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Substituting milk for apple juice does not increase kidney stone risk in most normocalciuric adults who form calcium oxalate stones.

Abstract

OBJECTIVE

Increasing intake of dietary calcium from less than 400 mg to 800 mg daily may decrease the absorption of dietary oxalate, which in turn would decrease urinary oxalate excretion. The effect of substituting milk for apple juice on urine composition and risk of calcium oxalate precipitability was studied.

SUBJECTS

Twenty-one normocalciuric adults with a history of at least 1 calcium oxalate stone and urinary oxalate excretion exceeding 275 micromol/day on their self-selected diet.

DESIGN

Randomized crossover trial.

INTERVENTION

Each participant consumed two moderate-oxalate (2,011 micromol/day) study diets, which were identical except that one contained 360 mL milk and the other contained 540 mL apple juice as the beverage with meals.

SETTING

Four days free-living then 2 days in the metabolic unit of a university nutrition department.

MAIN OUTCOME MEASURE

Tiselius risk index for calcium oxalate precipitability calculated from urine composition.

STATISTICAL ANALYSES

Paired t tests.

RESULTS

Twenty-four hour urinary oxalate excretion was 18% lower (P<.0001) on the milk diet vs the juice diet: 423 vs 514 micromol, respectively. Calcium excretion was 17% higher (P<.05) on the milk vs juice diet: 4.7 vs 3.9 mmol, respectively. Urinary magnesium and citrate excretion, volume, and Tiselius risk index did not differ between diets.

APPLICATIONS

Substituting 360 mL milk daily for apple juice with meals in a diet containing moderate amounts of dietary oxalate from whole grains, legumes, fruits, and vegetables does not increase the risk index of calcium oxalate precipitability in most normocalciuric adults who form stones.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Food Science and Human Nutrition, Washington State University, Spokane 99201-3899, USA.

    Source

    MeSH

    Adult
    Aged
    Animals
    Beverages
    Calcium
    Calcium Oxalate
    Calcium, Dietary
    Cross-Over Studies
    Female
    Humans
    Kidney Calculi
    Male
    Middle Aged
    Milk
    Oxalates
    Risk Factors
    Rosales

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    9508013

    Citation

    Massey, L K., and S A. Kynast-Gales. "Substituting Milk for Apple Juice Does Not Increase Kidney Stone Risk in Most Normocalciuric Adults Who Form Calcium Oxalate Stones." Journal of the American Dietetic Association, vol. 98, no. 3, 1998, pp. 303-8.
    Massey LK, Kynast-Gales SA. Substituting milk for apple juice does not increase kidney stone risk in most normocalciuric adults who form calcium oxalate stones. J Am Diet Assoc. 1998;98(3):303-8.
    Massey, L. K., & Kynast-Gales, S. A. (1998). Substituting milk for apple juice does not increase kidney stone risk in most normocalciuric adults who form calcium oxalate stones. Journal of the American Dietetic Association, 98(3), pp. 303-8.
    Massey LK, Kynast-Gales SA. Substituting Milk for Apple Juice Does Not Increase Kidney Stone Risk in Most Normocalciuric Adults Who Form Calcium Oxalate Stones. J Am Diet Assoc. 1998;98(3):303-8. PubMed PMID: 9508013.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Substituting milk for apple juice does not increase kidney stone risk in most normocalciuric adults who form calcium oxalate stones. AU - Massey,L K, AU - Kynast-Gales,S A, PY - 1998/3/21/pubmed PY - 1998/3/21/medline PY - 1998/3/21/entrez SP - 303 EP - 8 JF - Journal of the American Dietetic Association JO - J Am Diet Assoc VL - 98 IS - 3 N2 - OBJECTIVE: Increasing intake of dietary calcium from less than 400 mg to 800 mg daily may decrease the absorption of dietary oxalate, which in turn would decrease urinary oxalate excretion. The effect of substituting milk for apple juice on urine composition and risk of calcium oxalate precipitability was studied. SUBJECTS: Twenty-one normocalciuric adults with a history of at least 1 calcium oxalate stone and urinary oxalate excretion exceeding 275 micromol/day on their self-selected diet. DESIGN: Randomized crossover trial. INTERVENTION: Each participant consumed two moderate-oxalate (2,011 micromol/day) study diets, which were identical except that one contained 360 mL milk and the other contained 540 mL apple juice as the beverage with meals. SETTING: Four days free-living then 2 days in the metabolic unit of a university nutrition department. MAIN OUTCOME MEASURE: Tiselius risk index for calcium oxalate precipitability calculated from urine composition. STATISTICAL ANALYSES: Paired t tests. RESULTS: Twenty-four hour urinary oxalate excretion was 18% lower (P<.0001) on the milk diet vs the juice diet: 423 vs 514 micromol, respectively. Calcium excretion was 17% higher (P<.05) on the milk vs juice diet: 4.7 vs 3.9 mmol, respectively. Urinary magnesium and citrate excretion, volume, and Tiselius risk index did not differ between diets. APPLICATIONS: Substituting 360 mL milk daily for apple juice with meals in a diet containing moderate amounts of dietary oxalate from whole grains, legumes, fruits, and vegetables does not increase the risk index of calcium oxalate precipitability in most normocalciuric adults who form stones. SN - 0002-8223 UR - https://www.unboundmedicine.com/medline/citation/9508013/Substituting_milk_for_apple_juice_does_not_increase_kidney_stone_risk_in_most_normocalciuric_adults_who_form_calcium_oxalate_stones_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-8223(98)00071-6 DB - PRIME DP - Unbound Medicine ER -