension at first examination (p = 0.09) were associated with the development of retinopathy, but age, sex, BMI, diabetes duration, smoking, and fasting blood glucose were not. The relative risk for developing retinopathy (RR) was 7.2 (IC 95%: 1.61-32.4) in patients with a mean HbA1 during follow-up above the median value of the cohort (8.3%) compared with patients with HbA1 during follow-up below this value. RR was 2.5 (IC 0.8-8) in patients with HbA1 at first examination above compared to below the median value (8.4%). RR was 3.0 (IC 0.9-10) in patients treated for hypertension at baseline compared to those without treatment. A sixfold increase in retinopathy prevalence was observed between patients with mean HbA1 in the highest or lowest quartile of mean HbA1 distribution during follow-up. This longitudinal study indicates a strong association between long-term glycaemic control and the development of diabetic retinopathy in Type 2 diabetes. SN - 0742-3071 UR - https://www.unboundmedicine.com/medline/citation/9507917/Glycaemic_control_and_development_of_retinopathy_in_type_2_diabetes_mellitus:_a_longitudinal_study_ L2 - http://www.diseaseinfosearch.org/result/8215 DB - PRIME DP - Unbound Medicine ER -