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RETRACTED ARTICLE

Prevention of nausea and vomiting in female patients undergoing breast surgery: a comparison with granisetron, droperidol, metoclopramide and placebo.
Acta Anaesthesiol Scand. 1998 Feb; 42(2):220-4.AA

Abstract

BACKGROUND

Breast surgery is associated with a relatively high incidence of postoperative nausea and vomiting (PONV). This study was undertaken to evaluate the efficacy of granisetron, droperidol and metoclopramide for preventing PONV after breast surgery.

METHODS

In a randomized, double-blind, placebo-controlled trial, 120 female patients received granisetron 40 micrograms.kg-1, droperidol 1.25 mg, metoclopramide 10 mg or placebo (saline) (n = 30 for each) intravenously immediately before the induction of anaesthesia. A standard general anaesthetic technique was employed throughout. Postoperatively, during the first 24 h after anaesthesia, the incidence of PONV and adverse events was recorded.

RESULTS

The incidence of PONV was 17% with granisetron, 37% with droperidol, 43% with metoclopramide and 50% with placebo (P < 0.05; overall Fisher's exact probability test). The incidence of adverse events was not different among the groups.

CONCLUSION

Granisetron is highly effective for reducing the incidence of PONV in female patients undergoing breast surgery. Droperidol and metoclopramide are ineffective in this population.

Authors+Show Affiliations

Department of Anaesthesiology, Toride Kyodo General Hospital, Ibaraki, Japan.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Retracted Publication

Language

eng

PubMed ID

9509207

Citation

Fujii, Y, et al. "Prevention of Nausea and Vomiting in Female Patients Undergoing Breast Surgery: a Comparison With Granisetron, Droperidol, Metoclopramide and Placebo." Acta Anaesthesiologica Scandinavica, vol. 42, no. 2, 1998, pp. 220-4.
Fujii Y, Tanaka H, Toyooka H. Prevention of nausea and vomiting in female patients undergoing breast surgery: a comparison with granisetron, droperidol, metoclopramide and placebo. Acta Anaesthesiol Scand. 1998;42(2):220-4.
Fujii, Y., Tanaka, H., & Toyooka, H. (1998). Prevention of nausea and vomiting in female patients undergoing breast surgery: a comparison with granisetron, droperidol, metoclopramide and placebo. Acta Anaesthesiologica Scandinavica, 42(2), 220-4.
Fujii Y, Tanaka H, Toyooka H. Prevention of Nausea and Vomiting in Female Patients Undergoing Breast Surgery: a Comparison With Granisetron, Droperidol, Metoclopramide and Placebo. Acta Anaesthesiol Scand. 1998;42(2):220-4. PubMed PMID: 9509207.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevention of nausea and vomiting in female patients undergoing breast surgery: a comparison with granisetron, droperidol, metoclopramide and placebo. AU - Fujii,Y, AU - Tanaka,H, AU - Toyooka,H, PY - 1998/3/24/pubmed PY - 1998/3/24/medline PY - 1998/3/24/entrez SP - 220 EP - 4 JF - Acta anaesthesiologica Scandinavica JO - Acta Anaesthesiol Scand VL - 42 IS - 2 N2 - BACKGROUND: Breast surgery is associated with a relatively high incidence of postoperative nausea and vomiting (PONV). This study was undertaken to evaluate the efficacy of granisetron, droperidol and metoclopramide for preventing PONV after breast surgery. METHODS: In a randomized, double-blind, placebo-controlled trial, 120 female patients received granisetron 40 micrograms.kg-1, droperidol 1.25 mg, metoclopramide 10 mg or placebo (saline) (n = 30 for each) intravenously immediately before the induction of anaesthesia. A standard general anaesthetic technique was employed throughout. Postoperatively, during the first 24 h after anaesthesia, the incidence of PONV and adverse events was recorded. RESULTS: The incidence of PONV was 17% with granisetron, 37% with droperidol, 43% with metoclopramide and 50% with placebo (P < 0.05; overall Fisher's exact probability test). The incidence of adverse events was not different among the groups. CONCLUSION: Granisetron is highly effective for reducing the incidence of PONV in female patients undergoing breast surgery. Droperidol and metoclopramide are ineffective in this population. SN - 0001-5172 UR - https://www.unboundmedicine.com/medline/citation/9509207/Prevention_of_nausea_and_vomiting_in_female_patients_undergoing_breast_surgery:_a_comparison_with_granisetron_droperidol_metoclopramide_and_placebo_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0001-5172&amp;date=1998&amp;volume=42&amp;issue=2&amp;spage=220 DB - PRIME DP - Unbound Medicine ER -